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| 1 | Covert hepatic encephalopathy: Agreement and predictive validity of different indices显示文摘AIM:To investigate the agreement and prognosticvalue of different measures of covert hepatic encephalopathy(CHE).METHODS:One-hundred-and-thirty-two cirrhotic outpatients underwent electroencephalography(EEG),paper-and-pencil psychometry(PHES)and critical flicker frequency,scored on the original/modified(CFFo/CFFm)thresholds.Eighty-four patients underwent Dopplerultrasound to diagnose/exclude portal-systemic shunt.Seventy-nine were followed-up for 11±7 mo in relation to the occurrence of hepatic encephalopathy(HE)-related hospitalisations.RESULTS:On the day of study,36%had gradeⅠHE,42%abnormal EEG,33%abnormal PHES and 31/21%abnormal CFFo/CFFm.Significant associations were observed between combinations of test abnormalities;however,agreement was poor(Cohen’sκ<0.4).The prevalence of EEG,PHES and CFFo/CFFm abnormalities was significantly higher in patients with gradeⅠovert HE.The prevalence of EEG and CFFm abnormalities was higher in patients with shunt.The prevalence of EEG abnormalities was significantly higher in patients with a history of HE.During follow-up,10 patients died,10were transplanted and 29 had HE-related hospitalisations.GradeⅠHE(P=0.004),abnormal EEG(P=0.008)and abnormal PHES(P=0.04)at baseline all predicted the subsequent occurrence of HE;CFF did not.CONCLUSION:CHE diagnosis probably requires a combination of clinical,neurophysiological and neuropsychological indices. | Sara Montagnese Esmeralda Balistreri Sami Schiff Michele De Rui Paolo Angeli Giacomo Zanus Umberto Cillo Giancarlo Bombonato Massimo Bolognesi David Sacerdoti Angelo Gatta Carlo Merkel Piero Amodio | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | Incidence and natural history of small esophageal varices in cirrhotic patients显示文摘 | Manuela Merli Giorgia Nicolini Stefania Angeloni Vittorio Rinaldi Adriano De Santis Carlo Merkel Adolfo Francesco Attili Oliviero Riggio | 2002 | Journal of Hepatology2002，，3： | 4 |
| 3 | Sleep‐wake abnormalities in patients with cirrhosis显示文摘 | Sara Montagnese Cristiano De Pittà Michele De Rui Michela Corrias Matteo Turco Carlo Merkel Piero Amodio Rodolfo Costa Debra J. Skene Angelo Gatta | 2014 | Hepatology2014，，2： | 1 |
| 4 | Ploidy proliferative activity and prognosis DNA flow cytometry of solid tumor显示文摘 | Mc Guire WL | 1990 | Cancer1990，65，4： | 1 |
| 5 | Incidence and natural history of small esophageal varices in cirrhotic patients显示文摘 | Manuela Merli Giorgia Nicolini Stefania Angeloni Vittorio Rinaldi Adriano De Santis Carlo Merkel Adolfo Francesco Attili Oliviero Riggio | 2002 | Journal of Hepatology2002，，3： | 1 |
| 6 | Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis:a multicenter,randomized,placebo-controlled phase Ⅰ/Ⅱ trial of CAT-192显示文摘 | Denton CP Merkel PA Furst DE | 2007 | Arthritis Rheum2007，56，1： | 1 |
| 7 | Recombinant human anti- transforming growth factor betal antibody therapy in systemic sclero- sis: a muhicenter, randomized, placebo-controlled phase Ⅰ/Ⅱ trial of CAT-192 显示文摘 | Denton CP Merkel PA Furst DE | 2007 | Arthritis Rheum2007，56，： | 1 |
| 8 | Flow cytometry,cellular DNA content,and prognosis in human malignancy显示文摘 | Merkel DE Dressler LG McGuire WL | 1987 | JClin oncol1987，5，10： | 1 |
| 9 | Ploidy, proliferative activity and prognosi s (DNA flow cytometry of solid tumors)显示文摘 | Mcguire WL | 1990 | Cancer1990，65，： | 1 |
| 10 | Recombinant human anti-transforming growth factor betal antibody therapy in systemic sclero-sis: a multicenter,randomized,placebo-controlled phase I/II trial ofCAT-192显示文摘 | Denton CP Merkel PA Furst DE | 2007 | Arthritis Rheum2007，56，： | 1 |
| 11 | Ploidy proliferative activity and prognosis DNA flow cytometry of solid tumor显示文摘 | Merkel DE Mc Guire WL | 1990 | Cancer1990，65，4： | 1 |
| 12 | Ploidy,Proliferation activity and prognosis: DNA flow cytometry of solid tumors显示文摘 | MCGUIRE WL | 1990 | Cancer1990，65，5： | 1 |
| 13 | Ploidy,proliferative activity and prognosis-DNA flow cytometry of solid tumors显示文摘 | Merkel DE Mcguire WL | 1990 | Cancer1990，65，： | 1 |
| 14 | Ploidy,proliferative activity and prognosis: DNA flow cytometry of solid tumors显示文摘 | Merkel DE Mcguire WL | 1990 | Cancer1990，65，5： | 1 |
| 15 | Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis:a multicenter,randomized,placebo-controlled phase I/II trial of CAT-192显示文摘 | Denton CP Merkel PA Furst DE Khanna D Emery P Hsu VM | 2007 | Arthritis Rheum2007，56，1： | 1 |
| 16 | Recombinant humananti-transforming growth factor beta I antibody therapy in systemicsclerosis:a multicenter,randomized,placebo- controlledphase I/II trial of CAT-192显示文摘 | Denton CP Merkel PA Furst DE | 2007 | Arthritis Rheum2007，56，1： | 1 |
| 17 | Pregnancy and breast cancer显示文摘 | merkel DE | | 0，，05： | 1 |
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