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| 1 | Severe adverse events during antiviral therapy in hepatitis C virus cirrhotic patients: A systematic review显示文摘AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles published prior to December 2011 in the PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases that presented these data in cirrhotic patients. These studies evaluated the rate of SAEs leading to discontinuation of standard care treatment: Pegylated interferon (PegIFN) alpha 2a (135-180 μg/wk) or PegIFN alpha 2b (1 or 1.5 μg/kg per week) and ribavirin (800-1200 mg/d). Patients with genotype 1 + 4 underwent treatment for 48 wk, whereas those with genotypes 2 + 3 were treated for 24 wk.RESULTS: We included 17 papers in this review, comprising of 1133 patients. Treatment was discontinued due to SAEs in 14.5% of the patients. The most common SAEs were: severe thrombocytopenia and/or neutropenia (23.2%), psychiatric disorders (15.5%), decompensation of liver cirrhosis (12.1%) and severe anemia (11.2%). The proportion of patients who needed to discontinue their therapy due to SAEs was significantly higher in patients with Child-Pugh class B and Cvs those with Child-Pugh class A: 22%vs 11.4% (P = 0.003). A similar discontinuation rate was found in cirrhotic patients treated with PegIFN alpha 2a and those treated with PegIFN alpha 2b, in combination with ribavirin: 14.2%vs 13.7% (P = 0.96). The overall sustained virological response rate in cirrhotic patients was 37% (95%CI: 33.5-43.1) but was significantly lower in patients with genotype 1 + 4 than in those with genotype 2 + 3: 20.5% (95%CI: 17.9-24.8) vs 56.5% (95%CI: 51.5-63.2), (P < 0.0001). CONCLUSION: Fourteen point five percent of HCV cirrhotic patients treated with PegIFN and ribavirin needed early discontinuation of therapy due to SAEs, the most common cause being hematological disorders. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Adriana Maria Neghinǎ Mirela Dǎnilǎ Mihnea Strǎin | 2013 | World Journal of Hepatology2013，5，3： | 6 |
| 2 | The role of exosomal long non-coding RNAs in cancer drug resistance显示文摘One of the major challenges in oncology is drug resistance,which triggers relapse and shortens patients’survival.In order to promote drug desensitization,cancer cells require the establishment of an ideal tumor microenvironment that accomplishes specific conditions.To achieve this objective,cellular communication is a key factor.Classically,cells were believed to restrictively communicate by ligand-receptor binding,physical cell-to-cell interactions and synapses.Nevertheless,the crosstalk between tumor cells and stroma cells has also been recently reported to be mediated through exosomes,the smallest extracellular vesicles,which transport a plethora of functionally active molecules,such as:proteins,lipids,messenger RNA,DNA,microRNA or long non-coding RNA(lncRNAs).LncRNAs are RNA molecules greater than 200 base pairs that are deregulated in cancer and other diseases.Exosomal lncRNAs are highly stable and can be found in several body fluids,being considered potential biomarkers for tumor liquid biopsy.Exosomal lncRNAs promote angiogenesis,cell proliferation and drug resistance.The role of exosomal lncRNAs in drug resistance affects the main treatment strategies in oncology:chemotherapy,targeted therapy,hormone therapy and immunotherapy.Overall,knowing the molecular mechanisms by which exosomal lncRNA induce pharmacologic resistance could improve further drug development and identify drug resistance biomarkers. | Mireia Cruz De los Santos Mihnea P.Dragomir George A.Calin | 2019 | Cancer Drug Resistance2019，2，4： | 3 |
| 3 | Targeting non-coding RNAs to overcome cancer therapy resistance显示文摘It is now well known that non-coding RNAs(ncRNAs),rather than protein-coding transcripts,are the preponderant RNA transcripts.NcRNAs,particularly microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),are widely appreciated as pervasive regulators of multiple cancer hallmarks such as proliferation,apoptosis,invasion,metastasis,and genomic instability.Despite recent discoveries in cancer therapy,resistance to chemotherapy,radiotherapy,targeted therapy. | BaoQing Chen Mihnea P.Dragomir Chen Yang Qiaoqiao Li David Horst George A.Calin | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 3 |
| 4 | Key questions about the checkpoint blockade-are microRNAs an answer?显示文摘The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change of the management of late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents are undergoing phase 2 and early phase 3 clinical trials. The therapeutic indication of immune checkpoint inhibitors expanded in the last years, but still remains unclear who can benefit. Micro RNAs are small RNAs with no coding potential. By complementary pairing to the 3' untranslated region of messenger RNA, microRNAs exert posttranscriptional control of protein expression. A network of microRNAs directly and indirectly controls the expression of checkpoint receptors and several microRNAs can target multiple checkpoint molecules,mimicking the therapeutic effect of a combined immune checkpoint blockade. In this review, we will describe the microRNAs that control the expression of immune checkpoints and we will present four specific issues of the immune checkpoint therapy in cancer:(1) imprecise therapeutic indication,(2) difficult response evaluation,(3) numerous immunologic adverse-events, and(4)the absence of response to immune therapy. Finally, we propose microRNAs as possible solutions for these pitfalls. We consider that in the near future microRNAs could become important therapeutic partners of the immune checkpoint therapy. | Mihnea Dragomir Baoqing Chen Xiao Fu George A.Calin | 2018 | Cancer Biology & Medicine2018，15，2： | 2 |
| 5 | Moidoveanu, On the Relationship Between Organizational Complexity and Organizational Structuration 显示文摘 | Mihnea C | 2004 | Organization Science2004，15，1： | 1 |
| 6 | 人类活动导致变化的内海:波罗的海与黑海之间的比较显示文摘本评论首次试图根据环境观点对波罗的海和黑海进行比较。这两个海都受到人类活动导致的变化的影响,并受到日益增加的富营养化和环境退化的严重威胁。这两个海都因物理屏障和生态屏障而与大洋隔绝。在冰期之后,这两个海都曾是淡水湖,如今它们都显示出成层条件。过去几十年内的这些变化可能与下列因素相关:污染、集水区内的大规模变化、生境退化、生物资源的过度开发和生物地理事件(新物种的建立和本地生物的灭绝)。我们提供了对初级生产、浮游植物、浮游动物、大型植物群落、大型底栖动物种群和鱼类群落中多源压力的反应之实例。从局部、地区和整个海盆尺度论述了这两个海的生态系统病理学症状及其应付压力的机制。 | Erkki Leppkoski Pia Elena Mihnea 张康生 | 1996 | 人类环境杂志1996，25，6： | 1 |
| 7 | Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and clAP1 in situ显示文摘 | Christina R Mihnea V Michael P | 2002 | Biol Chem2002，277，5： | 1 |
| 8 | The role of macrophage IL-10/innate IFN interplay during virus-induced asthma显示文摘 | Mihnea T Zdrenghea Heidi Makrinioti Adriana Muresan | 2015 | Rev Med Virol2015，25，1： | 1 |
| 9 | Deliberate external pancreatic fistula after pancreaticoduodenectomy performed in the setting of acute pancreatitis, and its internalization through fistula-jejunostomy显示文摘To the Editor:Many patients with tumors of the pancreatic head or of the ampulla of Vater require endoscopic manipulation of the duodenal papilla in order to achieve tumor biopsy or for common bile duct stenting.These interventional endoscopy approaches may lead to acute pancreatitis.The iatrogenic acute pancreatitis will influence the surgical strategy in patients scheduled for pancreaticoduodenectomy(PD).Due to the small number of cases,the surgical strategy in patients who require PD in the context of acute pancreatitis has not been standardized. | Sorin T Alexandrescu Andrei C Zlate Razvan T Grigorie Mihnea Ionescu Irinel Popescu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 1 |
| 10 | E-Alliance: A Negotiation Infrastructure for Virtual Alliances显示文摘 | Stefania Castellani Jean Marc Andreoli Mihnea Bratu Olivier Boissier Ilham Alloui Karim Megzari | 2003 | Group Decision and Negotiation2003，，2： | 1 |
| 11 | Role of Interleukin-28B Polymorphism as a Predictor of Sustained Virological Response in Patients with Chronic Hepatitis C Treated with Triple Therapy: A Systematic Review and Meta-Analysis显示文摘 | Simona Bota Ioan Sporea Roxana ?irli Adriana Maria Neghin? Alina Popescu Mihnea Str?in | 2013 | Clinical Drug Investigation2013，，5： | 1 |
| 12 | Resection for Hilar Cholangiocarcinoma: Analysis of Prognostic Factors and the Impact of Systemic Inflammation on Long-term Outcome显示文摘 | Traian Dumitrascu Dragos Chirita Mihnea Ionescu Irinel Popescu | 2013 | Journal of Gastrointestinal Surgery2013，，： | 1 |
| 13 | Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis显示文摘 | Traian Dumitrascu Simona Dima Vlad Herlea Victor Tomulescu Mihnea Ionescu Irinel Popescu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 1 |
| 14 | Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ显示文摘 | Christina R Mihnea V Michael P | 2002 | Biol Chem2002，277，46： | 1 |
| 15 | Towards the development of internet of things oriented robot to object interac-tion framework显示文摘 | Stanescu Aurelian Moisescu Mihnea Sacala Ioan | | 0，，： | 1 |
| 16 | Derivative complex, BGG correspondence, and?numerical inequalities for compact K?hler manifolds显示文摘 | Robert Lazarsfeld Mihnea Popa | 2010 | Inventiones mathematicae2010，，3： | 1 |
| 17 | 3D boron doped carbon nanorods/carbon- microfiber hybrid composites: synthesis and applications in a highly stable proton exchange membrane fuel cell 显示文摘 | Ioan(aIonescu Mihnea | 2011 | Joumal of Materials Chemistry2011，21，18： | 1 |
| 18 | Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ显示文摘 | Christina R Mihnea V Michael P | 2002 | Biol Chem2002，277，46： | 1 |
| 19 | Male gender and increased body mass index independently predicts clinically relevant morbidity after spleen-preserving distal pancreatectomy显示文摘AIM To identify risk factors for clinically relevant complications after spleen-preserving distal pancreatectomy(SPDP). No previous studies explored potential predictors of morbidity after SPDP.METHODS The data of 41 patients who underwent a SPDP in a single surgical center between 2000 and 2015 were retrospectively reviewed from a prospectively maintained electronic database established in our Department of Surgery. The database included demographic, clinical, bioumoral, pathological, intraoperative and postoperative parameters. Uni-and multivariate ana-lyses were performed to assess potential predictors of clinically relevant morbidity. Postoperative morbidity was defined as in-hospital complications and mortality was assessed at 90 d. Clinically relevant morbidity was defined as complication ≥ grade 2 Dindo.RESULTS Overall morbidity rate was 34.1%(14 patients): grade Ⅰ(6 patients, 14.6%), grade Ⅱ(2 patients, 4.8%), grade Ⅲa(1 patient, 2.4%), and grade Ⅲb(5 patients, 12.2%). A number of 5 patients(12.2%) required re-laparotomy for postoperative complications. There was no postoperative mortality. Thus, at least one clinically relevant complication occurred in 8 patients(19.5%). Univariate analysis identified male gender(P = 0.034), increased body mass index(P = 0.002) and neuroendocrine pathology(P = 0.013) as statistically significant risk factors. Multivariate analysis identified male gender [odds ratio(OR): 1.29, 95%CI: 1.07-1.55, P = 0.005] and increased body mass index(OR: 23.18, 95%CI: 1.72-310.96, P = 0.018) as the only independent risk factors of clinically relevant morbidity after SPDP.CONCLUSION Male gender and increased body mass index are independently associated with increased risk of clinically relevant morbidity after SPDP. These findings may assist a surgeon in clinical decision-making to better select patients suitable for SPDP. | Traian Dumitrascu Mihai Eftimie ANDra Aiordachioae Cezar Stroescu Simona Dima Mihnea Ionescu Irinel Popescu | 2018 | World Journal of Gastrointestinal Surgery2018，10，8： | 0 |
| 20 | Uncovering the dominant contribution of intermediate volatility compounds in secondary organic aerosol formation from biomass-burning emissions显示文摘Organic vapors from biomass burning are a major source of secondary organic aerosols(SOAs).Previous smog chamber studies found that the SOA contributors in biomass-burning emissions are mainly volatile organic compounds(VOCs).While intermediate volatility organic compounds(IVOCs)are efficient SOA precursors and contribute a considerable fraction of biomass-burning emissions,their contribution to SOA formation has not been directly observed.Here,by deploying a newly-developed oxidation flow reactor to study SOA formation from wood burning,we find that IVOCs can contribute ~70 %of the formed SOA,i.e.>2 times more than VOCs.This previously missing SOA fraction is interpreted to be due to the high wall losses of semi-volatile oxidation products of IVOCs in smog chambers.The finding in this study reveals that SOA production from biomass burning is much higher than previously thought,and highlights the urgent need for more research on the IVOCs from biomass burning and potentially other emission sources. | Kun Li Jun Zhang David M.Bell Tiantian Wang Houssni Lamkaddam Tianqu Cui Lu Qi Mihnea Surdu Dongyu Wang Lin Du Imad El Haddad Jay G.Slowik Andre S.H.Prevot | 2024 | National Science Review2024，11，3： | 0 |
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