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| 1 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 2 | Targeted biodegradable dendritic MRI contrast agent for enhanced tumor imaging显示文摘 | Mingzhou Ye Yue Qian Jianbin Tang Hongjie Hu Meihua Sui Youqing Shen | 2013 | Journal of Controlled Release2013，，： | 1 |
| 3 | Targeted biodegradable dendritic MRI contrast agent for enhanced tumor imaging显示文摘 | Mingzhou Ye Yue Qian Jianbin Tang Hongjie Hu Meihua Sui Youqing Shen | 2013 | Journal of Controlled Release2013，，3： | 1 |
| 4 | STUDY ON A PRECISE ON-SPOT CALIBRATION METHOD FOR DISTRIBUTED STEREO REFERENCE POSITION-SETTING显示文摘A high precision method used for on-spot calibration of distributed stereo reference position Setting is pre-sented. The high measuring accuracy in stereo reference calibration is derived from using a high precision water level in-strument and an accurate height vernier caliper. It settles the problem of reference calibration effectively and accurately,without using large coordinate measuring machines (CMM). It is more adaptable and precise than traditional calibrationmethods applying theodolites or autocollimators. The error sources of this method are analyzed in detail and severalmethods are developed to eliminate the calibration error. An optimizing swallowtail-like anchor target is developed. Ex-periments show that the calibration accuracy can be limited within 0.06 mm in the range of 3~5 m and 0.03 mm withoptimizing anchor target. This method can be widely used in on-spot calibration. | Wang Zhong Kou Xinyu Chen Mingzhou Ye ShenghuaState Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University,Tianjin 300072, ChinaXiong ChunbaoTianjin University | 2002 | Chinese Journal of Mechanical Engineering2002，15，4： | 0 |
| 5 | Alteration of the respiratory microbiome in COVID-19 patients with different severities显示文摘Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients. | Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li Mingzhou Xie Yangqing Zhan Ye Lin Zhun Li Min Xie Zhaoming Chen Airu Zhu Ruosu Ying Le Yu Jin cun Zhao Shuai Cheng Li Weiping Cai Feng Ye | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 6 | Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms显示文摘Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon rupture.Currently,there is no approved drug therapy for AAA.Surgical repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed cases.It is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA progression.We contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery methods.There is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and progression.In this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic target.Indeed,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in vivo.In parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug delivery.This NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of AAA.In summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA. | Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang | 2023 | Bioactive Materials2023，，8： | 0 |
| 7 | Synthesis and Properties of a Biodegradable Dendritic Magnetic Resonance Imaging Contrast Agent显示文摘新奇可被细菌破坏的树枝状的对比代理人(DCA ) 基于聚酯 dendrimers 被综合并且描绘。DCA 在生理的 pH 很快在酸的 pH,而是 hydrolyzed 是稳定的,它象小分子 CA 的一样使 DCA 的长期的 Gd3+ 保留变为低。他们 10.2 ~ 17.5 L 祬的纵的 relaxivities?? | Tingting Li Yue Qian Mingzhou Ye Jianbin Tang Hongjie Hu Youqing Shen | 2014 | Chinese Journal of Chemistry2014，32，1： | 0 |
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