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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study显示文摘 | Nauck Michael Frid Anders Hermansen Kjeld Shah Nalini S Tankova Tsvetalina Mitha Ismail H Zdravkovic Milan Düring Maria Matthews David R | 2009 | Diabetes Care2009，，： | 2 |
| 3 | Effect of loading parameters on the fatigue behavior of impact damaged composite laminates 显示文摘 | Milan M Hahn H T Greg P C | 1999 | Composites Science and Technology1999，59，14： | 1 |
| 4 | Influ- ence of UV-curing conditions on polymerization kinet- ics and gloss of urethane acrylate coatings显示文摘 | VIERA J MILAN M BOHUSLAVA H | 2013 | Progress in Organic Coatings2013，76，23： | 1 |
| 5 | Quinclorac resistance: a concerted hormonal and enzymatic effort in Echinochloa phyllopogon显示文摘 | Yasuor H Milan M Eckert J W | 2012 | Pest Manage Sci2012，68，1： | 1 |
| 6 | Saxagliptin:A New DPP-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus显示文摘 | Tahrani A A Milan K P Anthony H B | 2009 | Adv Ther2009，26，3： | 1 |
| 7 | High pressure and foodw-fiafit/vegetable juices显示文摘 | Milan H Jan S | 2006 | Journal of food engineering2006，77，3： | 1 |
| 8 | Reconstruction of the anterior cruciate ligament :dynamic strain evaluation of the graft 显示文摘 | Milan H Milan D Oiuliano C | 2007 | Knee Surg Sports Traumatol Arthrosc2007，8，： | 1 |
| 9 | Fuzzy Probabilistic optimization of building performance显示文摘 | Milan H | 1999 | Automation in Construction1999，8，： | 1 |
| 10 | Design-Oriented Analysis and Performance Evaluation of Buck PFC Front-end显示文摘 | Laszlo H Liu Gang Milan M J | | 0，，01： | 1 |
| 11 | Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS显示文摘 | Vít Herynek Kate?ina R??i?ková Pavla Jendelová Eva Syková Milan Hájek | 2009 | Magnetic Resonance Materials in Physics Biology and Medicine2009，，4： | 1 |
| 12 | Alcohol, tobacco and esophageal cancer: effects of the duration of consumption, mean intake and current and former consumption显示文摘 | LAUNOY G MILAN C H FAIVRE J | 1997 | Br J Cancer1997，75，9： | 1 |
| 13 | Synthesis, electrochemistry, and single-molecule conductance of bi- metallic 2,3,5,6-tetra(pyridine-2-yl) pyrazine-based complexes显示文摘 | Davidson R Liang J H Milan D C | 2015 | Inorg Chem2015，54，： | 1 |
| 14 | Dynamics of seed imbibition and germination of Austrian pine (Pinus nigra Arnold) from extreme habitat conditions within five Balkan provenances 显示文摘 | Milan M Diane L H Vasilije I | 2010 | New Forests2010，40，： | 1 |
| 15 | Matrix metalloproteinase -9 and Tisse inhibitor of metalloproteinases - 1 in Acute pyelonephritis and renal scarring显示文摘 | Milan Chromek Kjell T 01of H | 2003 | Pdiatric Research2003，53，4： | 1 |
| 16 | Material flow accounts, balancesand derived in dictators for the Czech Republicduring the 1990s:results and recommendations formethodological improvements显示文摘 | Milan S Jan K Tomas H | 2003 | Ecological Eeonomics2003，45，1： | 1 |
| 17 | High pressure and foods-fruit/vegetable juices显示文摘 | Milan H Jan S Katerina K | 2006 | Journal of Food Engineering2006，77，： | 1 |
| 18 | Reconstruction of the anterior cruciate ligament dynamic strain evaluation of the graft显示文摘 | Milan H Milan D Giuliano C | 2007 | Knee Surg Sports Traumatol Arthrosc2007，15，8： | 1 |
| 19 | The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome显示文摘 | Escobar-Morreale H F Luque-Ramirez M San Milan J L | 2005 | Endocr Rev2005，26，2： | 1 |
| 20 | Intergranular Corrosion of AISI 316L Steel显示文摘 | Martin M Ludmila H Milan S | 2001 | Materials Character- ization2001，46，2： | 1 |
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