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| 1 | New insights into renal lipid dysmetabolism in diabetic kidney disease显示文摘Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs,including the kidney.Research suggests that impaired cholesterol metabolism,increased lipid uptake or synthesis,increased fatty acid oxidation,lipid droplet accumulation and an imbalance in biologically active sphingolipids(such as ceramide,ceramide-1-phosphate and sphingosine-1-phosphate)contribute to the development of diabetic kidney disease(DKD).Currently,the literature suggests that both quality and quantity of lipids are associated with DKD and contribute to increased reactive oxygen species production,oxidative stress,inflammation,or cell death.Therefore,control of renal lipid dysmetabolism is a very important therapeutic goal,which needs to be archived.This article will review some of the recent advances leading to a better understanding of the mechanisms of dyslipidemia and the role of particular lipids and sphingolipids in DKD. | Alla Mitrofanova George Burke Sandra Merscher Alessia Fornoni | 2021 | World Journal of Diabetes2021，12，5： | 5 |
| 2 | Detailed map of a re- gion commonly amplified at llq13 - - > q14 in human breast carcinoma显示文摘 | Bekri S Adelaide J Merscher S | 1997 | Cytogenet Cell Genet1997，79，12： | 1 |
| 3 | Thx1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome显示文摘 | Merscher S Funke B Epstein JA | 2001 | Cell2001，104，： | 1 |
| 4 | The actin cy- toskeleton of kidney podoeytes is a direct target of' the antipro- teinurie effect of cyclosporine A 显示文摘 | Faul C Donnelly M Merscher - Gomez S | 2008 | Nat Med2008，14，9： | 1 |
| 5 | The actin cytoskeletonof kidney podocytes is a direct target of the antiproteinuric effect ofcyclosporine A显示文摘 | Faul C Donnelly M Merscher - Gomez S | 2008 | Nat Med2008，14，9： | 1 |
| 6 | Cyclodextrin protects podocytes in diabetic kidney disease显示文摘 | Merscher - Gomez S Guzman J Pedigo CE | 2013 | Diabetes2013，62，11： | 1 |
| 7 | Podocyte pathology and nephrop- athy-sphingolipids in glomerular diseases显示文摘 | Merscher S Fornoni A | 2014 | Front Endo- crinol (Lausanne)2014，5，5： | 1 |
| 8 | Detailed map of a region commonly amplified at 11q13-q14 in human breast carcinoma 显示文摘 | Bekri S Adelaide J Merscher S | 1997 | Cytogenet Cell Genet1997，79，12： | 1 |
| 9 | TBX1 is responsible for cardiovascular defects in velo-cardio-facial/ DiGeorge syndrome显示文摘 | Merscher S | 2001 | Cell Feb 232001，104，： | 1 |
| 10 | The ac-tin cytoskeleton of kidney podocytes is a direct target of the antipro-teinuric effect of cyclosporine A 显示文摘 | FAULC DONNELLY M MERSCHER GOMEZ S | 2008 | Nat Med2008，14，9： | 1 |
| 11 | TBX1 is responsible for car- diovascular defects in velo-cardiofacial/DiGeorge syndrome 显示文摘 | Merscher S Funke B Epstein JA | 2001 | Cell2001，104，4： | 1 |
| 12 | TBXI is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome显示文摘 | Merscher S Funke B Epstein JA Heyer J Puech A Lu MM Xavier RJ Demay MB Russell RG Factor S Tokooya K St.Jore B Lopez M Pandita RK Lia M Carrion D Xu H Schorle H Kobler JB Scambler P Wynshaw-Boris A Skoultchi AI Morrow BE Kucherlapati R | | 0，，04： | 1 |
| 13 | Detailed map of a re- gion commonly amplified at llq13 - - > q14 in human breast carcinoma显示文摘 | Bekri S Adelaide J Merscher S | 1997 | Cytogenet Cell Genet1997，79，12： | 1 |
| 14 | Detailed map of a region commonly amplified at 11q13-> q14 in human breast carcinoma 显示文摘 | Bekri S Adelaide J Merscher S | 1997 | Cytogenet Cell Genet1997，79，12： | 1 |
| 15 | TBX1 is responsible for cardiovascular defects in velo - cardio - facial / DiGeorge syndrome显示文摘 | Merscher S | 2001 | Cell Feb2001，104，4： | 1 |
| 16 | Detailed map of a region commonly amplified at 11q13--》q14 in human breast carcinoma显示文摘 | Bekri S Adelaide J Merscher S | | 0，，1： | 1 |
| 17 | The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A显示文摘 | Faul C Donnelly M Merscher GS et a1 | 2008 | Nat Med2008，14，9： | 1 |
| 18 | Sphingomyelin phosphodiesterase acid like 3B(SMPDL3b)regulates Perilipin5(PLIN5)expression and mediates lipid droplet formation显示文摘Lipid droplets(LDs)are lipid storage organelles with a central hydrophobic core of neutral lipids that is enclosed in a monolayer of phospholipids.Though the storage of lipids,mainly cholesterol and triglycerides,was thought to be the primary function of LDs,studies have shown that they have important functions in maintaining lipid homeostasis and modulating various signaling pathways.Abnormal lipid accumulation has been recognized as a key feature in several human diseases such as obesity,diabetes,cancer,neurological diseases,cardiovascular diseases,insulin resistance,liver diseases and kidney diseases.LDs play an important role in innate immunity,in the fight against infections,and in the replication of SARS-CoV-2.Hence a tight regulation of LD metabolism is essential for proper functioning of a cell. | Shamroop Kumar Mallela Mengyuan Ge Judith Molina Javier Varona Santos Jin-Ju Kim Alla Mitrofanova Hassan Al-Ali Brian Marples Sandra Merscher Alessia Fornoni | 2022 | Genes & Diseases2022，9，6： | 0 |
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