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| 1 | Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study显示文摘Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis. | Peipei Jiang Xiaoqiu Tang Huiyan Wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali Hu | 2019 | Science China(Life Sciences)2019，62，12： | 16 |
| 2 | Study on properties of ultra-low dielectric loss mPPO/MTCLT composites prepared by injection molding显示文摘A novel category of polyphenylene oxide/high-impact polystyrene(PPO/HIPS)alloy was used as the polymer matrix(abbreviated as mPPO)and loaded with different volume fractions(0,10,20,30,40,50 vol.%)of MgTiO_(3)-Ca_(0.7)La_(0.2)TiO_(3)(abbreviated as MTCLT)ceramics to prepare composites by injection molding.Its micromorphology,density,dielectric,thermal and mechanical properties were analyzed in detail.The experimental results show that the composites possess a compact microstructure because HIPS increases the fluidity of PPO.Due to the excellent dielectric properties of both mPPO and MTCLT,the composites have an extremely low dielectric loss.The realization of the high ceramic filler fraction greatly limits the thermal expansion of the polymer chain by introducing the interphase,so that the coefficient of thermal expansion of the composite material could be as low as 21.8 ppm/°C.At the same time,the presence of ceramic particles could reinforce the mechanical property of the compos-ites.When the ceramic filler fraction is higher than 20 vol.%,the bending strength of the composite material is around 110 MPa.When the ceramic filler fraction is 40 vol.%,the composite possesses the best comprehensive performance.The dielectric constant is 6.81,the dielectric loss is 0.00104,the thermal expansion coefficient is as low as 25.3 ppm/°C,and the bending strength is 110.4 MPa.Due to its excellent properties,this material can be a good candidate in the field of microwave communication. | Yahan Liu Haiyi Peng Xiaogang Yao Minmin Mao Kaixin Song Huixing Lin | 2022 | Journal of Advanced Dielectrics2022，12，3： | 1 |
| 3 | An Improved Dynamic Modelling for Exploring Ball Bearing Vibrations from Time-Varying Oil Film显示文摘Bearings are key components in rotating machinery,which is widely used in many fields,such as CNC machines,wind turbines and induction machines.The increasingly harsh operation environment can lead to wear and tear on raceways and reduce the precision and reliability of bearing or even machinery.Lubrication could relieve the wear to some degree,which is benefit to prolong the bearing’s life.Thus,investigation on the vibration responses under the influence of oil film is of great significance.However,for mechanism analysis,how to include the oil film into the bearing dynamic model affects the result and efficiency of solution.To address this problem,this study proposed a fast algorithm through load distribution and interpolation when calculating oil film stiffness and thickness during the solution of bearing vibration model.Analysis of oil film on vibration is carried out and a bearing test rig is designed to verify the proposed model.Numerical simulation result shows that rotational speed and load have vital effect on oil film and vibration.The experimental result is consistent with the simulation,which shows that the proposed model has a better performance on modeling bearing vibration and the method of considering oil film is reasonable. | Minmin Xu Zhenzhen Song Xiaoxi Ding Guoxing Li Yimin Shao James Xi Gu | 2022 | Journal of Dynamics, Monitoring and Diagnostics2022，1，2： | 1 |
| 4 | Booster Vaccination in Infancy Reduces the Incidence of Occult HBV Infection in Maternal HBsAg-positive Children显示文摘Background and Aims: Occult HBV infection (OBI) in chil-dren has proven to be associated with their immune re-sponse to hepatitis B vaccine (HepB). This study aimed to investigate the effect of a booster HepB on OBI, which is rarely investigated. Methods: This study enrolled 236 ma-ternal HBsAg-positive children who were followed up annu-ally until 8 years of age and were hepatitis B surface antigen (HBsAg) negative. Of those 100 received a booster HepB be-tween 1 and 3 years of age (booster group), and 136 were never boosted (non-booster group). Serial follow-up data of children and baseline data of their mothers were collected and between-group differences were analyzed. Results: The incidence of OBI varied dynamically during follow-up, with 37.14% (78/210), 19.09% (42/220), 20.85% (44/211), 31.61% (61/193), 8.65% (18/208) and 12.71% (30/236) at 7 months, 1, 2, 3, 4, and 8 years of age. At 8 years of age, the negative conversion rate of HBV DNA in the booster group was significantly higher than that in non-booster group [57.89% (11/19) vs. 30.51% (18/59), p=0.032]. For chil-dren without OBI at 7 months old, the incidence of OBI in booster group was significantly lower than that in non-boost-er group [25.64% (10/39) vs. 67.74% (63/93), p<0.001]. Conclusions: The incidence of OBI in maternal HBsAg-positive children was high, serum HBV DNA in children with OBI was intermittently positive at low levels, and a booster HepB in infancy reduced the incidence of OBI in children with HBsAg-positive mothers. | Yi Li Lili Li Yarong Song Minmin Liu Xiangjun Zhai Zhongping Duan Feng Ding Liguo Zhu Jie Jiang Huaibin Zou Jie Wang Jie Li | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 5 | Presence of organophosphate flame retardants(OPEs)in different functional areas in residential homes in Beijing,China显示文摘The production and application of organophosphate esters(OPEs)have dramatically increased in recent years due to their use as a replacement for brominated flame retardants.In this study,13 OPEs(∑_(13)OPEs)were analyzed in indoor air samples from kitchens and living rooms in 14 residential homes in Beijing,China.The concentrations of ∑_(13)OPEs in kitchen air samples(mean:13 ng/m^(3))were significantly(p<0.05)higher than in living room air samples(5.0 ng/m^(3)).In addition,paired window surface organic film samples were collected and analyzed to investigate film-air partitioning,exhibiting a mean concentration of ∑_(13)OPEs of 4100 ng/m^(2).The congener profiles showed that tris(2-chloroisopropyl)phosphate(TCPP)was the predominant compound in both window film samples(48%)and the corresponding indoor air sample(56%).The estimated daily intakes(EDI)of OPEs via indoor air inhalation were 2.8 and 1.4 ng/kg/day for infants and adults,respectively,both of which are below the reference dose values(RfDs).Overall,these findings indicate that OPEs in the indoor air environment of residential homes in Beijing are not likely to pose a health risk to the general population. | Kun Lv Lu Bai Boyu Song Xindong Ma Minmin Hou Jie Fu Yali Shi Yawei Wang Guibin Jiang | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 6 | Ca^2 + -and Ba^2+ - ligand coordinated unilamellar, mutilamellar, and oligovesicular vesicles 显示文摘 | SONG AIXIN JIA XIANGFENG TENG MINMIN | 2007 | Chem Eur J2007，13，： | 1 |
| 7 | A functional hydrogenase mimic that catalyzes robust H_(2) evolution spontaneously in aqueous environment显示文摘Although great progress has been made in improving hydrogen production,highly efficient catalysts,which are able to produce hydrogen in a fast and steady way at ambient temperature and pressure,are still in large demand.Here,we report a[NiCo]-based hydrogenase mimic,NiCo_(2)O_(4) nanozyme,that can catalyze robust hydrogen evolution spontaneously in water without external energy input at room temperature.This hydrogenase nanozyme facilitates water splitting reaction by forming a three-center Ni-OH-Co bond analogous to the[NiFe]-hydrogenase reaction by using aluminum as electron donor,and realizes hydrogen evolution with a high production rate of 915 L·h^(-1) per gram of nanozymes,which is hundreds of times higher than most of the natural hydrogenase or hydrogenase mimics.Furthermore,the NiCo_(2)O_(4) nanozyme can robustly disrupt the adhesive oxidized layer of aluminum and enable the full consumption of electrons from aluminum.In contrast to the often-expensive synthetic catalysts that rely on rare elements and consume high energy,we envision that this NiCo_(2)O_(4) nanozyme can potentially provide an upgrade for current hydrogen evolution,accelerate the development of scale-up hydrogen production,and generate a clean energy future. | Ningning Song Zhanjun Guo Shuo Wang Yongli Li Yunpeng Liu Meishuai Zou Minmin Liang | 2024 | Nano Research2024，17，5： | 0 |
| 8 | Label-Free,Versatile,Real-Time,and High-Throughput Monitoring of Tyrosine Phosphorylation Based on Reversible Configuration Freeze显示文摘Tyrosine Phosphorylation(pTyr)is a critical and ubiquitous regulation mechanism in biology that plays a central role in controlling intracellular signaling networks.Precise recognition and specific detection of pTyr peptides have been of great importance for both discoveries of disease biomarkers and screening of therapeutic drugs,especially cancers.Here we report a label-free,versatile,realtime,and high-throughput detection strategy for phosphopeptide(PP)based on reversible configuration freeze of a unique hemicyanine-labeled 2-(2′-hydroxyphenyl)-4-methyloxazole(H-HPMO).By taking advantage of the“OFF–ON”transition of fluorescence,H-HPMO–Cu^(2+)complex displays a highly sensitive and selective response to PPs with modified sites on serine,threonine,and tyrosine.Specific recognition of Tyr PPs is achieved by performing a simple logic gate operation and introducing Ca^(2+)interference as an input.This PP detection approach is universal for various peptide sequences and displays high potential in large-scale kinase inhibitor screening,which will promote the development of targeted anticancer drugs. | Yongxin Chang Miao Guo Mengyuan Song Wenjing Sun Dongdong Wang Minmin Li Jixia Wang Yahui Zhang Haijuan Qin Guangyan Qing | 2023 | CCS Chemistry2023，5，6： | 0 |
| 9 | Preparation and luminescent properties of CaF_2:Ln^(3+)(Ln:Er, Er/Yb)/Nafion composite films显示文摘In this work, CaF_2:Ln^(3+)(Ln:Er,Er/Yb)/Nafion composite films were prepared using Nafion as modifications and matrices by dripping method. The composite films were characterized by Fourier transform infrared spectroscopy(FT-IR), X-ray diffraction(XRD) and scanning electron microscopy(SEM). Composite films are transparent and CaF_2:Ln^(3+)(Ln:Er,Er/Yb) nanoparticles are well dispersed in Nafion films.The thicknesses of CaF_2:Er^(3+)/Nafion and CaF_2:Er^(3+),Yb^(3+)/Nafion composite film are about 77 and 73 μm,respectively. The nanoparticles in composite film possess cubic phase. CaF_2:Er^(3+),Yb^(3+)/Nafion composite film has stronger characteristic emission of Er^(3+) around 1530 nm with full width at half-maximum(FWHM) of 73 nm and longer luminescence lifetimes of 22.04 μs(25.03%) and 100.77 μs(74.97%). | Limei Song Jianhua Gao Minmin Liang Xiaojun Li Jiangtao Li Liuchang Wang | 2019 | Journal of Rare Earths2019，37，3： | 0 |
| 10 | Multiscale structural design of MnO_(2)@GO superoxide dismutase nanozyme for protection against antioxidant damage显示文摘Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase(SOD)nanozymes.Here,we reported a novel SOD nanozyme design,with employing graphene oxide(GO)as the framework,andδ-MnO_(2)as the active sites,to mimic the natural Mn-SOD.This MnO_(2)@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology,providing highly specific surface area for·O_(2)−adsorption and confined spaces for subsequent catalytic reactions.Thus,the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%,which is 222.6%and 1605.4%amplification over GO and MnO_(2)nanoparticles,respectively.Additionally,such unique hierarchical structural design endows MnO_(2)@GO with catalytic specificity,which was not present in the individual component(GO or MnO_(2)).This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes. | Yue Yu Yinuo Zhang Yu Wang Wenxing Chen Zhanjun Guo Ningning Song Minmin Liang | 2023 | Nano Research2023，16，8： | 0 |
| 11 | Vaginal Delivery and Breastfeeding Benefit Infant Immune Response to Hepatitis B Vaccine:A Prospective Cohort Study显示文摘Background and Aims:Natural vaginal delivery and breastfeeding favor the development of a strong immune system in infants,and the immune response of infants to vaccines is closely related to their immune system.This large prospective cohort study aimed to explore the effects of delivery and feeding mode on infant’s immune response to hepatitis B vaccine(HepB).Methods:A total of 1,254 infants who completed the whole course of HepB immunization and whose parents were both HBsAg negative were enrolled from infants born in Jinchang City during 2018-2019 by cluster sampling method.Results:Twenty(1.59%)of the 1,254 infants were nonresponders to HepB.Among the other 1,234 infants,10.05%(124/1,234),81.69%(1,008/1,234)and 8.27%(102/1,234)of infants had low,medium,and high responses to HepB,respectively.Logistic regression analysis showed that cesarean section(OR:8.58,95%CI:3.11-23.65,p<0.001)and birth weight<3.18 kg(OR:5.58,95%CI:1.89-16.51,p=0.002)were independent risk factors for infant nonresponse to HepB,and cesarean section(OR:7.63,95%CI:4.64-12.56,p<0.001),formula feeding(OR:4.91,95%CI:1.47-16.45,p=0.001),maternal antiHBs negativity(OR:27.2,95%CI:10.67-69.35,p<0.001),paternal non-response history of HepB(OR:7.86,95%CI:2.22-27.82,p=0.014)and birth weight<3.22 kg(OR:4.00,95%CI:2.43-6.59,p<0.001)were independent risk factors for infant low response to HepB.In cases where birth weight and genetic factors are unmodifiable and maternal anti-HBs effects are controversial,it makes sense to enhance infant response by changing delivery and feeding patterns.Conclusions:Natural vaginal delivery and breastfeeding are beneficial to the infant’s immune response to HepB. | Huiqing Liu Lili Li Yali Li Minmin Liu Yarong Song Feng Ding Xiaoshu Zhang Jie Li | 2023 | Journal of Clinical and Translational Hepatology2023，11，4： | 0 |
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