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| 1 | Primary colorectal lymphoma:An overview显示文摘Lymphomas represent common hematological malignancies with increasing incidence in recent years.The major site of extranodal non-Hodgkin lymphoma is the gastrointestinal tract.Involvement of the large intestine is rare in comparison to the stomach or small bowel.The disease appears later in life,predominantly in the male population.Complaints are nonspecific,requiring a high index of suspicion in order to establish the diagnosis.The treatment varies from chemotherapy alone to multimodal therapies combining surgery,chemotherapy and radiotherapy.The small number of patients with various histological subtypes and different stage at presentation results in unclear protocol for the treatment of primary colorectal lymphoma.The purpose of this paper is to review current data on primary lymphoma of the colon and rectum while analyzing reported case series and published material on the subject. | Goran Z Stanojevic Milica D Nestorovic Branko R Brankovic Miroslav P Stojanovic Milan M Jovanovic Milan D Radojkovic | 2011 | World Journal of Gastrointestinal Oncology2011，3，1： | 15 |
| 2 | Comparison of two nutritional assessment methods in gastroenterology patients显示文摘AIM:To investigate and compare efficacy and differences in the nutritional status evaluation of gastroenterology patients by application of two methods:subjective global assessment(SGA) and nutritional risk index(NRI).METHODS:The investigation was performed on 299 hospitalized patients,aged 18-84 years(average life span 55.57 ± 12.84),with different gastrointe-stinal pathology,admitted to the Department of Gastroenterohepatology,Clinical and Hospital Center 'Bezanijska Kosa' during a period of 180 d.All the patients,after being informed in detail about the study and signing a written consent,underwent nutritional status analysis,which included two different nutritional indices:SGA and NRI,anthropometric parameters,bioelectrical impedance analysis,and biochemical markers,within 24 h of admission.RESULTS:In our sample of 299 hospitalized patients,global malnutrition prevalence upon admission varied from 45.7% as assessed by the SGA to 63.9% by NRI.Two applied methods required different parameters for an adequate approach:glucose level(5.68 ± 1.06 mmol/L vs 4.83 ± 1.14 mmol/L,F = 10.63,P = 0.001);body mass index(26.03 ± 4.53 kg/m2 vs 18.17 ± 1.52 kg/m2,F = 58.36,P < 0.001);total body water(42.62 ± 7.98 kg vs 36.22 ± 9.32 kg,F = 7.95,P = 0.005);basal metabolic rate(1625.14 ± 304.91 kcal vs 1344.62 ± 219.08 kcal,F = 9.06,P = 0.003) were very important for SGA,and lymphocyte count was relevant for NRI:25.56% ± 8.94% vs 21.77% ± 10.08%,F = 11.55,P = 0.001.The number of malnourished patients rose with the length of hospital stay according to both nutritional indices.The discriminative function analysis(DFA) delineated the following parameters as important for prediction of nutritional status according to SGA assessment:concentration of albumins,level of proteins,SGA score and body weight.The DFA extracted MAMC,glucose level and NRI scores were variables of importance for the prediction of whether admitted patients would be classif ied as well or malnourished.CONCLUSION:SGA showed higher sensitivity to predictor factors.Assessment of nutritional status requires a multidimensional approach,which includes different clinical indices and various nutritional param eters. | Branka F Filipovi Milan Gaji Nikola Milini Branislav Milovanovi Branislav R Filipovi Mirjana Cvetkovi Nela ibali | 2010 | World Journal of Gastroenterology2010，16，16： | 9 |
| 3 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 4 | Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study显示文摘 | Nauck Michael Frid Anders Hermansen Kjeld Shah Nalini S Tankova Tsvetalina Mitha Ismail H Zdravkovic Milan Düring Maria Matthews David R | 2009 | Diabetes Care2009，，： | 2 |
| 5 | Antibiotic selective pressure and development of bacterial resistance 显示文摘 | Milan Kola′r Karel Urba′nek Toma′sv La′tal | 2001 | International Journal of Antimicrobial Agents2001，17，： | 1 |
| 6 | Assessment of the ^137Cs method for estimating sediment accumulation rates:Louisiana salt marshes显示文摘 | Milan C S Swenson E M Turner R E | 1995 | Journal of Coastal Research1995，11，2： | 1 |
| 7 | Modification of cervical dystonia by sel-tive sen sory stimulation显示文摘 | Leis A Milan R | 2007 | Journal of Neurologucal Science2007，103，110： | 1 |
| 8 | Multiple signaling pathways are involved in endothelin-l-induced brain endothelial Cell migration显示文摘 | Milan J Chaxalambous C Elhag R | 2006 | Am J Physiol cell physiol2006，291，1： | 1 |
| 9 | The optimization of the extrusion process when u-sing maize flour with a modified amino acid profile for mak-ing tortillas 显示文摘 | Milan Carrillo J Gutierrez Dorado R Perales Sanchez J XK | 2006 | International Journal of Food Science &Technology2006，41，7： | 1 |
| 10 | Asynchronous BCI and Local Neural Classifiers 显示文摘 | Milan J R Mourino J | 2003 | IEEE Transactions on Neural Systems and Rehabilitation Engineering2003，11，2： | 1 |
| 11 | Review article: adipocytokines and insulin resistance 显示文摘 | Vettor R Milan G Rossata M | 2005 | Aliment Pharmacol Ther2005，22，2： | 1 |
| 12 | Contribution of potassium in human plaeental steroidogenesis显示文摘 | Milan R Flores-Herrera O Espinosa-Garcia MT | 2010 | Placenta2010，31，10： | 1 |
| 13 | Automatic lateral control for unmanned vehicles via genetic algorithms 显示文摘 | ONIEVA E NARANJO J E MILANES V ALONSO J GARCIA R PEREZ J | 2011 | Applied Soft Computing Journal2011，11，1： | 1 |
| 14 | Quantitative real-time PCR study on persistence of pDNA vaccine pVax-Hsp60TM814 in beef muscles 显示文摘 | Petr O Veronika K Milan R | 2008 | Genet Vaccine Ther2008，6，： | 1 |
| 15 | Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD显示文摘 | AI - Shair K Dockry R Mallia - Milanes B | 2009 | Respir Med2009，103，10： | 1 |
| 16 | The making of successful axonal regeneration genes,molecules and signal transduction pathways显示文摘 | Gennadij R Milan M | 2007 | Brain Research Reviews2007，53，2： | 1 |
| 17 | Smad2 and 3 tran- scription factors control muscle mass in adulthood显示文摘 | Sartori R Milan G Patron M | 2009 | Am J Physiol Cell Physiol2009，296，： | 1 |
| 18 | CpG DNA can induce strong Thl humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice显示文摘 | Brazolot Milan CL Weeratna R Krieg AM | 1998 | Proc Natl Aead Sci USA1998，95，15： | 1 |
| 19 | Assessment of the ^137 Cs method for estimating sediment accumulation rates: Louisiana salt marshes显示文摘 | Milan C S Swenson E M Turner R E | 1995 | Journal of Coastal Research1995，11，2： | 1 |
| 20 | Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS显示文摘 | Vít Herynek Kate?ina R??i?ková Pavla Jendelová Eva Syková Milan Hájek | 2009 | Magnetic Resonance Materials in Physics Biology and Medicine2009，，4： | 1 |
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