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| 1 | Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis显示文摘AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 patients with PBC were tested by enzyme-linked immunosorbent assay against 33 synthetic overlapping peptides (25 amino acids; aa) covering the entire length of the E2-subunit of PDC-E2. Furthermore,the inner lipoyl peptide 167-184 was used in an unlip oylated and a lipoylated form as well as coupled to ovalbumin. Sera from 11 AMA negative/ANA posit ive PBC patients,63 patients with other liver disorders and 22 healthy blood donors served as controls.RESULTS:Of the 95 PBC-sera,74% reacted with the peptide 475-499 and 58% with the pept ide 407-431 located within the catalytic domain of PDC-E2. Patients with other disorders or healthy controls were positive in only up to 18%. Antibodies to the unlipoylatedand lip oylated pept ide 167-184 within the inner lipoyl domain were found in only 5% and 11% of the PBC sera,respectively; using ovalbumin-coupled peptides,the incidence increased up to 57% (unlipoylated form). CONCLUSION:Peptides within the catalytic site of PDC-E2 rather than the previously reported lipoyl binding peptide 167-184 may represent major immunodomin ant epitopes recognized by AMA in PBC. | Sandra Braun Christoph Berg Sandra Buck Michael Gregor Reinhild Klein | 2010 | World Journal of Gastroenterology2010，16，8： | 13 |
| 2 | 甘油氧化的光谱电化学傅里叶变换衰减全反射谱红外光谱薄膜流动池中硼酸镍层厚度的优化显示文摘在碱性甘油电氧化反应中,利用电化学傅里叶变换衰减全反射谱红外光谱法,研究了薄膜流动池中滴注硼酸镍催化剂负载量对玻碳电极性能的影响.连续操作的径向流动池包括一个位于内反射元件上方50μm的钻孔电极,可实现红外光谱分析.这是在确定条件下对电催化剂进行简便和可重复筛选的一个适合的方法,同时还提供了对复杂反应(如甘油氧化)产物选择性的检测.通过对泵送电解液进行更耗时的定量高效液相色谱分析,结果表明,衰减全反射红外光谱法可快速鉴定产物.在层流条件下,水中使用0.1 M甘油和1 M KOH,流速为5μL min^(-1)时,甘油转化率较高.转化率和选择性取决于催化剂的负载量,负载量又决定了催化剂层的厚度和粗糙度.由于在更粗糙的膜中停留时间更长有利于再吸附和C-C键断裂,因此当负载量最高达210μg cm^(-2)时,甘油转化率为73%且甲酸选择性接近80%.当最低负载量为13μg cm^(-2)时,甘油转化率达到63%,甲酸选择性降至60%,相应地,C_(2)物种(如乙醇酸盐)选择性较高,为8%.因此,只有催化剂负载量较低时才能形成几微米厚度范围内的薄膜,此时才适合进行优质催化剂的筛选. | Steffen Cychy Sebastian Lechler Zijian Huang Michael Braun Ann Cathrin Brix Peter Blümler Corina Andronescu Friederike Schmid Wolfgang Schuhmann Martin Muhler | 2021 | Chinese Journal of Catalysis2021，42，12： | 2 |
| 3 | 模块组合多电平变换器的一种新型低频运行控制方法显示文摘本文提出一种可实现模块组合多电平变换器(MMC)低频甚至零频运行的控制策略,该技术使得MMC适合作为低频运行工况下的三相电机供电电源。共模电压和相应的内部电流确保能量在MMC的桥臂之间对称分布,并避免了直流电源侧出现交流电流分量。 | Johannes Kolb Felix Kammerer Michael Braun 杨晓峰 | 2011 | 电力电子2011，，6： | 2 |
| 4 | Prediction of cochlear implant performance by genetic mutation: The spiral ganglion hypothesis显示文摘 | Robert W. Eppsteiner A. Eliot Shearer Michael S. Hildebrand Adam P. DeLuca Haihong Ji Camille C. Dunn Elizabeth A. Black-Ziegelbein Thomas L. Casavant Terry A. Braun Todd E. Scheetz Steven E. Scherer Marlan R. Hansen Bruce J. Gantz Richard J.H. Smith | 2012 | Hearing Research (-)2012，，1： | 1 |
| 5 | Algae-environment relationships in an impoundment stretch of the River Grosse Erlauf (Austria) 显示文摘 | BRAUN Bernhard SCHAGERL Michael | 2010 | River Systems2010，19，1： | 1 |
| 6 | Obstacles to social networking website use among older adults 显示文摘 | Michael T Braun | 2013 | Computers in Hu- man Behavior2013，，29： | 1 |
| 7 | Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin 显示文摘 | Ruediger C Braun D Michael J | 2001 | Thromb Vasc Biol2001，21，7： | 1 |
| 8 | Organizational Decline and Innovation : Turnarounds andDownward Spirals显示文摘 | William McKinley Scott Latham Michael Braun | 2014 | Academy Management Review2014，39，1： | 1 |
| 9 | The Impact of Regret on the Demand for Insurance显示文摘 | Michael Braun Alexander Muermann | 2004 | The Journal of Risk and Insurance2004，71，4： | 1 |
| 10 | The Bioavailability of Apigenin-7-Glucoside Is Influenced by Human Intestinal Microbiota in Rats1-3显示文摘 | Hanske Laura Loh Gunnar Sczesny Silke Blaut Michael Braune Annett | 2009 | The Journal of Nutrition2009，，6： | 1 |
| 11 | Space-Based Visible Data Reduction 显示文摘 | Sharma Jayant von Braun Curt Gaposchkin Michael E | 2000 | Journal of Guidance Control and Dynamics2000，23，1： | 1 |
| 12 | Space-Based Visible Metric Accuracy 显示文摘 | von Braun Curt Sharma Jayant Gaposchkin Michael E | 2000 | Journal of Guidance Control and Dynamics2000，23，1： | 1 |
| 13 | space-based space surveillance with the space-based visible显示文摘 | Gaposchkin E Michael Braun Curt von Sharma Jayant | 2000 | Journal of Guidance Control and Dynamics(S0731-5090)2000，23，1： | 1 |
| 14 | Spaced-Based Spaced Surveillance with Spaced-Based Visible显示文摘 | E Michael Gaposchkin Curt von Braun | 2000 | Journal of Guidance Control and Dynamic(S0731-5090)2000，23，1： | 1 |
| 15 | Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection显示文摘 | Georgios N Dalekos Petra Obermayer-Straub Moritz Bartels Takashi Maeda Anne Kayser Sabine Braun Stephanie Loges Eleonore Schmidt M.Eric Gershwin Michael P Manns | 2003 | Journal of Hepatology2003，，5： | 1 |
| 16 | Obstacles to Social Networking Website Use among Older Adults显示文摘 | Michael T Braun | 2013 | Computers in Human Behavior2013，，29： | 1 |
| 17 | Clonidine Attenuated Early Proinflammatory Response in T-Cell Subsets After Cardiac Surgery显示文摘 | Vera von Dossow Nadine Baehr Maryam Moshirzadeh Christian von Heymann Jan P. Braun Ortrud V. Hein Michael Sander Klaus-D Wernecke Wolfgang Konertz Claudia D. Spies | 2006 | Anesthesia & Analgesia2006，，4： | 1 |
| 18 | Cell cycle progression new therapeutic target for vascular proliferative disease显示文摘 | Ruediger C Braun D Michael J | 1998 | Circulation1998，98，1： | 1 |
| 19 | Influence of the oxidation state of phosphorus on the decomposition and fire behaviour of flame-retarded epoxy resin composites显示文摘 | Ulrike Braun Aliaksandr I. Balabanovich Bernhard Schartel Uta Knoll Johannes Artner Michael Ciesielski Manfred D?ring Raul Perez Jan K.W. Sandler Volker Altst?dt Thorsten Hoffmann Doris Pospiech | 2006 | Polymer2006，，26： | 1 |
| 20 | Current perspective cell cycle progression new therapeutic target for vascular proliferative disease 显示文摘 | Braun D Michael J Mann VJ Dzau | 1998 | Circulation1998，98，： | 1 |
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