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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | 9-(2- hydroxyethoxymethyl) guanine activity against viruses of the herpes group显示文摘 | Schaeffer H J Beauehamp L Miranda P de | 1978 | Nature1978，272，： | 1 |
| 3 | Predictive torque control of induction machines based on statespace model显示文摘 | MIRANDA H CORTES P YUz J I | | 0，，06： | 1 |
| 4 | Bioaccumu- lation of chlorinated pesticides and PCBs in the tropi- cal freshwater ftsb Hoplias malabaricus: Histopathologi- cal, physiological, and immunological findings 显示文摘 | Miranda A L Roche H Randi M A F | 2008 | En- vironment International2008，34，7： | 1 |
| 5 | Newinsight on the so-lidification path ofan alloy 625 weld overlay显示文摘 | Silva C C Miranda H C D Motta M F | 2013 | Journal of Materi- als Research and Technology2013，2，3： | 1 |
| 6 | Competing inter- actions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuro- epithelium 显示文摘 | Sathyan P Golden H B Miranda R C | 2007 | J Neurosci2007，27，32： | 1 |
| 7 | 显示文摘 | Miranda C Mansilla H Yanez J | 2013 | J Photochem Photo- biol A : Chem2013，253，： | 1 |
| 8 | Apert syndrome: report of a case with emphasis on craniofacial and genetic feature 显示文摘 | Martelli H Jr Paranaiba LM de Miranda RT | 2008 | Pediatr Dent2008，30，6： | 1 |
| 9 | Antinociceptive and anti - exudative synergism between dexketoprofen and tramad- ol in a model of inflammatory pain in mice 显示文摘 | MIRANDA H F ROMERO M A PUIG M M | 2012 | Fundam Clin Pharmacol2012，26，3： | 1 |
| 10 | 9- (2-hydroxymethyl) guanine activity against viruses of the herpes group显示文摘 | Schaefer H J Beauchamp L de Miranda P | 1978 | Nature1978，272，5654： | 1 |
| 11 | Silica-alumina-supported acidic molybdenum catalysts-TPR and XRD显示文摘 | RAJAGOPAL S MARINI H J MARZARI J A MIRANDA R | 1994 | J Catal1994，147，2： | 1 |
| 12 | Vacuum pyrolysis of commingled plastics containing PVC II: product analysis显示文摘 | Miranda R Pakdel H Roy C | 2001 | Polymer Degradation and Stability2001，73，1： | 1 |
| 13 | Vacuum pyrolysis of PVC Ⅱ:product analysis显示文摘 | Miranda R Pakdel H Roy C | 1999 | Polymer Degradation and Stability1999，66，1： | 1 |
| 14 | Breast implant-associated anaplastic large-cell lymphoma:long-term follow-up of 60patients显示文摘 | Miranda R N Aladily T N Prince H M | 2014 | J Clin Oncol2014，32，2： | 1 |
| 15 | O3:K6 serotype of Vibrio parahacmolyticus identical to the global pandemic clone associated with diarrhea in Peru显示文摘 | Gil AI Miranda H Prada A | 2007 | Int J Infect Dis2007，11，： | 1 |
| 16 | Insulin oversecretion in MSG-obese rats is related to alterations in cholinergic muscarinic receptor subtypes in pancreatic islets 显示文摘 | MIRANDA R A AGOSTINHO A R TREVENZOLI I H | 2014 | Cell Physiol Biochem2014，33，4： | 1 |
| 17 | Mannan-binding lectin enhances susceptibility to visceral leishmaniasis 显示文摘 | de Miranda SI Costa C Krieger H | 2001 | Infect Immun2001，69，8： | 1 |
| 18 | physical dependence comparison between morphine and tramadol显示文摘 | Miranda H F Pinardi G Antinociception | 1998 | Pharm Biochem Behav1998，61，4： | 1 |
| 19 | The diagnostic importance of species specific and cross-reactive components of Taenia solium,Echinococcus granulosus,and Hymenolepis nana显示文摘 | Montenegro T Gilman RH Castillo R Tsang V Brandt J Guevara A Sanabria H Verastegui M Sterling C Miranda E 1994 | 1994 | Rev Inst Med Trop Sao Paulo1994，36，4： | 1 |
| 20 | Predictive torque control of induction machines based on state-space models显示文摘 | Miranda H Cortes P Yuz J I | 2009 | IEEE Transactions on Industrial Electronics2009，56，6： | 1 |
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