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| 1 | Characteristics and efficacy of modified adenomyomectomy in the treatment of uterine adenomyoma显示文摘背景 Adenomyoma 是影响生活的质量的很严重的疾病并且在结束导致不孕,和子宫切除。Unfortunetly,我们仍然没有有效方法治疗这种疾病。这研究被瞄准评估功效和这是的修改 adenomyomectomy.Methods 的外科的特征回顾的研究和这些题目在过去的 5 年里被收集。我们由二个不同外科的过程划分了这些题目。经历了保守外科,修改 adenomyomectomy 或 adenomyoma 损害的楔切除术的 adenomyoma 病人的盒子被散布到二个组 retrospectively.Surgical 特征,症状消除,和复发在每个 group.Results 将军特征被分析,包括操作时间,血损失,和手术后的复杂并发症在两个组是类似的。在修改 adenomyometomy 组,中部的后续时间是 27.6 个月和痛经的地势的率, menorrhagia 症状分别地是 91.2% 和 40.0% 。在楔切除术组,痛经和 menorrhagia 症状的 reliefe 的率分别地是 88.9% 和 50.0% 。在两个组的病人有统计上重要的症状地势,但是他们之间没有统计差别。在下列时间期间,在修改修改 adenomyomectomy 组的 ultrasonography 恶化率比楔切除术组显著地低 15.0% 对 69.2%(P 0.001 ) 。以症状,恶化率在修改 adenomyomectomy 组是 5.0% ,它类似于在楔切除术组的恶化率。以繁殖结果,有在修改 adenomyomectomy 组的不孕复杂并发症的33.3%病人成为了 pregnant.Among 他们,由帮助繁殖技术的怀孕的率是45.5%,它比自然怀孕的率显著地高,23.1%( P=0.039 ) .Conclusion 修改了 adenomyomectomy 看起来是一只保险箱和在在外科以后减少恶化的率显示出优点的有效起作用的方法。 | SUN Ai-jun LUO Min WANG Wei CHEN Rong LANG Jing-he | 2011 | Chinese Medical Journal2011，，9： | 15 |
| 2 | Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China显示文摘 | Hua Yang Xiao-Chuan Li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan Li Jian-Hua Zheng Man-Hua Cui Huai-Fang Li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing Liu Ya-Li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang Li-Na Hu Mu-Jun Li Hong-Lin Zhou Jing-Hui Song Lan Zhu | 2017 | Chinese Medical Journal2017，，22： | 10 |
| 3 | Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia显示文摘AIM: To explore the correlation between Helicobacter pylori(H. pylori)-associated gastric diseases and colorectal neoplasia.METHODS: Patients included in this study underwent a colonoscopy and esophago-gastro-duodenoscopy(EGD) along with histopathological measurement between March 2012 and March 2015 at Qi-Lu Hospital of Shandong University, who also had results of H. pylori detection. A total of 233 cases were selected. Demographic data, H. pylori infection status(including results of rapid urease tests and gastric mucosa pathological examinations) and histopathological examination results of gastric and colorectal mucosa were gathered and analyzed. The statistical analysis focused on the prevalence of colorectal neoplasms among patients with various histopathological categories of the stomach. ORs and their 95%CI were calculated to describe the strengths of the associations.RESULTS: The incidence rates of colorectal adenoma without high-grade intraepithelial neoplasia(HGIEN)(OR = 2.400, 95%CI: 0.969-5.941), adenoma with HGIEN(5.333, 1.025-27.758) and adenocarcinoma(1.455, 0.382-5.543) were all higher for patients with H. pylori-associated gastritis than for those in the control group. The incidence rate of colorectal adenoma with HGIEN(3.218, 0.767-13.509) was higher in patients with intestinal metaplasia than in the control group, while the incidence rates of adenoma without HGIEN(0.874, 0.414-1.845) and adenocarcinoma(0.376, 0.096-1.470) were lower in the intestinal metaplasia group than in the control group. The incidence rate of colorectal adenoma without HGIEN(3.111, 1.248-7.753) was significantly higher in the gastric intraepithelial neoplasia group than in the control group, while the rates of adenoma with HGIEN(1.481, 0.138-15.941) and adenocarcinoma(2.020, 0.561-7.272) were higher in the gastric intraepithelial neoplasia group. Incidence rates of colorectal adenoma without HGIEN(1.067, 0.264-4.314), adenoma with HGIEN(2.667, 0.231-30.800) and adenocarcinoma(2.182, 0.450-10.585) were all higher in the gastric adenocarcinoma group than in the control group.CONCLUSION: H. pylori infection as well as H. pylori-associated gastric diseases are risk factors for colorectal neoplasia. | Ying Qing Min Wang Ying-Min Lin Dong Wu Jing-Yu Zhu Lang Gao Yan-Yan Liu Teng-Fei Yin | 2016 | World Journal of Gastroenterology2016，22，18： | 8 |
| 4 | Heteroclitins R-S: new dibenzocylooctadiene lignans from Kadsura heteroclita显示文摘AIM: To study the dibenzocylooctadiene lignans from the stems of Kadsura heteroclita. METHOD: Chromatographic separations of silica gel and semi-preparative HPLC were used. All of the structures were elucidated on the basis of spectroscopic analysis,including 2D-NMR and HR-MS techniques. RESULTS: Four dibenzocylooctadiene lignans were isolated from K. heteroclita. Their structures were identified as heteroclitin R(1), heteroclitin S(2), gonisin O(3), and schisanlignone A(4). CONCLUSION: Heteroclitin R(1) and heteroclitin S(2) are new natural lignans. | CHEN Min LUO You-Ping ZOU Yan-Lin LANG Ling-Hu CHEN Dao-Feng | 2014 | Chinese Journal of Natural Medicines2014，12，9： | 8 |
| 5 | Preparation and application of monoclonal antibodies against hepatitis C virus nonstructural proteins显示文摘PreparationandapplicationofmonoclonalantibodiesagainsthepatitisCvirusnonstructuralproteinsGAOJianEn,TAOQiMin,GUOJianPin... | GAO Jian En, TAO Qi Min, GUO Jian Ping, JI He Ping, LANG Zheng Wei, JI Ying and FENG Bai Fang | 1997 | World Journal of Gastroenterology1997，3，2： | 6 |
| 6 | Five-year results of refractive outcomes and visionrelated quality of life after SMILE for the correction of high myopia显示文摘AIM:To evaluate the long-term visual,refractive outcomes and vision-related quality of life after small incision lenticule extraction(SMILE)for the correction of high myopia.METHODS:Thirty patients(60 eyes)with high myopia who underwent SMILE more than 5y were selected as the SMILE group.Another 30 high myopia patients(60 eyes)who had worn corrective spectacles for more than 5y were selected as the control group.In SMILE group,the postoperative follow-up time were 3,6 mo,1 and 5y.Uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),spherical equivalent(SE),and ocular axial length(AL)were analyzed.The Chinese version of the National Eye Institute Visual Function Questionnaire-25(CHI-NEI-VFQ-25)was used to evaluate the vision-related quality of life in the SMILE group and the control group.RESULTS:In SMILE group,the mean preoperative SE was-7.29±0.87 D(range-6.00 to-9.125 D).At 5-year follow up,the efficacy index and safety index of SMILE were 1.09±0.18 and 1.19±0.12,respectively.Five years postoperatively,44 eyes(73%)obtained a visual acuity of 20/20 or better.There were no eyes with CDVA loss of one or more Snellen lines.Forty-nine eyes(82%)and 57 eyes(95%)were within±0.50 and±1.00 D of attempted correction at 5-year follow-up,respectively.Forty-eight eyes(80%)had astigmatism<0.50 D at 5-year followup.The postoperative mean SE values at 3,6 mo,1,and 5y were 0.11±0.44,0.07±0.45,-0.02±0.41,and-0.15±0.46 D,respectively.No significant change was observed in the ocular AL from before operation to 5y postoperatively(26.08±0.96 mm vs 26.01±0.94 mm,P=0.068).Compared to the control group,the SMILE group showed a significantly higher total score on the CHI-NEI-VFQ-25(90.14 vs 81.43,P<0.001).CONCLUSION:In the present study,in a long-term follow-up we demonstrate that correcting high myopia with SMILE is safe,effective,and predictable.Vision-related quality of life after SMILE is better in the SMILE group than in the control group who wore corrective spectacles. | Min Lang Kai-Wei Cao Ting Liu Ying Zhu Jian Ye | 2021 | International Journal of Ophthalmology(English edition)2021，14，9： | 4 |
| 7 | The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids显示文摘Magnolia biondii Pamp.(Magnoliaceae,magnoliids)is a phylogenetically,economically,and medicinally important ornamental tree species widely grown and cultivated in the north-temperate regions of China.Determining the genome sequence of M.biondii would help resolve the phylogenetic uncertainty of magnoliids and improve the understanding of individual trait evolution within the Magnolia genus.We assembled a chromosome-level reference genome of M.biondii using~67,~175,and~154Gb of raw DNA sequences generated via Pacific Biosciences single-molecule real-time sequencing,10X Genomics Chromium,and Hi-C scaffolding strategies,respectively.The final genome assembly was~2.22Gb,with a contig N50 value of 269.11 kb and a BUSCO complete gene percentage of 91.90%.Approximately 89.17%of the genome was organized into 19 chromosomes,resulting in a scaffold N50 of 92.86Mb.The genome contained 47,547 protein-coding genes,accounting for 23.47%of the genome length,whereas 66.48%of the genome length consisted of repetitive elements.We confirmed a WGD event that occurred very close to the time of the split between the Magnoliales and Laurales.Functional enrichment of the Magnolia-specific and expanded gene families highlighted genes involved in the biosynthesis of secondary metabolites,plant–pathogen interactions,and responses to stimuli,which may improve the ecological fitness and biological adaptability of the lineage.Phylogenomic analyses revealed a sister relationship of magnoliids and Chloranthaceae,which are sister to a clade comprising monocots and eudicots.The genome sequence of M.biondii could lead to trait improvement,germplasm conservation,and evolutionary studies on the rapid radiation of early angiosperms. | Shanshan Dong Min Liu Yang Liu Fei Chen Ting Yang Lu Chen Xingtan Zhang Xing Guo Dongming Fang Linzhou Li Tian Deng Zhangxiu Yao Xiaoan Lang Yiqing Gong Ernest Wu Yaling Wang Yamei Shen Xun Gong Huan Liu Shouzhou Zhang | 2021 | Horticulture Research2021，8，1： | 4 |
| 8 | In situ fluorinated solid electrolyte interphase towards long-life lithium metal anodes显示文摘The urgent demands for high-energy-density rechargeable batteries promote a flourishing development of Li metal anode.However,the uncontrollable dendrites growth and serious side reactions severely lirmit its commercial application.Herein,an artificial LiF-rich solid electrolyte interphase(SEl)is constructed at molecular-level using one-step photopolymerization of hexafluorobutyl acrylate based solution,where the LiF is in situ generated during photopolymerization process(denoted as PHALF).The LiF-rich layercomprised flexible polymer matrix and inorganic LiF filler not only ensures intimate contact with Li anode and adapts volume fluctuations during cycling but also regulates Li deposition behavior,enabling it to suppress the dendrite growth and block side reactions between the electrolyte and Li metal.Accordingly,the PHALF-Li anode presents superior stable cycling performance over 500 h at 1 mA·cm^-2 for 1 mA·h·cm^-2 without dendrites growth in carbonate electrolyte.The work provides a novel approach to design and build in situ artificial SEl layer for high-safety and stable Li metal anodes. | Shan-Min Xu Hui Duan Ji-Lei Shi Tong-Tong Zuo Xin-Cheng Hu Shuang-Yan Lang Min Yan Jia-Yan Liang Yu-Guo Yang Qing-Hua Kong Xing Zhang Yu-Guo Guo | 2020 | Nano Research2020，13，2： | 3 |
| 9 | Developing transgenic maize(Zea mays L.) with insect resistance and glyphosate tolerance by fusion gene transformation显示文摘Using linker peptide LP4/2A for multiple gene transformation is considered to be an effective method to stack or pyramid several traits in plants. Bacillus thuringiensis(Bt) cry gene and epsps(5-enolpyruvylshikimate-3-phosphate synthase) gene are two important genes for culturing pest-resistant and glyphosate-tolerant crops. We used linker peptide LP4/2A to connect the Bt cry1 Ah gene with the 2m G2-epsps gene and combined the wide-used man A gene as a selective marker to construct one coordinated expression vector called p2 EPUHLAGN. The expression vector was transferred into maize by Agrobacterium tumefaciens-mediated transformation, and 60 plants were obtained, 40% of which were positive transformants. Molecular detection demonstrated that the two genes in the fusion vector were expressed simultaneously and spliced correctly in translation processing; meanwhile bioassay detection proved the transgenic maize had preferable pest resistance and glyphosate tolerance. Therefore, linker peptide LP4/2A provided a simple and reliable strategy for producing gene stacking in maize and the result showed that the fusion gene transformation system of LP4/2A was feasible in monocot plants. | SUN He LANG Zhi-hong LU Wei ZHANG Jie HE Kang-lai ZHU Li LIN Min HUANG Da-fang | 2015 | Journal of Integrative Agriculture2015，14，2： | 2 |
| 10 | Electrochemical behavior and underpotential deposition of Sm on reactive electrodes(Al,Ni,Cu and Zn)in a LiCl-KCl melt显示文摘Sm extraction from a LiCl-KCl melt was carried out by forming alloys on various electrodes,including Al,Ni,Cu,and liquid Zn,and the electrochemical behaviors of the resultant metal products were investigated using different electrochemical techniques.While Sm metal deposition via the conventional two-step reaction process was not noted on the inert electrode,underpotential deposition was observed on the reactive electrodes because of the latter's depolarization effect.The depolarization effects of the reactive electrodes on Sm showed the order Zn>Al>Ni>Cu.Sm-M(M=Al,Ni,Cu,Zn)alloys were deposited by galvanostatic and potentiostatic electrolysis.The products were fully characterized by X-ray diffractometry(XRD)and scanning electron microscopy(SEM)-energy dispersive spectrometry(EDS),and the stability of the obtained M-rich compounds was determined.Finally,the relationship between the electrode potential and type of Sm-M intermetallic compounds formed was assessed on the basis of the observed electrochemical properties and electrodeposits. | Tai-qi Yin Lang Chen Yun Xue Yang-hai Zheng Xue-peng Wang Yong-de Yan Mi-lin Zhang Gui-ling Wang Fan Gao Min Qiu | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，12： | 2 |
| 11 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 12 | Pilot-assisted wireless transmissions: general model, design criteria, and signal proeessing显示文摘 | Lang T Sadler B M Min Dong | 2004 | IEEE Signal Processing Magazine2004，21，6： | 1 |
| 13 | Cationic poly(?-caprolactone) surface functionalized mesoporous silica nanoparticles and their application in drug delivery显示文摘 | Yan Zhang Zhaojun Wang Weimin Zhou Guoquan Min Meidong Lang | 2013 | Applied Surface Science2013，，： | 1 |
| 14 | In vitro antioxidant activities of low-molecular-weight polysaccharides with various functional groups显示文摘 | Szu Kai Chen Min Lang Tsai Jin Ru Huang | 2009 | Agricultural and Food Chemistry2009，57，： | 1 |
| 15 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 16 | Plastid and nuclear phylogenomic incongruences and biogeographic implications of Magnolia s.l.(Magnoliaceae)显示文摘Magnoliaceae,an assemblage of early diverged angiosperms,comprises two subfamilies,speciose Magnolioideae with approximately 300 species in varying numbers of genera and monogeneric Liriodendroideae with two species in Liriodendron L.This family occupies a pivotal phylogenetic position with important insights into the diversification of early angiosperms,and shows intercontinentally disjunct distribution patterns between eastern Asia and the Americas.Widespread morphological homogeneity and slow substitution rates in Magnolia L.s.l.resulted in poorly supported phylogenetic relationships based on morphology or molecular evidence,which hampers our understanding of the genus,temporal and spacial evolution.Here,based on the newly generated genome skimming data for 48 Magno/fa s.l.species,we produced robust/Vlagno/kj phylogenies using genome-wide markers from both plastid genomes and single nucleotide polymorphism data.Contrasting the plastid and nuclear phylogenies revealed extensive cytonuclear conflicts in both shallow and deep relationships.ABBA-BABA and PhyloNet analyses suggested hybridization occurred within sect.Yulania,and sect.Magnolia,which is in concordance with the ploidy level of the species in these two sections.Divergence time estimates and biogeographic reconstruction indicated that the timing of the three tropical Magnolia disjunctions coincided with the mid-Eocene cooling climate and/or late Eocene climate deterioration,and two temperate disjunctions occurred much later,possibly during the warm periods of the Miocene,hence supporting the boreotropical flora concept of Magnolia s.l. | Shan-Shan Dong Ya-Ling Wang Nian-He Xia Yang Liu Min Liu Lian Lian Na Li Ling-Fei Li Xiao-An Lang Yi-Qing Gong Lu Chen Ernest Wu Shou-Zhou Zhang | 2022 | Journal of Systematics and Evolution2022，60，1： | 1 |
| 17 | Programming of Regulatory T Cells In Situ for Nerve Regeneration and Long-Term Patency of Vascular Grafts显示文摘Rapid integration into the host tissue is critical for long-term patency after small diameter tissue engineering vascular grafts(sdTEVGs)transplantation.Neural recognition may be required for host integration and functionalization of the graft.However,immune rejection and inflammation hinder nerve regeneration of sdTEVGs.Here,a CRISPR/dCas9-nanocarrier was used for targeted programming of regulatory T cells(Treg cells)in situ to promote nerve regeneration of sdTEVGs by preventing excessive inflammation.Treg cells and(C-C chemokine receptor)CCR2+macrophage recruitment occurred after transplantation.The nanodelivery system upregulated ten eleven translocation(TET2)in Treg cells in vitro.Reprogrammed Treg cells upregulated anti-inflammatory cytokines and decreased the proportion of CCR2+macrophages.IL-6 concentrations decreased to the levels required for nerve regeneration.Implantation of CRISPR/dCas9 nanodelivery system-modified sdTEVGs in rats resulted in Treg cell editing,control of excessive inflammation,and promoted nerve regeneration.After 3 months,nerve regeneration was similar to that observed in normal blood vessels;good immune homeostasis,consistency of hemodynamics,and matrix regeneration were observed.Neural recognition promotes further integration of the graft into the host,with unobstructed blood vessels without intimal hyperplasia.Our findings provide new insights into vascular implant functionalization by the host. | Yanhong Wang Fangchao Xue Yanzhao Li Lin Lin Yeqin Wang Shanlan Zhao Xingli Zhao Yong Liu Ju Tan Gang Li Haoran Xiao Juan Yan Hao Tian Min Liu Qiao Zhang Zhaojing Ba Lang He Wenyan Zhao Chuhong Zhu Wen Zeng | 2022 | Research2022，，4： | 1 |
| 18 | Two - stage microfluidization combined with ultrafiltration treatment for chitosan mass production and molecular weight manipula- tion 显示文摘 | Min Lang Tsai Lan Zang Tseng Rong Huei Cheng | 2009 | Carbohydrate Polymers2009，77，4： | 1 |
| 19 | Changes in the Mark–Houwink hydrodynamic volume of chitosan molecules in solutions of different organic acids, at different temperatures and ionic strengths显示文摘 | Rong Huei Chen Wei Yu Chen Shang Ta Wang Chu Hsi Hsu Min Lang Tsai | 2009 | Carbohydrate Polymers2009，，4： | 1 |
| 20 | THE EARLY EFFECT OF PELVIC FLOOR MUSCLE EXERCISE AFTER TRANSURETHRAL PROSTATECTOMY显示文摘 | PHEI LANG CHANG LI HUNY TSAI SHIH TSUNG HUANG TA MIN WANG MING LI HSIEH KE HUNG TSUI | 1998 | The Journal of Urology1998，，2： | 1 |
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