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| 1 | Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration显示文摘 | Marisol Cano Rajesh Thimmalappula Masashi Fujihara Norihiro Nagai Michael Sporn Ai Ling Wang Arthur H. Neufeld Shyam Biswal James T. Handa | 2009 | Vision Research2009，，7： | 1 |
| 2 | Electroanatomic Substrate and Ablation Outcome for Suspected Epicardial Ventricular Tachycardia in Left Ventricular Nonischemic Cardiomyopathy显示文摘 | Oscar Cano Mathew Hutchinson David Lin Fermin Garcia Erica Zado Rupa Bala Michael Riley Joshua Cooper Sanjay Dixit Edward Gerstenfeld David Callans Francis E. Marchlinski | 2009 | Journal of the American College of Cardiology2009，，9： | 1 |
| 3 | Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration显示文摘 | Marisol Cano Rajesh Thimmalappula Masashi Fujihara Norihiro Nagai Michael Sporn Ai Ling Wang Arthur H. Neufeld Shyam Biswal James T. Handa | 2009 | Vision Research2009，，7： | 1 |
| 4 | Anticancer activity of crude acetone and water extracts of Tulbaghia violacea on human oral cancer cells显示文摘Objective: To evaluate the anticancer activity of crude acetone and water leaf extracts of Tulbaghia violacea on a human oral cancer cell line(KB).Methods: The antioxidant activity of the leaf extracts was evaluated by using the DPPH assay while the anti-proliferative activity was assessed by using the MTT assay.The morphological characteristics of apoptotic cells were examined by using the dual acridine orange/ethidium bromide staining.Flow cytometry was used to evaluate the induction of multi-caspase activity and changes in the cell cycle.Results: The acetone and water extracts exhibited antioxidant activity in a concentration dependent manner.The extracts inhibited the growth of the KB cell line with IC_(50) values of 0.2 mg/mL and 1 mg/mL, respectively for acetone and water.Morphological changes such as cell shrinkage, rounding and formation of membrane blebs were observed in the treated cells.In acridine orange/ethidium bromide staining, the number of apoptotic cells increased as the concentration of the extracts increased.The activation of multi-caspase activity in KB cells treated with Tulbaghia violacea extracts was concentration dependent, leading to cell death by apoptosis and cell cycle arrest at the G_2/M phase.Conclusions: The acetone and water extracts of Tulbaghia violacea appear to have anti-cancer activity against human oral cancer cells and need to be investigated further. | Samkeliso Takaidza Arumugam Madan Kumar Cornelius Cano Ssemakalu Nagabishek Sirpu Natesh Gayathri Karanam Michael Pillay | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，9： | 0 |
| 5 | Evaluation of a deep learning supported remote diagnosis model for identification of diabetic retinopathy using wide-field Optomap显示文摘Background:We test a deep learning(DL)supported remote diagnosis approach to detect diabetic retinopathy(DR)and other referable retinal pathologies using ultra-wide-field(UWF)Optomap.Methods:Prospective,non-randomized study involving diabetic patients seen at endocrinology clinics.Non-expert imagers were trained to obtain non-dilated images using UWF Primary.Images were graded by two retina specialists and classified as DR or incidental retinal findings.Cohen’s kappa was used to test the agreement between the remote diagnosis and the gold standard exam.A novel DL model was trained to identify the presence or absence of referable pathology,and sensitivity,specificity and area under the receiver operator characteristics curve(AUROC)were used to assess its performance.Results:A total of 265 patients were enrolled,of which 241 patients were imaged(433 eyes).The mean age was 50±17 years,45%of patients were female,34%had a diagnosis of diabetes mellitus type 1,and 66%of type 2.The average Hemoglobin A1c was 8.8±2.3%,and 81%were on Insulin.Of the 433 images,404(93%)were gradable,64 patients(27%)were referred to a retina specialist,and 46(19%)were referred to comprehensive ophthalmologist for a referable retinal pathology on remote diagnosis.Cohen’s kappa was 0.58,indicating moderate agreement.Our DL algorithm achieved an accuracy of 82.8%(95%CI:80.3-85.2%),a sensitivity of 81.0%(95%CI:78.5-83.6%),specificity of 73.5%(95%CI:70.6-76.3%),and AUROC of 81.0%(95%CI:78.5-83.6%).Conclusions:UWF Primary can be used in the non-ophthalmology setting to screen for referable retinal pathology and can be successfully supported by an automated algorithm for image classification. | Terry Lee Mingzhe Hu Qitong Gao Joshua Amason Durga Borkar David D’Alessio Michael Canos Afreen Shariff Miroslav Pajic Majda Hadziahmetovic | 2022 | Annals of Eye Science2022，，2： | 0 |
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