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| 1 | Fifteen years of bone marrow mononuclear cell therapy in acute myocardial infarction显示文摘In spite of modern treatment, acute myocardial infarction(AMI) still carries significant morbidity and mortality worldwide. Even though standard of care therapy improves symptoms and also long-term prognosis of patients with AMI, it does not solve the critical issue, specifically the permanent damage of cardiomyocytes. As a result, a complex process occurs, namely cardiac remodeling, which leads to alterations in cardiac size, shape and function. This is what has driven the quest for unconventional therapeutic strategies aiming to regenerate the injured cardiac and vascular tissue. One of the latest breakthroughs in this regard is stem cell(SC) therapy. Based on favorable data obtained in experimental studies, therapeutic effectiveness of this innovative therapy has been investigated in clinical settings. Of various cell types used in the clinic, autologous bone marrow derived SCs were the first used to treat an AMI patient, 15 years ago. Since then, we have witnessed an increasing body of data as regards this cutting-edge therapy. Although feasibility and safety of SC transplant have been clearly proved, it's efficacy is still under dispute. Conducted studies and meta-analysis reported conflicting results, but there is hope for conclusive answer to be provided by the largest ongoing trial designed to demonstrate whether this treatment saves lives. In the meantime, strategies to enhance the SCs regenerative potential have been applied and/or suggested, position papers and recommendations have been published. But what have we learned so far and how can we properly use the knowledge gained? This review will analytically discuss each of the above topics, summarizing the current state of knowledge in the field. | Miruna Mihaela Micheu Maria Dorobantu | 2017 | World Journal of Stem Cells2017，9，4： | 4 |
| 2 | Bacterial diversity of soils assessed by DGGE, T-RFLP and SSCP fingerprints of PCR-amplified 16S rRNA gene fragments: Do the different methods provide similar results?显示文摘 | Kornelia Smalla Miruna Oros-Sichler Annett Milling Holger Heuer Susanne Baumgarte Regina Becker Gabriele Neuber Siegfried Kropf Andreas Ulrich Christoph C. Tebbe | 2007 | Journal of Microbiological Methods2007，，3： | 1 |
| 3 | The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial显示文摘 | Victor Novack Miruna Eisinger Amit Frenkel Marius Terblanche Neill K. J. Adhikari Amos Douvdevani Doron Amichay Yaniv Almog | 2009 | Intensive Care Medicine2009，，7： | 1 |
| 4 | Bacterial diversity ofsoil assessed by DGGE,T-RFLP and SSCP fingerprints of PCRamplified16S rRNA gene fragments: Do the different methodsprovide similar results 显示文摘 | Kornelia S Miruna OS Annett M | 2007 | Journal of Microbiological Methods2007，69，3： | 1 |
| 5 | A new seminested PCR protocol to amplify large 18S rRNA gene fragments for PCR-DGGE analysis of soil fungal communities 显示文摘 | Miruna O S Newton C M Gabriele N | 2006 | J Microbiol Methods2006，65，1： | 1 |
| 6 | Propofol-imprinted membranes with potential applications in biosensors显示文摘 | MIRUNA P PETER N | 2004 | Analytic Chimica Acta2004，504，： | 1 |
| 7 | Stem/progenitor cells and obstructive sleep apnea syndrome - new insights for clinical applications显示文摘Obstructive sleep apnea syndrome(OSAS) is a widespread disorder, characterized by recurrent upper airway obstruction during sleep, mostly as a result of complete or partial pharyngeal obstruction. Due to the occurrence of frequent and regular hypoxic events, patients with OSAS are at increased risk of cardiovascular disease, stroke, metabolic disorders, occupational errors, motor vehicle accidents and even death. Thus, OSAS has severe consequences and represents a significant economic burden. However, some of the consequences, as well as their costs can be reduced with appropriate detection and treatment. In this context, the recent advances that were made in stem cell biology knowledge and stem cell- based technologies hold a great promise for various medical conditions, including respiratory diseases. However, the investigation of the role of stem cells in OSAS is still recent and rather limited, requiring further studies, both in animal models and humans. The goal of this review is to summarize the current state of knowledge regarding both lung resident as well as circulating stem/progenitor cells and discuss existing controversies in the field in order to identify future research directions for clinical applications in OSAS. Also, the paper highlights the requisite for inter-institutional, multi-disciplinary research collaborations in order to achieve breakthrough results in the field. | Miruna Mihaela Micheu Ana-Maria Rosca Oana-Claudia Deleanu | 2016 | World Journal of Stem Cells2016，8，10： | 1 |
| 8 | Bacterial diversi- ty of soils assessed by DGGE,T- RFLP and SSCP finger- prints of PCR-amplified 16S rRNA gene fragments : Do the different methods provide similar results 显示文摘 | Kornelia S Miruna O S Annett M | 2007 | Journal of Microbiological Methods2007，69，3： | 1 |
| 9 | Bacterial diversity of soils assessed by DGGE, T-RFLP and SSCP fingerprints of PCR-amplified 16 S rRNA gene fragments: Do the different methods provide similar results? 显示文摘 | KORNELIA S MIRUNA O S ANNETF M | 2007 | J Microb Meth2007，69，： | 1 |
| 10 | Acute myocardial injury in patients with COVID-19:Possible mechanisms and clinical implications显示文摘Severe acute respiratory syndrome coronavirus 2 infection affects not only the lungs,but also the cardiovascular system,having a major impact on patients’outcomes.Myocardial injury(MI)occurs in the context of coronavirus infectious disease 2019(COVID-19)and is associated with a higher risk of severe clinical outcome and mortality.COVID-19-related MI can have various clinical manifestations,of which the main ones are myocarditis,stress cardiomyopathy,acute coronary syndrome,and pulmonary embolism.The exact mechanisms of how MI occurs in these patients are not yet fully known.Direct injury,through direct viral myocardial invasion,and indirect injury,through interaction with angiotensin I converting enzyme 2,increased inflammation,and thrombocyte and endothelial dysfunction,could be involved in acute MI in patients with COVID-19.A better understanding of these multiple potential mechanisms may help to develop new targeted therapeutic strategies.The purpose of this review is to provide the current understanding of the potential mechanisms involved in MI induced by COVID-19 and to discuss the current progress in the therapeutic strategies. | Iulia Rusu Malina Turlacu Miruna Mihaela Micheu | 2022 | World Journal of Clinical Cases2022，10，3： | 1 |
| 11 | Enhance Stability and in vitro Cell Response to a Bioinspired Coating on Zr Alloy with Increasing Chitosan Content显示文摘现在的纸的目的是描绘 bioinspired chitosan (CS )+ hydroxyapatite (哈) 有有钛的锆合金上的各种各样的部件比率的涂层。涂层被英尺红外描绘, SEM,吸水 / 恐水病的平衡,坚持,粗糙,电气化学的稳定性并且在 vitro 房间反应。包括 potentiodynamic 极化曲线和电气化学的阻抗光谱学,电气化学的测试在正常盐的生理的答案被执行。MC3T3-E1 造骨细胞的房间生存能力,喂奶脱氢酶,氮的氧化物,和反应的氧种类(ROS ) 层次,以及肌动朊细胞骨架形态学,在 vitro 测试作为生物被评估。结果在上在 vitro 房间反应,为所有样品的显示的好房间膜正直和生存能力,而是一个增加的房间数,减少的 ROS 水平和一个更好的细胞骨架组织与一个更高的 CS 内容为样品被注意。有最高的 CS 集中的涂层基于试验性的数据显示了最好的性能。最高吸水的特性,最高的抵抗到腐蚀和最好的 biocompatibility 也在织物工程为 bioapplications 推荐这涂层。 | Daniela Ionita Maria Vardaki Miruna S. Stan Anca Dinischiotu Ioana Demetrescu | 2017 | Journal of Bionic Engineering2017，14，3： | 1 |
| 12 | Bacterial diversity of soils assessed by DGGE,T-RFLP and SSCP fingerprints of PCR-amplified 16S rRNA gene fragments:Do the different methods provide similar results显示文摘 | Kornelia Smalla Miruna Oros-Sichler Annett Milling | 2007 | Journal of Microbiological Methods2007，69，： | 1 |
| 13 | Moving forward on the pathway of cell-based therapies in ischemic heart disease and heart failure-time for new recommendations?显示文摘Although substantial advances have been made in treating ischemic heart disease and subsequent heart failure, the overall morbidity and mortality from these conditions remain high. Stem cell-based therapy has emerged as a promising approach for prompting cardiac rejuvenation. Various cell types have been tested in the clinical arena, proving consistent safety results. As for efficiency outcomes, contradictory findings have been reported, partly due to inconsistency in study protocols but also due to poor survival, engraftment and differentiation of transplanted cells in the hostile milieu of the ischemic host tissue. Studies have varied in terms of route of delivery, type and dose of implanted stem cells, patient selection and randomization, and assessment of therapeutic effect. Founded on the main achievements and challenges within almost 20 years of research, a number of official documents have been published by leading experts in the field. Core recommendations have focused on developing and optimizing effective strategies to enrich cell retention and their regenerative potential. Issued consensus and position papers have stemmed from an unmet need to provide a harmonized framework for future research, resulting in improved therapeutic application of cell-based therapies for cardiac regeneration and repair. | Miruna Mihaela Micheu | 2019 | World Journal of Stem Cells2019，11，8： | 1 |
| 14 | The impact of story bound entrepreneurial role models on self-efficacy and entrepreneurial intention显示文摘 | Eric Michael Laviolette Miruna Radu Lefebvre Olivier Brunel | 2012 | International Journal of Entrepreneurial Behaviour & Research2012，，6： | 1 |
| 15 | Propofol-imprinted membranes with potential applications in biosensors显示文摘 | Miruna P Peter N S Christian J C | 2004 | Analytica Chimica Acta2004，，504： | 1 |
| 16 | The effects of statin therapy on inflammatory a randomize double-blind placebo controled clinical trial显示文摘 | Victor N Miruna E Amit F | 2009 | Intensive Care Med2009，35，7： | 1 |
| 17 | COVID-19 impact on the liver显示文摘The coronavirus disease 2019(COVID-19)pandemic imposed arestructuring of global health systems by rethinking spaces used for the care of these patients and the additions of intensive care,infectious diseases and pneumology departments.This paper provides evidence on the presence of severe acute respiratory syndrome coronavirus 2 in hepatocytes and its direct cytopathic activity,as well as the degree of liver damage due to drug toxicity,inflammation and hypoxia in COVID-19.A review of clinical trials has quantified liver damage through both pathology and biochemistry studies.Additionally,we briefly present the results of a study conducted in our clinic on 849 patients admitted for COVID-19 treatment,of which 31 patients had pre-existing chronic liver disease and 388 patients had values above the normal limit for alanine aminotransferase,aspartate aminotransferase,and total bilirubin.It was observed that patients with abnormal liver tests were significantly statistically older,had more comorbidities and had a higher percentage of unfavourable evolution(death or transfer to intensive care).The conclusion of this paper is that the main causes of liver damage are direct viral aggression,coagulation dysfunction and endothelial damage,and patients with impaired liver function develop more severe forms of COVID-19 which requires special care by a multidisciplinary team that includes a hepatologist. | Liliana Baroiu Caterina Dumitru Alina Iancu Ana-Cristina Leșe Miruna Drăgănescu Nicușor Baroiu Lucreția Anghel | 2021 | World Journal of Clinical Cases2021，9，16： | 0 |
| 18 | Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease显示文摘Despite optimal interventional and medical therapy, ischemic heart disease is still an important cause of morbidity and mortality worldwide. Although not included in standard of care rehabilitation, stem cell therapy(SCT) could be a solution for prompting cardiac regeneration. Multiple studies have been published from the beginning of SCT until now, but overall no unanimous conclusion could be drawn in part due to the lack of appropriate endpoints. In order to appreciate the impact of SCT, multiple markers from different categories should be considered: Structural, biological, functional, physiological, but also major adverse cardiac events or quality of life. Imaging end-points are among the most used-especially left ventricle ejection fraction(LVEF) measured through different methods. Other imaging parameters are infarct size, myocardial viability and perfusion. The impact of SCT on all of the aforementioned end-points is controversial and debatable. 2 D-echocardiography is widely exploited, but new approaches such as tissue Doppler, strain/strain rate or 3 D-echocardiography are more accurate, especially since the latter one is comparable with the MRI gold standard estimation of LVEF. Apart from the objective parameters, there are also patient-centered evaluations to reveal the benefits of SCT, such as quality of life and performance status, the most valuable from the patient point of view. Emerging parameters investigating molecular pathways such as non-coding RNAs or inflammation cytokines have a high potential as prognostic factors. Due to the disadvantages of current techniques, new imaging methods with labelled cells tracked along their lifetime seem promising, but until now only pre-clinical trials have been conducted in humans. Overall, SCT is characterized by high heterogeneity not only in preparation, administration and type of cells, but also in quantification of therapy effects. | Maria Dorobantu Nicoleta-Monica Popa-Fotea Mihaela Popa Iulia Rusu Miruna Mihaela Micheu | 2017 | World Journal of Stem Cells2017，9，12： | 0 |
| 19 | 艾克斯普罗旺斯音乐学院显示文摘本案是由日本著名建筑师隈研吾设计的位于法国南部的艾克斯普罗旺斯音乐学院,其前身成立于1849年,是法国历史最悠久的音乐学院之一。学院共占地3,366平方米,总楼层面积为7,395平方米,礼堂可容纳500人。钢铝复合板结构和褶皱的墙壁是艾克斯普罗旺斯音乐学院最大的设计特色。
该项目是音乐学校、音乐厅和各类其他设施的综合建筑。由于该地区的地势存在很大差异,其相邻地区的地势也颇不平坦。为了解决这个问题,设计师团队选择铝材作为构成整个外墙的单一材料,并对其进行了局部折叠。 | 隈研吾 Kongo Kuma Dlogo Loooz Arahuetes Miruna Constantnescu Natalia Sanz Elise Fauquenbergue Mlguel Orelana Junkl Wakuda Tristan Zelic Magnus Casselorant loanna Angelldou Yukl lto Emllle Bret Majd Katr Roman Martin Dennis Cheung Chao Chen Roand Halbe 姜敏华 | 2014 | 现代装饰2014，0，10： | 0 |
| 20 | Patient-specific induced pluripotent stem cells as“disease-in-adish”models for inherited cardiomyopathies and channelopathies–15 years of research显示文摘Among inherited cardiac conditions,a special place is kept by cardiomyopathies(CMPs)and channelopathies(CNPs),which pose a substantial healthcare burden due to the complexity of the therapeutic management and cause early mortality.Like other inherited cardiac conditions,genetic CMPs and CNPs exhibit incomplete penetrance and variable expressivity even within carriers of the same pathogenic deoxyribonucleic acid variant,challenging our understanding of the underlying pathogenic mechanisms.Until recently,the lack of accurate physiological preclinical models hindered the investigation of fundamental cellular and molecular mechanisms.The advent of induced pluripotent stem cell(iPSC)technology,along with advances in gene editing,offered unprecedented opportunities to explore hereditary CMPs and CNPs.Hallmark features of iPSCs include the ability to differentiate into unlimited numbers of cells from any of the three germ layers,genetic identity with the subject from whom they were derived,and ease of gene editing,all of which were used to generate“disease-in-a-dish”models of monogenic cardiac conditions.Functionally,iPSC-derived cardiomyocytes that faithfully recapitulate the patient-specific phenotype,allowed the study of disease mechanisms in an individual-/allele-specific manner,as well as the customization of therapeutic regimen.This review provides a synopsis of the most important iPSC-based models of CMPs and CNPs and the potential use for modeling disease mechanisms,personalized therapy and deoxyribonucleic acid variant functional annotation. | Miruna Mihaela Micheu Ana-Maria Rosca | 2021 | World Journal of Stem Cells2021，13，4： | 0 |
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