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| 1 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 2 | Late Quaternary palaeoenvironmental changes documented by microfaunas and shell stable isotopes in the southern Pearl River Delta plain,South China显示文摘Ahigh resolution study of sediments,microfaunas(ostracods and foraminifers),and stable isotopes of ostracod shells from core PRD05,sampled from the Da’ao plain of the Pearl River Delta,provides new data about palaeoenvironmental changes during the Late Quaternary.The basal fluvial gravelly sediments of the core,representing the lowest deposits of the Quaternary at the core site,were possibly formed prior to the transgression associated with the last interglacial stage.This fluvial setting changed into a marginal marine setting during the last interglacial stage,any record of calcareous fossils were destroyed by subsequent dissolution during the last glacial phase,when the upper part of the deltaic sediments experienced subaerial oxidation,indicated by a mottled clay layer in the core.The postglacial sealevel rise in the South China Sea began at16,700 cal yr B.P.During the first phase of sea-level rise(from ~16,700 to 10,100 cal yr B.P.),a swamp environment developed at the core site.At ~10,100 cal yr B.P.,marine waters intruded onto the Da’ao plain and reached the core site through the Modaomen channel.This timing was earlier than in other parts of the Pearl River Delta.Since then,a semi-enclosed estuarine environment developed and was maintained until ~5560 cal yr B.P.During this transgressive interval,short-term environmental fluctuations can be recognized based on microfauna and shell geochemical data.From ~10,100 to 8630 cal yr B.P.,the sea-level rose,which was followed by a fall from ~8630 to 8520 cal yr B.P.An expanded transgression occurred between ~8520 and 7900 cal yr B.P.The time intervals from ~8520 to 8200 cal yr B.P.and from ~8080 to 7900 cal yr B.P.were marked by peak transgression.From ~7900 to 5560 cal yr B.P.,the core site generally showed a reduced marine influence and enhanced freshwater input.A fluvial environment developed from ~5560 to 3100 cal yr B.P.,and was succeeded by an alluvial plain setting. | Liu Chunlian Franz T. Fürsich Wu Jie Dong Yixin Yang Tingting Yin Jian | 2013 | Journal of Palaeogeography2013，2，4： | 8 |
| 3 | Joint identification of plant rational models and noise distribution functions using binary-valued observations显示文摘 | WANG L Y YIN G G ZHANG J F | 2006 | Automatica2006，42，4： | 1 |
| 4 | Chemical characterization of tribochemical and thermal films generated from neutral and basic ZDDPs using X - Ray Absorption Spectroscopy 显示文摘 | Fuller M Yin Z F Kasrai M | 1997 | Tribology International1997，30，4： | 1 |
| 5 | Mouse salivary glands and human beta-defensin-2 as a study model for antimicrobial gene therapy:technical considerations显示文摘 | YIN C DANG H N GAZOR F | 2006 | Int J Antimicrob Agents2006，28，4： | 1 |
| 6 | Family average income and diagnosed type 2 diabetes among urban and rural Residents in Regional Mainland China显示文摘 | Xu F Yin XM Zhang M | 2006 | Diabet Med2006，23，： | 1 |
| 7 | Removal of phosphateby mesoporous ZrO2显示文摘 | Liu H L Sun X F Yin C Q | 2008 | J Hazard Mater2008，151，23： | 1 |
| 8 | Large - scale fabrication of tower - like,flower- like, and tube- like ZnO arrays by a simple chemical solution route 显示文摘 | WANG Z QIAN X F YIN J | 2004 | Langmuir2004，20，8： | 1 |
| 9 | LPA and SIP increase corneal ep- ithelial and endothelial cell transeellularresistance显示文摘 | Yin F Watsky MA | 2005 | Investigative ophthalmology By- visual science2005，46，6： | 1 |
| 10 | Internal friction of Niobium-TitaniumOxygen alloys显示文摘 | Yu L M Yin F X | 2007 | Journal of Materials Science2007，42，18： | 1 |
| 11 | Space and time complexities and sensor threshold selection in quantized identification显示文摘 | Wang L Y Yin G G Zhang J F Zhao Y L | | 0，，12： | 1 |
| 12 | Structure optimization of ruthenium photo- sensitizers for efficient dye-sensitized solar cells-a goal toward a 'bright' future显示文摘 | YIN J F VELAYUDHAM M BHATTACHARYA D | 2012 | Coordination Chemical Reviews2012，256，： | 1 |
| 13 | A region-growing permutation alignment approach in frequency-domain blind source separation of speech mixtures 显示文摘 | Wang L Ding H Yin F | 2011 | IEEE Transactions on Audio Speech and Language Processing2011，19，3： | 1 |
| 14 | Time-Resolved Electronic Phase Transitions in Manganites 显示文摘 | Ward T Z Zhang X G Yin L F | 2009 | Phys Rev Lett2009，102，： | 1 |
| 15 | Luminescence properties of Dy3+-doped Li2Sr Si O4for NUV-excited white LEDs显示文摘 | You P L Yin G F Chen X C | 2011 | Opt Mater2011，33，11： | 1 |
| 16 | Highly selective colorimetric and fluorescent sensors for the fluor- ide anion based on imidazo -1, 10-phenanthroline metal-complexes显示文摘 | Li S Zhang C Huang S Hu F Yin J Liu S H | 2012 | RSC Advances2012，2，10： | 1 |
| 17 | Effects of salt concentrationon biogenic amine formation and quality changes in grass carp(Ctenopharyngodon idellus) fillets stored at 4 and 20 °C显示文摘 | WANG H LUO Y K YIN X F | 2014 | Journal ofFood Protection2014，77，5： | 1 |
| 18 | Dynamic reduction-based structural damage detection of transmission tower utilizing ambient vibration data 显示文摘 | Yin T Lam H F Chow H M | 2009 | Engineering Structures2009，31，9： | 1 |
| 19 | Positive periodic solutions of a single spe- cies model with feedback regulation and distributed time delay显示文摘 | Yin F Q Li Y K | 2004 | Appl Math Comput2004，，153： | 1 |
| 20 | Development and trend analysis of meter reading system 显示文摘 | Shi Y F Cai H G Yin J H | 2009 | Technical Wind2009，16，： | 1 |
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