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| 1 | Combined laparoscopic spleen-preserving distal pancreatectomy and islet autotransplantation for benign pancreatic neoplasm显示文摘AIM:To evaluate the safety and feasibility of laparoscopic spleen-preserving distal pancreatectomy(LSPDP)with autologous islet transplantation(AIT)for benign tumors of the pancreatic body-neck.METHODS:Three non-diabetic,female patients(age37,44 and 35 years,respectively)were declared candidates for surgery,between May and September 2011,because of pancreatic body/neck cystic lesions.The planned operation was an LSPDP associated with AIT from the normal pancreas distal to the neoplasm.Islets isolation was performed on the residual pancreatic parenchyma after frozen section examination of the margin.Purified autologous islets were infused into the portal vein by a percutaneous transhepatic approach the day after surgery.RESULTS:The procedure was performed successfully in all the three cases,and the spleen was preserved along with its vessels.Mean operation time was 283±52 min and average blood loss was 133±57 mL.Residual pancreas weights were 33,22 and 30 g,and105.200,40.390 and 94.790 islet equivalents were isolated,respectively.Surgical complications occurred in one patient(grade A pancreatic fistula).Postoperative stays were 6,6 and 7 d,respectively.Histopathological evaluation revealed mucinous cystic neoplasm in cases1 and 3,and serous cystic neoplasm in patient 2.No postoperative insulin administration was required.One patient developed a transient partial portal thrombosis2 mo after islet infusion.Patients are insulin independent at a mean follow up of 8±2 mo.CONCLUSION:Combination of LSPDP and AIT is feasible and could be effective to minimize the surgical impact for benign neoplasm of pancreatic body-neck. | Gianpaolo Balzano Michele Carvello Lorenzo Piemonti Rita Nano Riccardo Ariotti Alessia Mercalli Raffaella Melzi Paola Maffi Marco Braga Carlo Staudacher | 2014 | World Journal of Gastroenterology2014，20，14： | 4 |
| 2 | Fasting plasma leptin, tumor necrosis {actor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women:impact on cardiovascular mortality显示文摘 | Piemonti L Calori G Mercalli A | 2003 | Diabetes Care2003，26，： | 1 |
| 3 | Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein-1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality 显示文摘 | Piemonti L Calori G Mercalli A | 2003 | Diabetes Care2003，26，10： | 1 |
| 4 | Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women:impact on cardiovascular mortality显示文摘 | Piemonti L Calori G Mercalli A | 2003 | Diabetes Care2003，26，10： | 1 |
| 5 | A preclinical evaluation of pemetrexed and irinotocan combination as second-line chemotherapy in pancreatic cancer显示文摘 | Mercalli A Sordi V Formicola R | 2007 | BrJ Cancer2007，96，5： | 1 |
| 6 | Rapamycin impairs antigen uptakes of human dendritic cells 显示文摘 | Monti P Mercalli A Leone BE | 2003 | Transplantation2003，75，： | 1 |
| 7 | Autophagy-active Beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas显示文摘 | Nicotra G Mercalli F Peracchio C | 2010 | Mod Pathol2010，23，7： | 1 |
| 8 | Bone marrow as analternative site for islet transplantation显示文摘 | Cantarelli E Melzi R Mercalli A | 2009 | Blood2009，114，20： | 1 |
| 9 | A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer 显示文摘 | Mercalli A Sordi V Formicola R | | Br J Cancer0，96，9： | 1 |
| 10 | Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function显示文摘 | Sordi V Melzi R Mercalli A | 2010 | Stem Cells2010，28，1： | 1 |
| 11 | Fasting plasma leptin, tumor ecrosisfactor-alpha receptor, and monocyte chemoattracting protein I concen-tration in a population of glucose-tolerant and glucose-intolerant women : impact on cardiovascular rtality显示文摘 | Piemonti L Calori G Mercalli A | 2003 | Diabetes Care2003，26，： | 1 |
| 12 | Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lym-phomas 显示文摘 | Nicotra G Mercalli F Peracchio C | 2010 | Mod Pathol2010，23，7： | 1 |
| 13 | A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer显示文摘 | Mercalli A Sordi V Formicola R | | 0，，： | 1 |
| 14 | Nephrogenic adenoma: a report of 3 unusual cases infiltrating into perinephric adipose tissue显示文摘 | Diolombi M Ross H M Mercalli F | 2013 | Am J Surg Pathol2013，37，4： | 1 |
| 15 | Rapamycin impairs antigen uptake of human dendritic cells显示文摘 | Monti P Mercalli A Leone BE | 2003 | Transplantation2003，75，1： | 1 |
| 16 | Fasting plasma leptin,tumor necrosis factor-alpha receptor 2,and monocyte chemoat trading protein 1 concentration in a population of glucose-tolerant and glucose intolerant women:impact on cardiovascular mortality显示文摘 | Piemonti L Calori G Mercalli A | 2003 | Diabetes Care2003，26，5： | 1 |
| 17 | Rapamycin impairs antigen uptake of human dendritic cells 显示文摘 | Monti P Mercalli A Leone B E | 2003 | Transplantation2003，75，1： | 1 |
| 18 | Rapamycin impairs antigen uptake of human dendritic cells显示文摘 | Monti P Mercalli A Leone BE | 2003 | Transplantation2003，75，1： | 1 |
| 19 | Autophagy-active beclin-I correlates with favourable clinical outcome in non- Hodgkin lymphomas显示文摘 | Nieotra G Mercalli F Peracchio C | 2010 | Mod Pathol2010，23，7： | 1 |
| 20 | Key role of shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein 显示文摘 | Ghizzoni S Arighi E | 2001 | Oncogene2001，，： | 1 |
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