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| 1 | Nuclear β-catenin expression as a prognostic factor in advanced colorectal carcinoma显示文摘AIM: To investigate the changing pattern of β-catenin expression and its prognostic value in advanced colorectal cancer (CRC). METHODS: Archival tumor samples were analyzed for β-catenin using immunohistochemistry (IHC) in 95 patients with advanced CRC. RESULTS: Membranous β-catenin expression was found in the normal colorectal epithelium. Almost 100% of CRC cases showed membranous and cytoplasmic expression,and 55 (58%) cases showed nuclear expression. In univariate (Kaplan-Meier) survival analysis,only the nuclear index (NI) was a signifi cant predictor of disease-free survival (DFS) (P = 0.023; n = 35),with a NI above the median associated with longer DFS (34.2 mo) than those with a NI below the median (15.5 mo) (P = 0.045,ANOVA). The other indices were not significant predictors of DFS,and none of the three tested indices (for membranous,cytoplasmic,or nuclear expression) predicted disease-specific survival (DSS). However,when dichotomized as positive or negative nuclear expression,the former was a signifi cant predictor of more favorable DFS (P = 0.041) and DSS (P = 0.046). CONCLUSION: Nuclear β-catenin expression provides additional information in predicting patient outcome in advanced CRC. | Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，24： | 13 |
| 2 | Cell Wall Lignin is Polymerised by Class Ⅲ Secretable Plant Peroxidases in Norway Spruce显示文摘Class Ⅲ secretable plant peroxidases occur as a large family of genes in plants with many functions and probable redundancy. In this review we are concentrating on the evidence we have on the catalysis of lignin polymerization by class Ⅲ plant peroxidases present in the apoplastic space in the xylem of trees. Some evidence exists on the specificity of peroxidase isozymes in lignin polymerization through substrate specificity studies, from antisense mutants in tobacco and poplar and from tissue and cell culture lines of Norway spruce (Picea abies) and Zinnia elegans. In addition, real time (RT-)PCR results have pointed out that many peroxidases have tissue specific expression patterns in Norway spruce. Through combining information on catalytic properties of the enzymes, on the expression patterns of the corresponding genes, and on the presence of monolignols and hydrogen peroxide in the apoplastic space, we can show that specific peroxidases catalyze lignin polymerization in the apoplastic space of Norway spruce xylem. | Kurt V.Fagerstedt Eija M.Kukkola Ville V.T.Koistinen Junko Takahashi Kaisa Marjamaa | 2010 | Journal of Integrative Plant Biology2010，52，2： | 12 |
| 3 | Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence显示文摘AIM: To investigate the prognostic value of CD44 variant 6 (CD44v6), a membranous adhesion molecule, in rectal cancer. METHODS: Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy (RT, n = 90), long-course (chemo) RT (n = 53) or surgery alone (n = 71) were studied with immunohistochemistry for CD44v6. The extent and intensity of membranous and cytoplasmic CD44v6 staining, and the intratumoral membranous staining pattern, were analyzed.RESULTS: Membranous CD44v6 expression was seen in 84% and cytoplasmic expression in 81% of the cases. In 59% of the tumors with membranous CD44v6 expression, the staining pattern in the invasive front was determined as 'front-positive' and in 41% as 'front-negative'. The latter pattern was associated with narrower circumferential margin (P = 0.01), infiltrative growth pattern (P < 0.001), and shorter disease-free survival in univariate survival analysis (P = 0.022) when compared to the 'front-positive' tumors. CONCLUSION: The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease. | Suvi Tuulia Avoranta Eija Annika Korkeila Kari Juhani Syrjnen Seppo Olavi Pyrhnen Jari Toivo Tapio Sundstrm | 2012 | World Journal of Gastroenterology2012，18，33： | 9 |
| 4 | Oxycodone显示文摘 | Eija Kalso | 2005 | Journal of Pain and Symptom Management2005，，5： | 2 |
| 5 | Enhanced BDNF Signaling is Associated with an Antidepressant-like Behavioral Response and Changes in Brain Monoamines显示文摘 | Eija K Tomi R Vootele V | 2005 | Cell Mol Neurobiol2005，25，6： | 1 |
| 6 | General competencies of problem-base learning (PBL)and non-PBL graduates显示文摘 | Katinka JAH Prince Patrick WLJ van Eija Henny PA Boshuizen | 2005 | Medical Education2005，，39： | 1 |
| 7 | Home care personnel’s perspectiveson successful discharge of elderly clients from hospital to homesetting 显示文摘 | Eija G Marja -Leena P | 2005 | Scand J Caring Sci2005，19，3： | 1 |
| 8 | General competencies of problem- base larning(PBL) and non-PBL graduates显示文摘 | katinka JAH Prince Patrick WLJ van Eija Henny PA Boshuizen | 2005 | Medical Education2005，39，39： | 1 |
| 9 | Cultures of human embryonic stem cells: serum replacement medium or serum-containing media and the effect of basic fibroblast growth factor显示文摘 | Heidi Koivisto Marjukka Hyv?rinen Anne-Marie Str?mberg Jose Inzunza Eija Matilainen Milla Mikkola Outi Hovatta Heli Teerijoki | 2004 | Reproductive BioMedicine Online2004，，3： | 1 |
| 10 | Ragiofrequency 天 enervation for neck an天 back pain:A systematic review within the framework of the cochrane collaboration back review group显示文摘 | Leena N Eija K Antti M | | 0，，： | 1 |
| 11 | Neurogenic Pulmonary Edema in Patients with Nontraumatic Intracerebral Hemorrhage: Predictors and Association with Outcome显示文摘 | Eija Junttila Tero Ala-Kokko Pasi Ohtonen Anne Vaarala Ari Karttunen Olli Vuolteenaho Tuula Salo Meeri Sutinen Toni Karhu Karl-Heinz Herzig Juha Koskenkari | 2013 | Anesthesia & Analgesia2013，，4： | 1 |
| 12 | Adults face increased asthma risk after infant RSV bronchiolitis and reduced respiratory health-related quality of life after RSV pneumonia显示文摘 | Katri B Eija PS Hertta O | 2013 | Acta Paediatr2013，103，8： | 1 |
| 13 | Up-regulation of α-catenin is associated with increased lymph node involvement in colorectal cancer显示文摘AIM: To investigate the changing pattern of α-catenin expression and its relationship to clinical and pathological features of colorectal cancer (CRC) patients. METHODS: Archival tumor samples were analyzed using immunohistochemistry (IHC) for α-catenin in 91 patients with advanced CRC. RESULTS: The values of α-catenin membrane index (MI) and cytoplasmic index (CI) were significantly related to the depth of tumor invasion (P = 0.027, P = 0.020, respectively), high indices being associated with increased depth of the primary tumor invasion (T3 and T4). Similarly, patients with high α-catenin expression had a signifi cantly increased risk of lymph node metastasis (32/39 vs 37/52 for MI and 37/45 vs 32/46 for CI) (P = 0.001, P = 0.0001, respectively, for LNN status). An altered expression (i.e., cytoplasmic pattern) was also related (P = 0.047) to the response to chemotherapy; patients with low CI were more responsive (CR: 7/46) than patients with high CI values (CR: 0/45). There was a marginal effect on survival in patients time with metastases (SWM) (P = 0.087); patients with low CI showing slightly longerSWM, but no such effect on disease free survival (DFS) or disease specifi c survival (DSS). As to co-expression with another member of the adhesion complex (β-catenin), high α-catenin/β-catenin MI index was of marginal signifi cance in predicting longer DSS (P = 0.063, log-rank). CONCLUSION: The results implicate that high α-catenin expression is intimately involved in the key regulatory mechanisms leading to invasive phenotype, lymph node metastases, and progressive disease in CRC. | Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，31： | 1 |
| 14 | Controlled-release oxycodone and morphine in cancer related pain显示文摘 | Tarja Heiskanen Eija Kalso | 1997 | Pain1997，，1： | 1 |
| 15 | A real-time PCR assay for rapid detection and quantitation of canine parvovirus type 2 in the feces of dog显示文摘 | Decaron Eija G Martellav | 2005 | Vet Microbiol2005，105，1： | 1 |
| 16 | General competencies of problem-base learning(PBL) and non-PBL graduates显示文摘 | Katinka JAH Prince Patrick WLJ van Eija Henny PA Boshuizen | 2005 | Medical Education2005，，39： | 1 |
| 17 | EU COST Action 628:life cycle assessment (LCA) of textile products,eco-efficiency and definition of beet awilahle technology (BAT) of textile processing显示文摘 | EIJA Nieminen MICHAEL Linke MARION Tobler | 2007 | Journal of Cleaner Production2007，15，1314： | 1 |
| 18 | Low plasma ghrelin is associated with insulin resistance,hypertension,and the prevalence of type 2 diabetes显示文摘 | Seppo M P Eija K Sohvi H | 2003 | Diabetes2003，52，10： | 1 |
| 19 | Endometriai K-ras mutationsin postmenopausal breast cancer patients treated with adjuvant tamoxifen or toremffene显示文摘 | Mika Walle n Eija Toma s etc | 2005 | Cancer Chemother Pharmacol2005，17，55： | 1 |
| 20 | The Meaning of living with traumatic brain injury in people with moderate or severe traumatic brain injury显示文摘 | Eija Jumisko Jan Lexen Siv Soderberg | 2005 | J Neurosci Nurs2005，37，1： | 1 |
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