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| 1 | Analysis of the phytochemical contents and antioxidant activities of crude extracts from Tulbaghia species显示文摘OBJECTIVE: To assess the phytochemical contents and antioxidant activities of crude extracts from selected Tulbaghia species.METHODS: Standard methods were used for preliminary phytochemical analysis. The total phenolic acid contents of the plant extracts were determined using the Folin-Ciocalteu method, and the total flavonoid contents were determined using the aluminum chloride colorimetric method. 1,1-Diphenyl-2-picrylhydrazyl and 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) assays were used to evaluate the antioxidant activities.RESULTS: Phytochemical screening showed flavonoids, glycosides, tannins, terpenoids, saponins,and steroids were present in the Tulbaghia species.The total phenolic acid and flavonoid contents varied in the different plant extracts, ranging from4.50 to 11.10 mg of gallic acid equivalents per gram of fresh material and 3.04 to 9.65 mg of quercetin equivalents per gram, respectively. The IC50 values determined for Tulbaghia alliacea and Tulbaghia violacea based on 1,1-diphenyl-2-picrylhydrazyl(0.06 and 0.08 mg/m L, respectively) and 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)(0.06 and 0.03 mg/m L, respectively) were low and showed they had potential antioxidant activities.CONCLUSION: Our results suggest that individual compounds from Tulbaghia species should be isolated for analysis of their antioxidant activity because some compounds may work best when pure. | Samkeliso Takaidza Fanyana Mtunzi Michael Pillay | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 2 |
| 2 | Nafcillin-loaded PLGA nanoparticles for treatment of osteomyelitis显示文摘 | Rajeev Raghavan Pillai Shankari N Somayaji Monica Rabinovich Michael C Hudson Kenneth E Gonsalves | 2008 | Biomedical Materials2008，，3： | 1 |
| 3 | Sperling Interictal EEG and the Diagnosis of Epilepsy显示文摘 | Jyoti Pillai Michael R | 2006 | Epilepsia2006，47，： | 1 |
| 4 | Outcome predictors in the management of spinal cord ependymoma显示文摘 | D. Gavin Quigley Naeem Farooqi Timothy J. D. Pigott Gordon F. G. Findlay Robin Pillay Neil Buxton Michael D. Jenkinson | 2007 | European Spine Journal2007，，3： | 1 |
| 5 | Neuro- vascular protection by targeting early blood - brain barrier disruption with neurotrophic factors after ischemia - reperfusion in rats 显示文摘 | Deepu R Pillai Nagesh C Shanbhag Michael S Dittmar | 2013 | Jour- nal of Cerebral Blood Flow & Metabolism2013，33，： | 1 |
| 6 | Effect of oxide dopants on densification, microstructure and mechanical properties of alumina-silicon carbide nanocomposite ceramics prepared by pressureless sintering显示文摘 | Sunil Kumar C. Pillai Benoit Baron Michael J. Pomeroy Stuart Hampshire | 2003 | Journal of the European Ceramic Society2003，，12： | 1 |
| 7 | Analysis of postrevascularization syndrome after orthotopic liver transplantation: the experience of an Australian liver transplantation center显示文摘 | Atsushi Nanashima Praga Pillay Michael Crawford Masato Nakasuji Deborah J. Verran Dorothy Painter | 2001 | Journal of Hepato - Biliary - Pancreatic Surgery2001，，6： | 1 |
| 8 | Recognition of 2′- O -Methylated 3′-End of piRNA by the PAZ Domain of a Piwi Protein显示文摘 | Bernd Simon John P. Kirkpatrick Stephanie Eckhardt Michael Reuter Elsa A. Rocha Miguel A. Andrade-Navarro Peter Sehr Ramesh S. Pillai Teresa Carlomagno | 2011 | Structure2011，，2： | 1 |
| 9 | A review on the visible light active titanium dioxide photocatalysts for environmental applications显示文摘 | Miguel Pelaez Nicholas T. Nolan Suresh C. Pillai Michael K. Seery Polycarpos Falaras Athanassios G. Kontos Patrick S.M. Dunlop Jeremy W.J. Hamilton J.Anthony Byrne Kevin O’Shea Mohammad H. Entezari Dionysios D. Dionysiou | 2012 | Applied Catalysis B: Environmental2012，，： | 1 |
| 10 | Effect of oxide dopants on densification, microstructure and mechanical properties of alumina-silicon carbide nanocompo-site ceramics prepared by pressureless sintering显示文摘 | Sunil Kumar C Pillai Benoit Baron Michael J Pomeroy | 2004 | J Eur Ceram Soc2004，24，12： | 1 |
| 11 | Success of Self-Administered Home Fecal Transplantation for Chronic Clostridium difficile Infection显示文摘 | Michael S. Silverman Ian Davis Dylan R. Pillai | 2010 | Clinical Gastroenterology and Hepatology2010，，5： | 1 |
| 12 | Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis显示文摘 | Ravindra K Gupta Michael R Jordan Binta J Sultan Andrew Hill Daniel HJ Davis John Gregson Anthony W Sawyer Raph L Hamers Nicaise Ndembi Deenan Pillay Silvia Bertagnolio | 2012 | The Lancet2012，，9849： | 1 |
| 13 | A timely review of state-of-the-art chronopharmaceuticals synchronized with biological rhythms显示文摘 | SESHNI SEWLALL VINESS PILLAY MICHAEL P | 2010 | Current Drug Delivery2010，，7： | 1 |
| 14 | Anticancer activity of crude acetone and water extracts of Tulbaghia violacea on human oral cancer cells显示文摘Objective: To evaluate the anticancer activity of crude acetone and water leaf extracts of Tulbaghia violacea on a human oral cancer cell line(KB).Methods: The antioxidant activity of the leaf extracts was evaluated by using the DPPH assay while the anti-proliferative activity was assessed by using the MTT assay.The morphological characteristics of apoptotic cells were examined by using the dual acridine orange/ethidium bromide staining.Flow cytometry was used to evaluate the induction of multi-caspase activity and changes in the cell cycle.Results: The acetone and water extracts exhibited antioxidant activity in a concentration dependent manner.The extracts inhibited the growth of the KB cell line with IC_(50) values of 0.2 mg/mL and 1 mg/mL, respectively for acetone and water.Morphological changes such as cell shrinkage, rounding and formation of membrane blebs were observed in the treated cells.In acridine orange/ethidium bromide staining, the number of apoptotic cells increased as the concentration of the extracts increased.The activation of multi-caspase activity in KB cells treated with Tulbaghia violacea extracts was concentration dependent, leading to cell death by apoptosis and cell cycle arrest at the G_2/M phase.Conclusions: The acetone and water extracts of Tulbaghia violacea appear to have anti-cancer activity against human oral cancer cells and need to be investigated further. | Samkeliso Takaidza Arumugam Madan Kumar Cornelius Cano Ssemakalu Nagabishek Sirpu Natesh Gayathri Karanam Michael Pillay | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，9： | 0 |
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