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| 1 | Effect of Radial Resistance Gap on the Pressure Drop of a Compact Annular-Radial-Orifice Flow Magnetorheological Valve显示文摘A compact annular-radial-orifice flow magnetorheological(MR)valve was developed to investigate the effects of radial resistance gap on pressure drop.The fluid flow paths of this proposed MR valve consist of a single annular flow channel,a single radial flow channel and an orifice flow channel through structure design.The finite element modelling and simulation analysis of the MR valve was carried out using ANSYS/Emag software to investigate the changes of the magnetic flux density and yield stress along the fluid flow paths under the four different radial resistance gaps.Moreover,the experimental tests were also conducted to evaluate the pressure drop,showing that the proposed MR valve has significantly improved its pressure drop at 0.5 mm width of the radial resistance gap when the annular resistance gap is fixed at 1 mm. | Guoliang Hu Jiawei Zhang Mingke Liao Ruqi Ding | 2018 | Journal of Beijing Institute of Technology2018，27，4： | 4 |
| 2 | 甲羟戊酸通路是疫苗佐剂研发的可药化靶点显示文摘文章简介佐剂是疫苗的一部分,能帮助疫苗更快速、持久地产生免疫应答。在现代疫苗的研发中,佐剂有着不可或缺的作用。但是到目前为止,FDA批准上市的佐剂只有铝佐剂,MF-59,AS03以及AS04等几种。 | 夏贇 谢永华 于正森 Hongying Xiao Guimei Jiang Xiaoying Zhou Yunyun Yang Xin Li Meng Zhao Liping Li Mingke Zheng Shuai Han Zhaoyun Zong Xianbin Meng Haiteng Deng Huahu Ye Yunzhi Fa Haitao Wu Eric Oldfield Xiaoyu Hu 刘万里 石彦 张永辉 | 2019 | 科学新闻2019，0，2： | 0 |
| 3 | Pharmacological inhibition of asparaqinyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer's disease-related pathologies in a senescence-accelerated mouse model显示文摘Background:Currently,there is no cure for Alzheimer's disease(AD).Therapeutics that can modify the early stage of AD are urgently needed.Recent studies have shown that the pathogenesis of AD is closely regulated by an endo/lysosomal asparaginyl endopeptidase(AEP).Inhibition of AEP has been reported to prevent neural degeneration in transgenic mouse models of AD.However,more than 90% of AD cases are age-related sporadic AD rather than hereditary AD.The therapeutic efficacy of AEP inhibition in ageing-associated sporadic AD remains unknown.Methods:The senescence-accelerated mouse prone 8(SAMP8)was chosen as an approximate model of sporadic AD and treated with a selective AEP inhibitor,δ-secretase inhibitor 11.Activation of AEP was determined by enzymatic activity assay.Concentration of soluble amyloid β(Aβ)in the brain was determined by ELISA.Morris water maze test was performed to assess the learning and memory-related cognitive ability.Pathological changes in the brain were explored by morphological and western blot analyses.Results:The enzymatic activity of AEP in the SAMP8 mouse brain was significantly higher than that in the agematched SAMR1 mice.The half maximal inhibitory concentration(IC_(50))for δ-secretase inhibitor 11 to inhibit AEP in vitro was around 150 nM.Chronic treatment with δ-secretase inhibitor 11 markedly decreased the brain AEP activity,reduced the generation of Aβ_(1-40/42) and ameliorated memory loss.The inhibition of AEP with this reagent not only reduced the AEP-cleaved tau fragments and tau hyperphosphorylation,but also attenuated neuroinflammation in the form of microglial activation.Moreover,treatment with 6-secretase inhibitor 11 prevented the synaptic loss and alleviated dendritic disruption in SAMP8 mouse brain.Conclusions:Pharmacological inhibition of AEP can intervene and prevent AD-like pathological progress in the model of sporadic AD.The up-regulated AEP in the brain could be a promising target for early treatment of AD.The δ-secretase inhibitor 11 can be used as a lead compound for translational development of AD treatment. | Ju Wang Hui-Jie Hu Zi-Kai Liu Jing-Jing Liu Shan-Shan Wang Qing Cheng Hong-Zhuan Chen Mingke Song | 2021 | Translational Neurodegeneration2021，10，1： | 0 |
| 4 | Effect of the spectrally selective features of the cover and emitter combination on radiative cooling performance显示文摘Radiative cooling(RC)shows good potential for building energy saving by throwing waste heat to the cosmos in a passive and sustainable manner.However,most available radiative coolers suffer from low cooling flux.The situation becomes even deteriorated in the daytime when radiative coolers are exposed to direct sunlight.To tackle this challenge,an idea of employing both a spectrally selective cover and a spectrally selective emitter is proposed in this study as an alternative approach.A comparative study is conducted among four RC modules with different spectral characteristics for the demonstration of how the spectral profiles of the cover and the emitter affects the RC performance.The results under given conditions show that the RC module with a spectrally selective cover and a spectrally selective emitter(SC/SE)reaches a net RC power of 62.4 W/m^(2)when the solar radiation is 800 W/m^(2),which is about 1.8 times that of the typical RC module with a spectrally non-selective cover and a spectrally selective emitter(n-SC/SE).When the ambient temperature is 30°C,the SC/SE based RC module realizes a daytime sub-ambient temperature reduction of 20.0°C,standing for a further temperature decrement of 9.2°C compared to the n-SC/SE based RC module. | Mingke Hu Suhendri Bin Zhao Xianze Ao Jingyu Cao Qiliang Wang Saffa Riffat Yuehong Su Gang Pei | 2021 | Energy and Built Environment2021，2，3： | 0 |
| 5 | Flexible building-integrated solar energy technologies towards carbon neutrality显示文摘In our pursuit of a sustainable future,the role of buildings in reducing carbon emissions cannot be overstated.Building energy consumption is a significant contributor to fossil energy usage and CO_(2)emissions,emphasizing the need for innovative solutions to minimize the environmental impact.With a global commitment to achieving carbon neutrality,the building sector becomes a crucial battleground in this endeavor.Solar energy,characterized by its cleanliness and near-infinite availability,holds great promise for achieving significant energy savings and reducing carbon footprints.Given the proportional energy density of solar radiation to building energy requirements,solar energy technologies are frequently integrated with buildings to foster low-energy and low-carbon strategies and propel the path to sustainability forward. | Mingke Hu Jingyu Cao Wei Wu | 2023 | Building Simulation2023，16，10： | 0 |
| 6 | A spectrally selective surface structure for combined photothermic conversion and radiative sky cooling显示文摘The sun and outer space are the ultimate heat and cold sources for the earth,respectively.They have significant potential for renewable energy harvesting.In this paper,a spectrally selective surface structure that has a planar polydimethylsiloxane layer covering a solar absorber is conceptually proposed and optically designed for the combination of photothermic conversion(PT)and nighttime radiative sky cooling(RC).An optical simulation is conducted whose result shows that the designed surface structure(i.e.,PT-RC surface structure)has a strong solar absorption coefficient of 0.92 and simultaneously emits as a mid-infrared spectral-selective emitter with an average emissivity of 0.84 within the atmospheric window.A thermal analysis prediction reveals that the designed PTRC surface structure can be heated to 79.1℃higher than the ambient temperature in the daytime and passively cooled below the ambient temperature of approximately 10℃in the nighttime,indicating that the designed PT-RC surface structure has the potential for integrated PT conversion and nighttime RC utilization. | Bin ZHAO Xianze AO Nuo CHEN Qingdong XUAN Mingke HU Gang PEI | 2020 | Frontiers in Energy2020，14，4： | 0 |
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