|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pt/Y2O3:Eu3+ composite nanotubes: Enhanced photoluminescence and application in dye-sensitized solar cells显示文摘Y (哦)3:Eu3+ nanotubes 用一个灵巧的热水的方法被综合,然后,磅粒子在使用真空抽取的联合并且退火的 nanotubes 的表面上被种。产生 Pt/Y 2 O 3:Eu3+合成 nanotubes 不仅在 255-nm 或 468-nm 刺激下面展出了提高的红光而且能也被用来改进敏化染料的太阳能电池的效率,导致8.33%的效率,没有合成 nanotubes ,它与一节太阳能电池相比代表11.96%的重要改进。电气化学的阻抗光谱学结果显示 TiO 2-dye|I 3-/I - 电解质的界面的抵抗 TiO 2-Pt/Y2 合成房间多是的 O 3:Eu3+ 比一个纯 TiO 2 房间的小。另外, TiO 2-Pt/Y2 O 3:Eu3+ 合成房间比纯 TiO 2 房间展出了一更短的电子运输时间和更长的电子再结合时间。 | Mingqi Yu Jiamin Su Guofeng Wang Yadong Li | 2016 | Nano Research2016，9，8： | 6 |
| 2 | Tumor-targeted delivery of siRNA to silence Sox2 gene expression enhances therapeutic response in hepatocellular carcinoma显示文摘RNA interference(RNAi)is one of the most promising methods for the treatment of malignant tumors.However,developing an efficient biocompatible delivery vector for small interfering RNA(siRNA)remains a challenging issue.This study aimed to prepare a non-viral tumor-targeted carrier,named RGDfC-modified functionalized selenium nanoparticles(RGDfC-SeNPs).RGDfC-SeNPs were used to selectively deliver siSox2 to HepG2 liver cancer cells and tissues for the treatment of hepatocellular carcinoma(HCC).In the current study,RGDfC-SeNPs were successfully synthesized and characterized.It was shown that RGDfC-SeNPs could effectively load siSox2 to prepare an antitumor prodrug RGDfC-Se@siSox2.RGDfC-Se@siSox2 exhibited selective uptake in HepG2 liver cancer cells and LO2 normal liver cells,indicating RGDfC-SeNPs could effectively deliver siSox2 to HepG2 liver cancer cells.RGDfC-Se@siSox2 entered HepG2 cells via clathrin-mediated endocytosis by firstly encircling the cytoplasm and then releasing siSox2 in the lysosomes.RGDfC-Se@siSox2 could effectively silence Sox2 and inhibit the proliferation,migration and invasion of HepG2 cells.RGDfC-Se@siSox2 induced HepG2 cells apoptosis most likely via overproduction of reactive oxygen species and disruption of the mitochondrial membrane potentials.Most importantly,RGDfC-Se@siSox2 significantly inhibited the tumor growth in HepG2 tumor-bearing mice without obvious toxic side effects.These studies indicated that RGDfC-SeNPs may be an ideal gene carrier for delivering siSox2 to HepG2 cells and that RGDfC-Se@siSox2 may be a novel and highly specific gene-targeted prodrug therapy for HCC. | Yu Xia Guoyi Tang Yi Chen Changbing Wang Min Guo Tiantian Xu Mingqi Zhao Yongjian Zhou | 2021 | Bioactive Materials2021，6，5： | 2 |
| 3 | A new way to analyze the traditional Chinese medicine syndrome:heat toxin syndrome in cerebral infarction显示文摘Objective:To establish a diagnostic system for heat toxin syndrome of acute cerebral infarction.Based on this toxin syndrome diagnostic system,the general principles of heat toxin development will be uncovered,and the critical turning point at which the heat toxin syndrome occurs will also be explored.Methods:In this study,a total of 271 hypertension patients with cerebral infarction within 72 h were recruited from the Affiliated Dongfang Hospital of the Beijing University of Chinese Medicine,the Affiliated Dongzhimen Hospital of Beijing University of Chinese Medicine,the Affiliated Renmin Hospital of Peking University,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,the Affiliated Hospital of Changchun University of Traditional Chinese Medicine,the Affiliated Hospital of Hebei University of Traditional Chinese Medicine and China Meitan General Hospital from August,2008,to December,2009.The patients’Chinese medical information was recorded on days 1,3,5,7,and 14 during their hospitalizations.The medical records were recorded according to traditional Chinese medicine(TCM)theory and included the serum marker levels at the beginning and at the end of the trial.The time line was also analyzed.Results:The level of Hs-CRP,PAG,NSE,OX-LDL,and MMP-9 were abnormal and,were higher in CI patients compared to hypertension patients.In the study of the heat toxin diagnosis system,according to the entropy clustering results,30 combinations of the medical information can be sorted into the traditional syndromes,but 13 combinations cannot be sorted.To obtain more precise symptoms related to the heat toxins,a logistic regression equation was set up with the variables from the unsorted medical information;the dependent variables were fever and BP fluctuation.Weighted variables were obtained.MLP analysis demonstrated that the diagnosis model was stable and precise.The accuracy reached 83.82%.The ROC test showed that seven points of the diagnosis system was the best cutting point,with a sensitivity of 0.857 and a specificity of 0.955.Progressing stroke was related to heat toxin syndrome.When the turning point appeared,the combination of symptoms,such as coma,aphasia,gummy eyes,and halitosis,predicted the deterioration or recovery of CI.The heat toxin syndrome existed in every subtype of CI;however,the observed heat toxin levels were highest in PACI and lowest in LACI.Meanwhile,blood and sputum stasis syndromes transformed into heat toxicity were one source of heat toxin syndrome.Conclusion:Heat toxin syndrome,as well as qi/blood/sputum stasis,co-existed in the CI patients,and the transformation frequently appeared during the process.Three to five days after the onset of CI was the turning point,at which time several combinations of medical indicators make it possible to predict the development of CI. | Zhichen Zhang Shaozhen Ji Xuejie Yu Xianglan Jin Liping Zhang Rongjuan Guo Hong Zheng Mingqi Wang Yunling Zhang | 2014 | Journal of Traditional Chinese Medical Sciences2014，1，1： | 1 |
| 4 | Adaboost and multi-orientation 2D Gabor-based noisy iris recognition显示文摘 | Qi Wang Xiangde Zhang Mingqi Li Xiaopeng Dong Qunhua Zhou Yu Yin | 2011 | Pattern Recognition Letters2011，，8： | 1 |
| 5 | Observation and analysis of morphology abnormalities in development of Oryzias melastigma embryos显示文摘Fish embryos are widely used as models in toxicology,drug development,and human disease research because of their high sensitivity,observability,and operability,providing the basis for an in-depth understanding of the embryogenesis.Increasing studies have indicated that birth defects are hereditary.In this study,we used Oryzias melastigma as a model to conduct a study of 185-day embryogenesis and observed self-induced non-pathological abnormal embryogenesis.O.melastigma experienced pre-puberty stage,adolescence stage,and senescence stage,and individuals produced up to 102 eggs per day.However,the fecundity was markedly reduced during the senescent stage.During the active egg and blastodisc stages,pseudo-fertilization and pseudo-blastocysts were observed.During cleavage at the 4-to 32-cell stages,we observed blastomeres separation or dislocation.Excessively separated blastomeres formed double blastoderms,eventually resulting in conjoined twins.During the blastula stage,we observed abnormally increased cell volume,narrowed and elongated blastocysts,and abnormally coated blastoderms.At the organogenesis stage,we observed abnormal numbers of Kupff er’s vesicles and conjoined twins.Abnormality in the location and number of oil droplets were observed in various development stages.Abnormal development was more commonly observed in fertilized eggs produced by broodstock in pre-puberty or senescence stages,which is probably related to the age of fish and the egg quality.This study can provide the materials for comparative analysis in toxicological and molecular studies of O.melastigma,and may provide evidence for other economic fish that produce sticky eggs. | Jingjing SONG Haiyi WU Kaikai LIU Wendan CHI Shanshan GE Zhipeng ZHANG Mingqi WANG Yi YU Daode YU | 2021 | Journal of Oceanology and Limnology2021，39，4： | 0 |
| 6 | REAL TIME RECONSTRUCTION OF FLUID IN VIDEO显示文摘This paper puts forward a new method of realtime reconstruction of fluid in natural scene.It takes the measure of combination of image analysis and LBM(Lattice Boltz-mann Methods).First,employs LK(Lucas–Kanade)method to calculate the dense optical flow,and then takes LBM to obtain the joint force of central particles for the initial result.After backfilling the velocity vectors field,it adopts the K-means cluster to obtain several classes,in each class,it takes advantage of the Rayleigh distribution to fit the height field of fluid.Finally,the reconstruction result of fluid is obtained.In addition,it demonstrates the results of the height field of fluid in the experiment.Fur-ther experiments shows that it is a valid method of fluid reconstruction with real time and can be used in the study of natural landscape fluid with efficiency and feasibility. | HONGYAN QUAN MINGQI YU XIAO SONG YAN GAO | 2013 | International Journal of Modeling, Simulation, and Scientific Computing2013，4，4： | 0 |
| 7 | Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells显示文摘Here,we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation.By excising the natural poly-adenylation(poly-A)signal of target genes and replacing it with a synthetic control region harboring RNA-binding protein(RBP)-specific aptamers,cap-dependent translation is rendered exclusively dependent on synthetic translation initiation factors(STIFs)containing different RBPs engineered to conditionally associate with different eIF4F-binding proteins(eIFBPs).This modular design framework facilitates the engineering of various gene switches and intracellular sensors responding to many user-defined trigger signals of interest,demonstrating tightly controlled,rapid and reversible regulation of transgene expression in mammalian cells as well as compatibility with various clinically applicable delivery routes of in vivo gene therapy.Therapeutic efficacy was demonstrated in two animal models.To exemplify disease treatments that require on-demand drug secretion,we show that a custom-designed gene switch triggered by the FDA-approved drug grazoprevir can effectively control insulin expression and restore glucose homeostasis in diabetic mice.For diseases that require instantaneous sense-and-response treatment programs,we create highly specific sensors for various subcellularly(mis)localized protein markers(such as cancer-related fusion proteins)and show that translation-based protein sensors can be used either alone or in combination with other cell-state classification strategies to create therapeutic biocomputers driving self-sufficient elimination of tumor cells in mice.This design strategy demonstrates unprecedented flexibility for translational regulation and could form the basis for a novel class of programmable gene therapies in vivo. | Jiawei Shao Shichao Li Xinyuan Qiu Jian Jiang Lihang Zhang Pengli Wang Yaqing Si Yuhang Wu Minghui He Qiqi Xiong Liuqi Zhao Yilin Li Yuxuan Fan Mirta Viviani Yu Fu Chaohua Wu Ting Gao Lingyun Zhu Martin Fussenegger Hui Wang Mingqi Xie | 2024 | Cell Research2024，34，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员