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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Male zebrafish (Danio rerio) courtship behaviour resists the feminizing effects of 17α-ethinyloestradiol -morphological sexual characteristics do not 显示文摘 | Mia G L Katrine B H Per G H | 2008 | Aquatic Toxicology2008，87，4： | 1 |
| 3 | Peripheral blood regulatory T cell measurements correlate with serum vita- min D levels in patients with multiple sclerosis 显示文摘 | ROYAL W 3RD MIA Y LI H | 2009 | J Neuroimmunol2009，213，12： | 1 |
| 4 | Cell death induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin(2,3,7,8-TCDD)in AtT-20 pituitary cells显示文摘 | PING H ROSHAN T MIA E | 2005 | Toxicology2005，207，： | 1 |
| 5 | Earthquake devastation and recovery in tourism:The Taiwan case显示文摘 | Huang J H Mia J C H | 2002 | Tourism Management2002，23，2： | 1 |
| 6 | Rhizobium as a crop enhancer and biofertilizer for increased cereal production显示文摘 | Baset Mia M A Shamsuddin Z H | 2010 | African J Biotechnol2010，9，37： | 1 |
| 7 | Relationship between tinnitus severity and psychiatric disorders显示文摘 | Sigyn Z Jan S Kajsa Mia H | 2006 | Psychosomatics2006，47，28： | 1 |
| 8 | Interleukin-17 Immunity in Pediatric Crohn Disease and Ulcerative Colitis显示文摘 | Veera H?ltt? Paula Klemetti Harri M. Salo Antti Koivusalo Mikko Pakarinen Mia Westerholm-Ormio Kaija-Leena Kolho Outi Vaarala | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，3： | 1 |
| 9 | Primary Biliary Cirrhosis is More Severe in Overweight Patients显示文摘 | Mia Híndi Cynthia Levy Claudia A. Couto Pablo Bejarano Flavia Mendes | 2013 | Journal of Clinical Gastroenterology2013，，3： | 1 |
| 10 | A fast method for robust principal components with applications to chemometrics 显示文摘 | MIA H PETER J SABINE V | 2002 | Chemometrics and Intelligent Laboratory Systems2002，60，： | 1 |
| 11 | Effect of plant growth promoting rhizobacterial (PGPR) inoculation on growth and nitrogen incorporation of tissue-cultured Musa plantlets under nitrogen-free hydroponics condition显示文摘 | Mia M A Baset Shamsuddin Z H Wahab Z Marziah M | 2010 | Australian Journal of Crop Science2010，，2： | 1 |
| 12 | In vitro evaluation of microcrystalline chitosan ( MCCh ) as gel forminge-xcipient in matrix granules 显示文摘 | MIA S ULRIKA S PAULA H | 2002 | Eur J Pharm Biopharm2002，54，： | 1 |
| 13 | Viscosity Loss in PF- PE Lubricant for Space Applications under EHL Conditions 显示文摘 | Mia S Komiya H Hayashi S | 2007 | Tribology Online2007，2，2： | 1 |
| 14 | Anal Chem显示文摘 | Sun B Qi H L Ma F Gao Q Zhang C X Mia W J | 2010 | 82:50462010，82，： | 1 |
| 15 | Effect of sintering time on the physical and electrochemical properties of LiFePO4/C composite cathodes 显示文摘 | MIA C H ZHANG X G ZHAO X B | 2006 | J Alloys and Compounds2006，424，： | 1 |
| 16 | High yielding and quality banana production through plant growth promoting rhizobacterial inoculation显示文摘 | Mia M A B Shamsuddin Z H Zakaria W et ol | 2005 | Fruits2005，60，： | 1 |
| 17 | Comparison of methods for DNA extraction from paraffin-embedded tissues and buccal cells显示文摘 | Wei C Mia H Jian Y | 2003 | Cancer Detection and Prevention2003，27，5： | 1 |
| 18 | Peripheral blood regulatory T cell measurements eorrelate with serum vitamin D levels in patients with multiple sclerosis显示文摘 | Royal W Mia Y Li H | 2009 | J Neuroimmunol2009，213，12： | 1 |
| 19 | Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis 显示文摘 | Royal W Mia Y Li H | 2009 | J Neuroimmunol2009，213，12： | 1 |
| 20 | Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?显示文摘 | Satu Pekkala Petri K. Wiklund Juha J. Hulmi Juha P. Ahtiainen Mia Horttanainen Eija P?ll?nen Kari A. M?kel? Heikki Kainulainen Keijo H?kkinen Kai Nyman Markku Alén Karl‐Heinz Herzig Sulin Cheng | 2013 | The Journal of Physiology2013，，21： | 1 |
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