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| 1 | Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft显示文摘Polyphyllin 我(PPI ) ,从巴黎 polyphyllin 的根茎提取的小分子的单体,在以前的学习显示出强壮的 anticancer 效果。人的肺腺癌 A549 房间,人的肺有鳞的房间癌 SK-MES-1 房间,和人的肺大房间癌 H460 房间与 PPI 有教养然后对待。房间增长和 apoptosis 被 3- 测量[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物试金,流动 cytometry,西方的污点分析,和 DNA 梯子。Athymic 裸体老鼠适用肿瘤与 PPI 被注射,并且肿瘤生长被记录。我们的结果证明 PPI 显著地禁止了房间衬里的三非小的房间肺癌症(NSCLC ) 的增长,与为 A549, H460,和 SK-MES-1 的 1.24, 2.40,和 2.33 g/ml 的禁止的集中(IC50 ) 房间分别地。在为 24 h 与 PPI 的 2.5 g/ml 被对待以后, A549 房间的 apoptotic 率是 39.68% ,它比控制的显著地高。肿瘤生长显著地与在裸体老鼠与 cisplatin (DDP ) 或 PBS 对待的组相比在对待 PPI 的组被禁止。在在 vitro 并且在 vivo 的 NSCLC 房间的 PPI 展览 antitumor 能力,它可能与 apoptosis 有关由 PPI 导致了。 | Minjian Kong Junqiang Fan Aiqiang Dong Haifeng Cheng Rongzhen Xu | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 15 |
| 2 | Suppression of Type 1 Insulin-like Growth Factor Receptor Expression by Small Interfering RNA Inhibits A549 Human Lung Cancer Cell Invasion in vitro and Metastasis in Xenograft Nude Mice显示文摘癌症侵略和转移,包含许多病理学的过程和 cytophysiological 变化,贡献肺癌症的高死亡。类型 1insulin-like 生长因素受体(IGF-1R ) ,把前进和侵略与癌症联系了,是在肺癌症的一个潜在的反侵略和反转移目标。禁止肺癌症房间的侵略性质,我们在由小介入 RNA ( siRNA )技术的 A549 人的肺癌症房间的成功地下面调整的 IGF-1R 基因表达,并且评估了它的效果oninvasion相关的基因表达,在 vitro 侵略的肿瘤房间,并且在有为 IGF-1R 表示发卡 siRNA 的一个原生质标志的异种皮移植 nudemice.A549 房间 transfected 的转移在 mRNA 水平以及蛋白质 level.Inbiological 试金显示出一个显著地减少的 IGF-1R 表达式, transfected A549 房间显示出 cell-matrixadhesion ,移植和侵略的重要减小。与这些结果一致,我们发现那条下面规定大减小附随地在侵略相关的基因表达伴随的 ofIGR-1R , includingMMP-2 , MMP-9 , u-PA ,并且为 IGF-1R 的 plasmidexpressing 发卡 siRNA 的 IGF-1R 特定的下游的 p-Akt.Direct 尾巴静脉注射显著地在结果显示出的 nudemice.Our 禁止了肺转移的形成是的 siRNA 的治疗学的潜力为在禁止肺癌症侵略和转移的基因治疗的一个方法。 | Jianfang QIAN~1 Aiqiang DONG~1 Minjian KONG~1 Zhiyuan MA~2 Junqiang FAN~1 and Guanyu JIANG~3 ~1Department of Cardiothoracic Surgery,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China ~2Department of Cardiovascular Surgery,Shanghai Jiaotong University Affiliated First People’s Hospital,Shanghai 200080,China ~3Department of Emergency,Second Affiliated Hospital School of Medicine,Zhejiang University,Hangzhou 310009,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 9 |
| 3 | Progress and challenges of carbon-fueled solid oxide fuel cells anode显示文摘Carbon-fueled solid oxide fuel cells(CF-SOFCs)can electrochemically convert the chemical energy in carbon into electricity,which demonstrate both superior electrical efficiency and fuel utilisation compared to all other types of fuel cells.However,using solid carbon as the fuel of SOFCs also faces some challenges,the fluid mobility and reactive activity of carbon-based fuels are much lower than those of gaseous fuels.Therefore,the anode reaction kinetics plays a crucial role in determining the electrochemical performance of CF-SOFCs.Herein,the progress of various anodes in CF-SOFCs is reviewed from the perspective of material compositions,electrochemical performance and microstructures.Challenges faced in developing high performance anodes for CF-SOFCs are also discussed. | Minjian Ma Xiaoxia Yang Jinshuo Qiao Wang Sun Zhenhua Wang Kening Sun | 2021 | Journal of Energy Chemistry2021，30，5： | 8 |
| 4 | Knockdown of insulin-like growth factor 1 receptor enhances chemosensitivity to cisplatin in human lung adenocarcinoma A549 cells显示文摘RNA 调停干扰的像胰岛素的生长的效果响应在在 vivo 并且在 vitro 的肺癌症房间线 A549 的 cisplatin (DDP ) 的因素 1 受体(IGF1R ) 基因 silencing 用表示短发卡 RNA (shRNA ) 到 IGF1R 的二个原生质标志被调查。A549 房间是有表示每 shRNA 的原生质标志的 transfected 然后与 DDP 对待。半量的反向的 transcription-PCR 和蛋白质印迹分析被用来检测 IGF1R 的表示。在 athymic 裸体人老鼠的 MTT 试金,流动 cytometry 和肿瘤生长试金被用来估计 chemosensitivity 到 DDP 后面的 IGF1R 击倒。我们的数据证明有 shRNA 的 A549 房间的转染在蛋白质水平在 mRNA 水平并且在 89.8% 在 78.9% 导致了 IGF1R 的特定的 silencing。IGF1R 的下面规定显著地提高了房间敏感到 DDP,减少在在 24 h, 48 h 和 72 h 的 A549 房间的 DDP 的 IC50,并且在 G (0 )/G (1 ) 保留了 77.5% A549 房间阶段。而且,在有 DDP 处理的联合的 IGF1R 的调停 shRNA 的 silencing 在超过 60% 在尺寸和重量提高了肿瘤生长的抑制并且增加了 apoptosis 超过 75% 什么时候与在 vivo 的控制相比。由 shRNA 的 IGF1R 基因表达的抑制在 vitro 并且在 vivo 提高 A549 房间的 chemosensitivity 到 DDP,显示象为在治疗肺癌症的基因治疗的一个方法的 RNA 干扰的治疗学的潜力。 | Aiqiang Dong Minjian Kong Zhiyuan Ma Jianfang Qian Haifeng Cheng Xiaohong Xu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 4 |
| 5 | MicroRNA-150 aggravates H2O2-induced cardiac myocyte injury by down-regulating c-myb gene显示文摘MicroRNAs (miRNAs ) 是经由降级或他们的目标基因的翻译抑制在 post-transcriptional 规定起一个重要作用的非编码的 RNA 的一个班。MicroRNA-150 (miR-150 ) 在调整 B 和 T 淋巴细胞的发展起一个重要作用。尽管 miR-150 的 dysregulation 在人的心肌的梗塞被证实,很少响应反应的氧种类(ROS ) 关于 miR-150 的生物功能被知道在心脏的 myocytes 的调停的基因规定。用量的即时反向的抄写聚合酶链反应,我们证明 miR-150 的水平在在有氢过氧化物(H2O2 ) 的治疗以后的心脏的 myocytes 是起来调整的。在调停 H2O2 的基因规定识别 miR-150 的潜在的角色,我们调制了表示用 miR-150 禁止者的 miR-150 和 miR-150 模仿。结果证明 miR-150 的那 silencing 表情减少了导致 H2O2 的心脏的房间死亡和 apoptosis。在淋巴细胞, c-myb 是 miR-150 的一个直接目标。在心脏的 myocytes,我们发现 c-myb 也涉及 miR-150-mediated 导致 H2O2 的心脏的房间死亡。这些结果建议 miR-150 在心脏的 myocytes 参予调停 H2O2 的基因规定和功能的调整。MiR-150 可以在与 ROS 有关的心疾病起一个必要作用,例如心脏的肥大,心失败,心肌的梗塞,和心肌的 ischemia/reperfusion 损害。 | Xuebiao Li Minjian Kong Darning Jiang Jianfang Qian Qunjun Duan Aiqiang Dong | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 3 |
| 6 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 7 | Experimental study on the noise reduction of an industrial forward-curved blades centrifugal fan显示文摘 | Qi Datong Mao Yijun Liu Xiaoliang Yuan Minjian | 2009 | Applied Acoustics2009，，8： | 2 |
| 8 | C-glycosylflavones from the leaves of Iris tectorum Maxim.显示文摘A new C-glycosylflavone,5-hydroxyl-4′,7-dimethoxyflavone-6-C-[0-(α-L-3″-acetylrhamno-pyranosy)-1→2-β-D-glucopyranoside](1),along with five known C-glycosylflavones,5-hydroxy-4′,7-dimethoxyfavone-6-C-[0-(α-L-2′″-acetylrhamnopyranosy1)-1→2-β-D-glucopyranoside](2),embinin(3),embigenin(4),swertisin(5)and swertiajaponin(6)were isolated from the leaves of Iris tectorum Maxim.Their structures were elucidated on the basis of extensive NM R experiments and spectral methods and their cytotoxic activities against A 549(lung cancer)human cell lines were determined. | Yuhan Ma Huan Li Binbin Lin Guokai Wang Minjian Qin | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 2 |
| 9 | Data aided symbol timing estimation in space-time coded systems with continuous phase modulation 显示文摘 | Shen Wenli Zhao Minjian Qiu Peiliang | 2009 | European Transactions on Telemmunications2009，20，2： | 1 |
| 10 | An amperometric cholesterol biosensor based on multi - walled carbon nanotubes and organically modi- fied sol - gel / chitosan hybrid composite film显示文摘 | Xuecai Tan Minjian Li Peixiang Cai | 2005 | Analytical Biochemistry2005，337，1： | 1 |
| 11 | Optimal sensor placement for spatial lattice structure based on genetic algorithms 显示文摘 | Liu Wei Gao Weicheng Sun Yi Xu Minjian | 2008 | Journal of Sound and Vibration2008，317，1： | 1 |
| 12 | Difference in Tolerance to Potassium Deficiency between Two Maize Inbred Lines 显示文摘 | CAO MINJIAN YU HAIQIU | 2007 | Plant Production Science2007，10，1： | 1 |
| 13 | An amperometric cholesterol biosensor based on multiwalled carbon nanotubes and organically modified sol-gel/chitosan hybrid composite film显示文摘 | Xuecai Tan Minjian Li Peixiang Cai Lijun Luo Xiaoyong Zou | 2004 | Analytical Biochemistry2004，，1： | 1 |
| 14 | HIV- 1 incidence estimates using IgG - capture BED - enzyme immunoassay from surveillanee sites of injection drug users in three cities of China显示文摘 | Yan Jiang Minjie Wang Minjian Li et d | 2007 | AIDS2007，21，： | 1 |
| 15 | Polymerization Mechanism of MMA in the Presence of 1,1‐Diphenylethylene显示文摘 | Minjian Zhao Dong Chen Yan Shi Wantai Yang Zhifeng Fu | 2013 | Macromol Chem Phys2013，，15： | 1 |
| 16 | Tissue distribution and cancer growth inhibition of magnetic lipoplex-delivered type 1 insulin-like growth factor receptor shRNA in nude mice显示文摘进特定的纸巾的治疗学的基因的指向的交货,以及生物命运的决心和 nanoparticles 的潜在的毒性,为基于基因的治疗仍然是高度相关的挑战。类型 1 像胰岛素的生长因素受体(IGF-1R ) ,重要 oncogene,在肺癌症经常是过去表示的并且调停癌症房间增长以及肿瘤生长。在我们的以前的研究,我们成功地申请了基因交货在一个磁场下面由商业地可得到的 nanoparticles (CombiMAG ) 调停了,它在 vitro 在一根非小的房间肺癌症房间线(A549 ) 压制 IGF-1R 表示。在现在的学习,我们试图经由表示绿色的带 CombiMAG plasmids 调查生物分发和 magnetofection,以及它的潜在的毒性的目标肿瘤抑制荧光灯蛋白质(GFP ) 和在忍受肿瘤的老鼠指向 IGF-1R (pGFPshIGF-1Rs ) 的短发卡 RNA (shRNAs ) 。在各种各样的机关的山峰表示出现了在 transfection 以后的 48 h。经由 magnetofection 的 Transgene 表示比经由 lipofection 是 3 褶层改进。在在注射以后的第 30 天,肿瘤尺寸和对待 CombiMAG 的组的重量(789. | Minjian Kong Xuebiao Li Chunmao Wang Chao Ding Aiqiang Dong Qunjun Duan Zhonghua Shen | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 1 |
| 17 | An amperometric cholesterol biosensor based on multiwalled carbon nanotubes and organically modified sol-gel/chitosan hybrid composite film显示文摘 | Xuecal Tan Minjian Li Peixiang Cai | 2005 | Analytical Biochemistry2005，，337： | 1 |
| 18 | Optimal sensor placement for spatial lattice structure based on genetic algorithms 显示文摘 | Liu Wei Gao Weicheng Sun Yi Xu Minjian | 2008 | Journal of Sound and Vibration2008，317，1： | 1 |
| 19 | Chemical Constit-uents of Viola yedoensis 显示文摘 | Zhou Haiyan Qin Minjian Hong Junli | 2009 | Chin J Nat Med2009，7，4： | 1 |
| 20 | Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization显示文摘Echinacea purpurea modulates tumor progression,but the underlying mechanism is poorly defined.We isolated and purified a novel homogeneous polysaccharide from E.purpurea(EPPA),which was shown to be an arabinogalactan with a mean molecular mass(Mr)of 3.8×10^(4)Da and withα-(1→5)-L-Arabinan as the backbone and a-L-Araf-(1→,→6)-b-D-Galp-(1→,and →4)-α-D-GalpA-(1/as the side chains.Interestingly,oral administration of EPPA suppresses tumor progression in vivo and shapes the immune cell profile(e.g.,facilitating M1 macrophages)in tumor micro-environment by single-cell RNA sequencing(scRNA-seq)analysis. | Wenkai Ren Junfeng Ban Yaoyao Xia Fang Zhou Caihong Yuan Huanhuan Jia Hailan Huang Mingmin Jiang Minjian Liang Zhaodong Li Youyong Yuan Yulong Yin Hong Wu | 2023 | The Innovation2023，4，2： | 1 |
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