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| 1 | Role of surgery in colorectal cancer liver metastases显示文摘Colorectal carcinoma(CRC)is the third most common cancer,and approximately 35%-55%of patients with CRC will develop hepatic metastases during the course of their disease.Surgical resection represents the only chance of long-term survival.The goal of surgery should be to resect all metastases with negative histological margins while preserving sufficient functional hepatic parenchyma.Although resection remains the only chance of long-term survival,management strategies should be tailored for each case.For patients with extensive metastatic disease who would otherwise be unresectable,the combination of advances in medical therapy,such as systemic chemotherapy(CTX),and the improvement in surgical techniques for metastatic disease,have enhanced prognosis with prolongation of the median survival rate and cure.The use of portal vein embolization and preoperative CTX may also increase the number of patients suitable for surgical treatment.Despite current treatment options,many patients still experience a recurrence after hepatic resection.More active systemic CTX agents are beingused increasingly as adjuvant therapy either before or after surgery.Local tumor ablative therapies,such as microwave coagulation therapy and radiofrequency ablation therapy,should be considered as an adjunct to hepatic resection,in which resection cannot deal with all of the tumor lesions.Formulation of an individualized plan,which combines surgery with systemic CTX,is a necessary task of the multidisciplinary team.The aim of this paper is to discuss different approaches for patients that are treated due to CRC liver metastasis. | ?zgür Akgül Erdin? ?etinkaya ?iyar Ers?z Mesut Tez | 2014 | World Journal of Gastroenterology2014，20，20： | 40 |
| 2 | Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection显示文摘AIM To evaluate the prognostic significance of neutrophilto-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), lymphocyte-to-monocyte ratio(LMR), and prognostic nutritional index(PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer.METHODS183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels(CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival(months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database. The primary outcome measure was overall survival.RESULTS Regarding overall survival, on univariate analysis the following variables were significantly associated with poor outcome following resection: T-stage(P = 0.037), lymph node invasion(P = 0.037), cancer stage(P = 0.034), CEA(P = 0.042), CA19-9(P = 0.004), and PNI(P = 0.001). To evaluate the independent prognostic value, multivariate Cox proportional hazard analysis to control for other prognostic factors was used. Using cancer-specific death as an end point for NLR, PLR, LMR, PNI and CA19-9 the optimal cut off values were calculated by ROC analysis. Regarding overall survival, on multivariate analysis high CA19-9(HR = 1.001, 95%CI: 1.00-1.002, P = 0.012) and low PNI(HR = 0.938, 95%CI: 0.891-0.987, P = 0.014) were the only variables independently associated with shortened overall survival. Patients with a PNI < 35 had a median OS of 52.25 mo. In contrast, patients with an PNI > 35 had a median OS of 66 mo. Patients with a CA 19-9 < 17 had a median OS of 66 mo and in patients with a CA19-9 > 17 had a median OS of 53.76 mo.CONCLUSION This study shows that decrease in the PNI and increase in CA 19-9 is associated with poor survival in patients with resectable colon cancer. | özgür Akgül Erdinc Cetinkaya Metin Yalaza Sabri özden Mesut Tez | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 11 |
| 3 | Overcurrent Protection on Volt- age-source-converter Based Multiterminal DC Distribution Sys- tems显示文摘 | MESUT E B NIKHIL R M | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 4 | Anatomical dimensions of ante- rior bundle of ulnar collateral ligament and its role in elbow stability 显示文摘 | Gurbuz H Kutoglu T Mesut R | 2005 | Folia Med (Plovdiv)2005，47，1： | 1 |
| 5 | Anatomical dimensions of ante- rior bundle of ulnar collateral ligament and its role in elbow stability 显示文摘 | Gurbuz H Kutoglu T Mesut R | 2005 | Folia Med (Plovdiv)2005，1，： | 1 |
| 6 | Overcurrent protection on voltage-source-converter-based multiter- minal DC distribution systems显示文摘 | Mesut E Baran Nikhil R Mahajan | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 7 | Anatomical dimensions of ante- rior bundle of ulnar collateral ligaxaent and its role in elbow stability 显示文摘 | Ourbuz H Kutoglu T Mesut R | 2005 | Folia Med (Plovdiv)2005，1，： | 1 |
| 8 | Overcurrent protection onvoltage-source-converter-based multi-terminal DC distribution systems显示文摘 | Mesut E B Nikhil R M | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 9 | DC distribution for industrial systems: opporttmities and challenges显示文摘 | Mesut E Baran Nikhil R Mahajan | 2003 | IEEE Transactions on Industry Applications2003，39，6： | 1 |
| 10 | Anatomical dimensions of anterior bundle of ulnar collateral ligament and its role in elbow stability显示文摘 | Gurbuz H Kutoglu T Mesut R | 2005 | Folia Med (Plovdiv)2005，47，1： | 1 |
| 11 | Anatomical dimensions of anterior bundle of ulnar collateral ligament and its role in elbow stability 显示文摘 | Gurbuz H Kutoglu T Mesut R | 2005 | Folia Med (Plovdiv)2005，47，1： | 1 |
| 12 | NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel disease显示文摘 | Senem Ceren ?zen ülkü Da?l? Mesut Yalin Kili? Murat T?rüner Yasemin ?elik Muhip ?zkan Irfan Soykan Hülya ?etinkaya Aysel ülker Ali ?zden A. Mithat Bozday? | 2006 | Journal of Gastroenterology2006，，4： | 1 |
| 13 | Anatomical di- mensions of anterior bundle of ulhar collateral liga- ment and its role in elbow stability 显示文摘 | Gurbuz H Kutoglu T Mesut R etal | 2005 | Folla Med (plovdiv)2005，47，1： | 1 |
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