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| 1 | LATERAL ORGAN BOUNDARIES DOMAIN transcription factors direct callus formation in Arabidopsis regeneration显示文摘在文化条件下面的植物纸巾或机关的显著新生能力有 underlain 为十年的一个广泛的惯例。在在 vitro 新生的植物的起始的步经常包含一个 pluripotent 房间团的正式就职称为的胼胝,它被植物激素植物生长素驾驶并且经由一条根发展小径发生。然而,管理胼胝形成的关键分子仍然保持未知。这里,我们证明 Arabidopsis 侧面的机关边界域(LBD )/ASYMMETRIC 象 LEAVES2 一样(ASL ) 抄写因素涉及胼胝形成节目的控制。植物生长素反应因素(ARF ) 下游的四 LBD 基因, LBD16, LBD17, LBD18 和 LBD29,被导致胼胝的媒介(计算机输入缩微胶卷) 很快并且戏剧性地在多重机关导致。每在 Arabidopsis 的四 LBD 基因的宫外的表示是足够的没有外长的植物激素,触发自发的胼胝形成,而 LBD 功能的抑制禁止计算机输入缩微胶卷导致的胼胝形成。而且, LBD 触发的胼胝类似于由宫外地激活的根分裂组织基因和有效新生能力的特征由计算机输入缩微胶卷导致了那。这些调查结果在胼胝正式就职进程把 LBD 抄写因素定义为关键管理者,从而建立在发信号的植物生长素和植物新生程序之间的一个分子的连接。 | Mingzhu Fan Chongyi Xu Ke Xu Yuxin Hu | 2012 | Cell Research2012，22，7： | 42 |
| 2 | SHRIMP zircon U-Pb dating of late Paleoproterozoic kondalites in the Daqing Mountains area on the North China Craton显示文摘The Daqing Mountains area comprises a typical occurrence of the Khondalite Belt in the Western Block of the North China Craton (NCC). In this area, both early and late Paleoproterozoic metasedimentary rocks have been identified in what was originally called the Upper Wula Mountains 'Subgroup'. Six metasedimentary rock samples yielded SHRIMP U-Pb zircon ages of 2.56-2.04 Ga for detrital and 1.96-1.83 Ga for metamorphic zircons. Based on these data and previously published results, the following conclusions can be drawn: 1) The source region for the late Paleoproterozoic detrital sedimentary rocks is mainly 2.55 2.4 and 2.2 2.04 Ga in age, consistent with the early Precambrian geological history identified widely in the basement of the NCC. 2) The majority of sedimentary rocks of the khondalite series were deposited between 2.04 and 1.95 Ga, and then in a protracted period (1.96 and 1.83 Ga) underwent a complex history of amphibolite to granulite-facies metamorphism. | DONG ChunYan WAN YuSheng XU ZhongYuan LIU DunYi YANG ZhenSheng MA MingZhu XIE HangQiang | 2013 | Science China Earth Sciences2013，56，1： | 43 |
| 3 | Spatial and temporal variations of forest LAI in China during 2000-2010显示文摘Forests are crucial terrestrial ecosystems.Their leaf area index (LAI) is a key parameter determining the exchange of matter and energy between the atmosphere and the ground surface.In this study,MOD 09A1 and MCD 43A1 data were input into an inversion model based on the 4-scale geometric optical model to retrieve 8-d 500 m LAI products in China during the period 2000 to 2010.The resulting LAI product was validated using LAI measured in 6 typical areas.The spatial and temporal variations of forest LAI and its relationships with temperature and precipitation were analyzed.The results show that the accuracy of the 500 m LAI product was above 70% in the 6 typical areas,indicating the reliability of this product.From 2000 to 2010,forest LAI in northeast,north,and south central China showed increasing trends.However,forest LAI in southeast and parts of southwest China showed downward trends,mainly because of the significant decrease observed during the period 2008 to 2010.Annual mean forest LAI positively correlated with annual mean temperature (AMT) in northeastern China and negatively correlated with AMT in southwest China.It had positive correlations with annual total precipitation in central south and north China.The abnormal climate conditions in 2001 and 2009 caused forest LAI to be obviously lower than normal in regions south of the Qinling Mountains and Huaihe River.Annual mean LAI decreased by more than 1.0 in some areas. | LIU YiBo JU WeiMin CHEN JingMing ZHU GaoLong XING BaiLing ZHU JingFang HE MingZhu | 2012 | Chinese Science Bulletin2012，57，22： | 22 |
| 4 | Patterns of shrub species richness and abundance in relation to environmental factors on the Alxa Plateau:Prerequisites for conserving shrub diversity in extreme arid desert regions显示文摘Shrub species are considered the dominant plants in arid desert ecosystems,unlike in semiarid steppe zones or in grassland ecosystems.On the Alxa Plateau,northern China,sparse vegetation with cover ranging from 15% to 30% is characterized mainly by multifarious shrubs because herbaceous species are strongly restricted by the extreme drought climate,wind erosion,overgrazing and sand burial.Patterns in shrub species richness and species abundance in relation to environmental conditions were examined by DCA(detrended correspondence analysis) and interpreted by a biplot.The rela-tionships between species diversity and environmental factors were examined using regression analyses.Our results show that the distributions of the shrub species in response to environmental conditions can be grouped into four ecological types,corresponding with the biological traits of the shrubs and their responses to the gradients of soil texture and soil water content.Patterns in species richness and species abundance were mainly determined by the deeper soil water content,instead of the soil texture as hypothesized by numerous studies in semiarid grasslands.With exception of the deeper soil water content,soil organic matter and total N content were positively correlated with species abundance,while pH was negatively correlated with it.These findings imply that it is vital for cur-rent shrub diversity conservation to reduce agricultural water use in the middle reaches of the Heihe River,which supplies water for the lower reaches in the western parts of the plateau,and to reduce the amount of groundwater exploitation and urban and oasis water use,to increase the water supply from Helan Mountain to the eastern desert of the Alxa Plateau. | XinRong Li HuiJuan Tan MingZhu He XinPing Wang XiaoJun Li | 2009 | Science China Earth Sciences2009，52，5： | 17 |
| 5 | Variety distribution pattern and climatic potential productivity of spring maize in Northeast China under climate change显示文摘This study was based on the daily meteorological data of 101 meteorological stations from 1971 to 2000 and the 0.25°×0.25° grid data from 1951 to 2100 simulated by RegCM3 under the future A1B climatic scenario published by National Climate Center,in combination with the demand of climatic condition for maize growth in Northeast China.The trajectory of agricultural climatic resources and the effects of climate change on variety distribution and climatic potential productivity of spring maize in Northeast China under future climate change were analyzed.The main agro-climatic resource factors include:the initial date daily average temperature stably passing 10℃(≥10℃),the first frost date,the days of growing period,the ≥10℃ accumulated temperature,and the total radiation and precipitation in the growing period.The results showed that:(1) in the coming 100 years,the first date of ≥10℃ would be significantly advanced,and the first frost date would be delayed.The days of growing period would be extended,the ≥10℃ accumulated temperature and the total radiation would be significantly increased.However,no significant change was found in precipitation.(2) Due to the climate change,the early-maturing varieties will be gradually replaced by late-maturing varieties in Northeast China,and the planting boundaries of several maize varieties would be extended northward and eastward.(3) There would be a significant change in the climatic potential productivity of maize in Northeast China with the high-value gradually moving towards northeast.(4) It was an effective way to increase the climatic potential productivity of maize by appropriate adjustment of sowing date. | YUAN Bin GUO JlanPing YE MingZhu ZHAO JunFang | 2012 | Chinese Science Bulletin2012，57，26： | 16 |
| 6 | Bioactive hydrogels for bone regeneration显示文摘Bone self-healing is limited and generally requires external intervention to augment bone repair and regeneration.While traditional methods for repairing bone defects such as autografts,allografts,and xenografts have been widely used,they all have corresponding disadvantages,thus limiting their clinical use.Despite the development of a variety of biomaterials,including metal implants,calcium phosphate cements(CPC),hydroxyapatite,etc.,the desired therapeutic effect is not fully achieved.Currently,polymeric scaffolds,particularly hydrogels,are of interest and their unique configurations and tunable physicochemical properties have been extensively studied.This review will focus on the applications of various cutting-edge bioactive hydrogels systems in bone regeneration,as well as their advantages and limitations.We will examine the composition and defects of the bone,discuss the current biomaterials for bone regeneration,and classify recently developed polymeric materials for hydrogel synthesis.We will also elaborate on the properties of desirable hydrogels as well as the fabrication techniques and different delivery strategies.Finally,the existing challenges,considerations,and the future prospective of hydrogels in bone regeneration will be outlined. | Xin Bai Mingzhu Gao Sahla Syed Jerry Zhuang Xiaoyang Xu Xue-Qing Zhang | 2018 | Bioactive Materials2018，3，4： | 15 |
| 7 | WRITING ENGLISH THE ENGLISH WAY——A STUDY OF THE CAUSES OF CHINGLISH显示文摘The linguistic interference of one’s mother tonguealways poses an obstacle to his or her learning of for-eign languages and teachers should try their best to dis-cover means to overcome this.This paper analyzes theforms and causes of Chinglish,which is created byadult Chinese learners of English through their moth-er-tongue interference.After a contrastive study ofsome linguistic features between Chinese and English,the author lists ten common forms of Chinglish,il-lustrated with examples from his own teaching prac-tice,and points out their respective causes and somepossible measures to eradicate them. | He Mingzhu Zhuzhou Teachers College | 2000 | Chinese Journal of Applied Linguistics2000，23，4： | 14 |
| 8 | Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG显示文摘Two recently engineered SpCas9 variants, namely xCas9 and Cas9-NG, show promising potential in improving targeting specificity and broadening the targeting range. In this study, we evaluated these Cas9 variants in the model and crop plant, rice. We first tested xCas9-3.7, the most effective xCas9 variant in mammalian cells, for targeted mutagenesis at 16 possible NGN PAM (protospacer adjacent motif) combinations in duplicates. xCas9 exhibited nearly equivalent editing efficiency to wild-type Cas9 (Cas9-WT) at most canonical NGG PAM sites tested, whereas it showed limited activity at non-canonical NGH (H = A, C, T) PAM sites. High editing efficiency of xCas9 at NGG PAMs was further demonstrated with C to T base editing by both rAPOBECI and PmCDAI cytidine deaminases. With mismatched sgRNAs, we found that xCas9 had improved targeting specificity over the Cas9-WT. Furthermore, we tested two Cas9-NG variants, Cas9-NGv1 and Cas9-NG, for targeting NGN PAMs. Both Cas9-NG variants showed higher editing efficiency at most non-canonical NG PAM sites tested, and enabled much more efficient editing than xCas9 at AT-rich PAM sites such as GAT, GAA, and CAA. Nevertheless, we found that Cas9-NG variants showed significant reduced activity at the canonical NGG PAM sites. In stable transgenic rice lines, we demonstrated that Cas9-NG had much higher editing efficiency than Cas9-NGv1 and xCas9 at NG PAM sites. To expand the base-editing scope, we developed an efficient C to T base-editing system by making fusion of Cas9-NG nickase (D10A version), PmCDAI, and UGI. Taken together, our work benchmarked xCas9 as a high-fidelity nuclease for targeting canonical NGG PAMs and Cas9-NG as a preferred variant for targeting relaxed PAMs for plant genome editing. | Zhaohui Zhong Simon Sretenovic Qiurong Ren Lijia Yang Yu Bao Caiyan Qi Mingzhu Yuan Yao He Shishi Liu Xiaopei Liu Jiaheng Wang Lan Huang Yan Wang Dibin Baby David Wang Tao Zhang Yiping Qi Yong Zhang | 2019 | Molecular Plant2019，12，7： | 13 |
| 9 | Changes of nutrient concentrations and N:P:Si ratios and their possible impacts on the Huanghai Sea ecosystem显示文摘To investigate the impacts of nutrient concentrations and N:P:Si ratios on the ecosystem of the Huanghai Sea (Yellow Sea), the current status and long-term variation of nutrients concentrations and ratios as well as phytoplankton community structure in the Huanghai Sea were collected and analyzed. The results reveal great annual and seasonal fluctuations in the nutrient concentrations and N:P:Si ratios during 1998-2008 with no clear pattern observed in the whole region. Yet on a seasonal scale of spring and in the coastal regions such as the Jiaozhou Bay and Sanggou Bay, the increase of DIN concentration and N:P ratio as well as the decrease of phosphate and silicate concentrations and Si:N ratios were relatively significant. Many pelagic ecosystem changes have occurred concurrent with these changes of the nutrient regime, such as the recent increase of primary production, changes of phytoplankton chlorophyll a biomass and abundance, an increase of eutrophication, and occurrence of HABs. In addition, new trends in the variation of nutrients seem to be developing in some particular transect such as 36°N, which suggests that long-term and systematic ecosystem monitoring in the Huanghai Sea is necessary. | FU Mingzhu WANG Zongling PU Xinming XU Zongjun ZHU Mingyuan | 2012 | Acta Oceanologica Sinica2012，31，4： | 13 |
| 10 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 11 | Opening time and filling pattern of the Neoproterozoic Kangdian Rift Basin,western Yangtze Continent,South China显示文摘The Neoproterozoic Kangdian Rift Basin is a continental rift basin in the western Yangtze Continent.Determining its time of opening and subsequent filling pattern is an important aspect of understanding the formation and evolution of the Yangtze Continent,South China.The Luliang Formation is the early filling in the eastern part of this rift basin,and its deposition age and filling sequence are significant for studies of the regional stratigraphic correlation,opening time,and filling pattern of this basin.Having been correlated to the upper part of the Mesoproterozoic Kunyang Group or to the Neoproterozoic Chengjiang Formation,the age and regional stratigraphic correlation of the Luliang Formation have long been uncertain.This is due to a lack of reliable absolute age constraints.To address this issue,the first zircon SHRIMP U-Pb geochronology has been established for this formation,yielding two high-precision isotopic ages of 818.6±9.2 and 805±14 Ma for the tuff layers at the bottoms of the lower and upper members of the Luliang Formation,respectively.Given the error factor,the bottom age of the lower member of the Luliang Formation can be interpreted as ca.820 Ma,corresponding to the bottom age of the lower part of the Banxi Group,which is the early filling of the Neoproterozoic Xianggui Rift Basin,a representative basin of the Neoproterozoic rift basins in the Yangtze Continent,South China.The bottom age of the upper member of the Luliang Formation can be interpreted as ca.800±5 Ma,corresponding to the bottom age of the Chengjiang Formation in the western part of the Neoproterozoic Kangdian Rift Basin and also corresponding to the bottom age of the upper part of the Banxi Group in the Neoproterozoic Xianggui Rift Basin.These ages indicate that the Neoproterozoic Kangdian Rift Basin shares the same opening time and filling sequences as those of the other Neoproterozoic rift basins in South China.Basin analysis shows that the Neoproterozoic Kangdian Rift Basin is a typical half-graben basin,with its main boundary fault in the west and basin center in the east.This basin consisted of mini unidirectional half-graben basins in its juvenile stage and simplified to become a large united half-graben basin in its mature stage,i.e.,a supradetachment basin. | ZHUO JieWen JIANG XinSheng WANG Jian CUI XiaoZhuang XIONG GuoQing LU JunZe LIU JianHui MA MingZhu | 2013 | Science China Earth Sciences2013，56，10： | 12 |
| 12 | Enhanced Poly(ethylene terephthalate)Hydrolase Activity by Protein Engineering显示文摘Poly(ethylene terephthalate)hydrolase(PETase)from Ideonella sakaiensis exhibits a strong ability to degrade poly(ethylene terephthalate)(PET)at room temperature,and is thus regarded as a potential tool to solve the issue of polyester plastic pollution.Therefore,we explored the interaction between PETase and the substrate(a dimer of the PET monomer ethylene terephthalate,2PET),using a model of PETase and its substrate.In this study,we focused on six key residues around the substrate-binding groove in order to create novel high-efficiency PETase mutants through protein engineering.These PETase mutants were designed and tested.The enzymatic activities of the R61A,L88F,and I179F mutants,which were obtained with a rapid cell-free screening system,exhibited 1.4 fold,2.1 fold,and 2.5 fold increases,respectively,in comparison with wild-type PETase.The I179F mutant showed the highest activity,with the degradation rate of a PET film reaching 22.5 mg perμmol·L^-1 PETase per day.Thus,this study has created enhanced artificial PETase enzymes through the rational protein engineering of key hydrophobic sites,and has further illustrated the potential of biodegradable plastics. | Yuan Ma Mingdong Yao Bingzhi Li Mingzhu Ding Bo He Si Chen Xiao Zhou Yingjin Yuan | 2018 | Engineering2018，4，6： | 10 |
| 13 | Dynamic contrast-enhanced MRI versus ^(18)F-FDG PET/CT: Which is better in differentiation between malignant and benign solitary pulmonary nodules?显示文摘Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging(DCE-MRI) with that of ^(18)F-fluorodeoxyglucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules(SPNs).Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs. All these patients underwent DCE-MRI and ^(18)F-FDG PET/CT examinations. The quantitative MRI pharmacokinetic parameters, including the trans-endothelial transfer constant(K^(trans)), redistribution rate constant(K_(ep)), and fractional volume(Ve), were calculated using the Extended-Tofts Linear two-compartment model. The ^(18)F-FDG PET/CT parameter, maximum standardized uptake value(SUV_(max)), was also measured. Spearman's correlations were calculated between the MRI pharmacokinetic parameters and the SUV_(max) of each SPN. These parameters were statistically compared between the malignant and benign nodules. Receiver operating characteristic(ROC) analyses were used to compare the diagnostic capability between the DCE-MRI and ^(18)F-FDG PET/CT indexes.Results: Positive correlations were found between K^(trans) and SUV_(max), and between K_(ep) and SUV_(max)(P<0.05).There were significant differences between the malignant and benign nodules in terms of the K^(trans), K_(ep) and SUV_(max) values(P<0.05). The areas under the ROC curve(AUC) of K^(trans), K_(ep) and SUV_(max) between the malignant and benign nodules were 0.909, 0.838 and 0.759, respectively. The sensitivity and specificity in differentiating malignant from benign SPNs were 90.6% and 82.4% for K^(trans); 87.5% and 76.5% for K_(ep); and 75.0% and 70.6%for SUV_(max), respectively. The sensitivity and specificity of K^(trans) and K_(ep) were higher than those of SUV_(max), but there was no significant difference between them(P>0.05).Conclusions: DCE-MRI can be used to differentiate between benign and malignant SPNs and has the advantage of being radiation free. | Feng Feng Fulin Qiang Aijun Shen Donghui Shi Aiyan Fu Haiming Li Mingzhu Zhang Ganlin Xia Peng Cao | 2018 | Chinese Journal of Cancer Research2018，30，1： | 10 |
| 14 | Rainfall interception by sand-stabilizing shrubs related to crown structure显示文摘On the edge of the Tengger Desert in northern China,revegetation has changed the landscape from moving dunes to stabilized dunes covered by shrubs,which further modifies the pattern of rainfall redistribution.To study rainfall interception loss by shrubs and its relationship to rainfall properties and crown structure,throughfalls passing through crowns of Artemisia ordosica Krash.and Caragana korshinskii Kom.were measured using nine PVC cups under the canopy of each of the two shrubs during 73 rain events over a three-year period,with total rainfall of 260.9 mm.Interception losses of gross rainfall by A.ordosica and C.korshinskii account for 15% and 27% of the total on a crown area basis,and 6% and 11% on a ground area basis,respectively.Individual throughfall(T) and interception(I) were significantly related to rainfall amount(Pg),duration(D),and intensity(R).Ratios of throughfall to rainfall(T/Pg) and interception to rainfall(I/Pg) were not only significantly related to Pg,D,and R,but also to shrub species,and interactions of species with crown volume(CV) and leaf area index(LAI).Under most rain events,interceptions by C.korshinskii with greater CV and LAI were significantly higher than those by A.ordosica,and more rainfall interception occurred at locations closer to the stems of the two shrubs.For C.korshinskii,I/Pg had a significant positive linear relation with CV and LAI,while T/Pg had a significant negative linear relation with them.CV has a greater influence on T/Pg and I/Pg than does LAI.Using a regression method,canopy water storage capacities are estimated to be 0.52 and 0.68 mm,and free throughfall coefficient to be 0.62 and 0.47 for A.ordosica and C.korshinskii,respectively. | ZhiShan Zhang 1*,XinRong Li 1,XueJun Dong 2,XiaoHong Jia 1,MingZhu He 1,HuiJuan Tan 1 1.Shapotou Desert Research and Experiment Station,Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou,Gansu 730000,China.2.Central Grasslands Research Extension Center,North Dakota State University,Streeter,ND 58483,USA. | 2009 | Research in Cold and Arid Regions2009，1，2： | 9 |
| 15 | Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer:A phase II open-label clinical study显示文摘Objective: The aim of this trial was to compare both the efficacy and the safety of a weekly nanoparticle albumin-bound paclitaxel(nab-paclitaxel) plus cisplatin vs. gemcitabine plus cisplatin in patients with advanced non-small-cell lung cancer(NSCLC).Methods: A total of 84 participants received either 100 mg/m^2 nab-paclitaxel each week on d 1, 8 and 15 of a 28 day cycle, as well as cisplatin 75 mg/m^2 on d 1 every three weeks(nab-TP arm); or gemcitabine 1,000 mg/m^2 on d 1 and 8, plus cisplatin 75 mg/m^2 on d 1 every three weeks(GP arm). The primary end point was progression-free survival(PFS). The secondary end points were overall response rate(ORR) and overall survival(OS).Results: According to our analysis, the median PFS was 4.8 months for the nab-TP arm vs. 5.2 months for the GP arm(P=0.55). Analysis showed the median OS was 14.6 months for participants who were in the nab-TP arm vs. 15.1 months for those in the GP arm(P=0.94). Besides, nab-TP showed OS advantages over GP in patients harboring epidermal growth factor receptor(EGFR) mutation(26.7 vs. 15.3 months, P=0.046) and patients with a performance status of 0(23.5 vs. 14.7 months, P=0.020). It was found that incidences of drug-related grade 3 or 4 toxicities were comparable between the two treatment arms.Conclusions: Therefore, it can be seen that weekly nab-TP treatment has a similar efficacy and tolerability to GP treatment for patients who are undergoing their first-line treatment for NSCLC. It could be that survival differences among platinum doublets in the context of both EGFR mutation and performance status have the potential to be the basis for our further clinical trials. | Shanshan Qin Hui Yu Xianghua Wu Zhiguo Luo Huijie Wang Si Sun Mingzhu Huang Jia Jin Zhonghua Tao Jie Qiao Yu Feng Jialei Wang Jianhua Chang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 9 |
| 16 | Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma显示文摘 | Li Mingzhu Zhao Lijun Shen Danhua Li Xiaoping Wang Jianliu Wei Lihui | 2014 | Chinese Medical Journal2014，，8： | 8 |
| 17 | Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing显示文摘Pathogenic bacteria pose a devastating threat to public health.However,because of the growing bacterial antibiotic resistance,there is an urgent need to develop alternative antibacterial strategies to the established antibiotics.Herein,iron-doped carbon dots(Fe-CDs,~3 nm)nanozymes with excellent photothermal conversion and photoenhanced enzyme-like properties are developed through a facile one-pot pyrolysis approach for synergistic efficient antibacterial therapy and wound healing.In particular,Fe doping endows CDs with photoenhanced peroxidase(POD)-like activity,which lead to the generation of heat and reactive oxygen species(ROS)for Gram-positive and Gram-negative bacteria killing.This study demonstrates Fe-CDs have significant wound healing efficiency of Fe-CDs by preventing infection,promoting fibroblast proliferation,angiogenesis,and collagen deposition.Furthermore,the ultrasmall size of Fe-CDs possesses good biocompatibility favoring clinical translation.We believe that the nanozyme-mediated therapeutic platform presented here is expected to show promising applications in antibacterial. | Yunhang Liu Bolong Xu Mingzhu Lu Shanshan Li Juan Guo Fangzhou Chen Xiaolu Xiong Zhe Yin Huiyu Liu Dongsheng Zhou | 2022 | Bioactive Materials2022，7，6： | 7 |
| 18 | Emerging insights into heterotrimeric G protein signaling in plants显示文摘Heterotrimeric guanine nucleotide-binding protein(G protein) signaling is an evolutionary conserved mechanism in diverse eukaryotic organisms.In plants,the repertoire of the heterotrimeric G protein complex,which is composed of the Gα,Gβ,and Gγ subunits,is much simpler than that in metazoans,and the identity of typical G protein-coupled receptors(GPCRs) together with their ligands still remains unclear.Comparative phenotypic analysis in Arabidopsis and rice plants using gain- and loss-of-function mutants of G protein components revealed that heterotrimeric G protein signaling plays important roles in a wide variety of plant growth and developmental processes.Grain yield is a complex trait determined by quantitative trait loci(QTL) and is influenced by soil nitrogen availability and environmental changes.Recent studies have shown that the manipulation of two non-canonical Gy subunits,GS3(GRAIN SIZE 3)and DEP1(DENSE AND ERECT PANICLE 1),represents new strategies to simultaneously increase grain yield and nitrogen use efficiency in rice.This review discusses the latest advances in our understanding of the heterotrimeric G protein signal transduction pathway and its application in improving yield and stress tolerance in crops. | Quan Xu Mingzhu Zhao Kun Wu Xiangdong Fu Qian Liu | 2016 | Journal of Genetics and Genomics2016，43，8： | 6 |
| 19 | Improved Toughness and Thermal Expansion of Non-stoichiometry Gd_(2-x)Zr_(2+x)O_(7+x/2) Ceramics for Thermal Barrier Coating Application显示文摘Gd_2Zr_2O_7 has been considered as a promising thermal barrier coating candidate,but its toughness and thermal expansion coefficient(TEC) need to be improved.In this study,Gd_(2-x)Zr_(2+x)O_(7+x/2)(x = 0,0.1,0.3,0.5,0.7) compounds were produced to improve the toughness and enlarge the TEC.Gd_2Zr_2O_7 and Gd_(1.9)Zr_(2.1)O_(7.05) exhibited pyrochlore structure,while Gd_(2-x)Zr_(2+x)O_(7+x/2)(x=0.3,0.5,0.7) consisted of pyrochlore and t'-ZrO_2 phases.With increasing ZrO_2 content,the pyrochlore in the compounds had decreased lattice parameter,and its ordering degree decreased when x≤0.3,then it almost kept unchanged with higher ZrO_2 content.Among the Gd_(2-x)Zr_(2+x)O_(7+x/2) ceramics investigated,the toughness of the compounds increased with increasing ZrO_2 content,while Gd_(1.7)Zr_(2.3)O_(7.15) exhibited the largest TEC.The related mechanisms were discussed in detail. | Lei Guo Mingzhu Li Yu Zhang Fuxing Ye | 2016 | Journal of Materials Science & Technology2016，32，1： | 6 |
| 20 | Selective Synthesis of Hexagonal Ag Nanoplates in a Solution-Phase Chemical Reduction Process显示文摘Two-dimensional(2-D)Ag nanoplates have surface plasmon resonances which can be tuned from the visible to the near-IR by varying the size and morphology of the nanoplates.Due to their anisotropic structures and different surface energy distributions,Ag nanoplates-especially triangular ones-are kinetically stable and can transform into other nanostructures.Taking advantage of the synergetic effects of HNO_(3)and Cl-in the reduction solution,uniform Ag hexagonal nanoplates(HNPs)have been captured during the transformation of Ag triangular nanoplates(TNPs).The dimensions of the Ag HNPs can be controlled by changing the concentrations of reagents in the reaction or/and reduction solutions.Resonance absorption spectra of the obtained Ag HNPs indicated that their in-plane resonance peaks could be tuned from the visible to the near-IR region,showing their potential applications in medical diagnosis. | Mingzhu Liu Mei Leng Chao Yu Xin Wang Cheng Wang | 2010 | Nano Research2010，3，12： | 5 |
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