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| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design显示文摘 | Matthew H. G. Katz Robert Marsh Joseph M. Herman Qian Shi Eric Collison Alan P. Venook Hedy L. Kindler Steven R. Alberts Philip Philip Andrew M. Lowy Peter W. T. Pisters Mitchell C. Posner Jordan D. Berlin Syed A. Ahmad | 2013 | Annals of Surgical Oncology2013，，8： | 4 |
| 3 | Partial growth-hormone insensitivity: The role of growth-hormone receptor mutations in idiopathic short stature显示文摘 | Audrey D. Goddard Patrick Dowd Steven Chernausek Mitchell Geffner Joseph Gertner Raymond Hintz Nancy Hopwood Selna Kaplan Leslie Plotnick Alan Rogol Robert Rosenfield Paul Saenger Nellie Mauras Richard Hershkopf Morris Angulo Kenneth Attie | 1997 | The Journal of Pediatrics1997，，1： | 2 |
| 4 | Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors显示文摘 | Rafael A. Ibarra Daniel Rojas Laura Snyder Min Yao Jeffrey Fabien Michael Milano Alan Katz Karyn Goodman Kevin Stephans Galal El-Gazzaz Federico Aucejo Charles Miller John Fung Simon Lo Mitchell Machtay Juan R. Sanabria | 2012 | Acta Oncologica2012，，5： | 2 |
| 5 | A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis显示文摘 | Arun J. Sanyal Pouneh S. Mofrad Melissa J. Contos Carol Sargeant Velimir A. Luketic Richard K. Sterling R. Todd Stravitz Mitchell L. Shiffman John Clore Alan S. Mills | 2004 | Clinical Gastroenterology and Hepatology2004，，12： | 1 |
| 6 | Mucinous carcinoma—Just another colon cancer?显示文摘 | Dr. Johnny B. Green M.D. Alan E. Timmcke M.D. William T. Mitchell M.D. Terrel C. Hicks M.D. J. Byron Gathright M.D. John E. Ray M.D | 1993 | Diseases of the Colon & Rectum1993，，1： | 1 |
| 7 | Mucinous carcinoma—Just another colon cancer?显示文摘 | Dr. Johnny B. Green M.D. Alan E. Timmcke M.D. William T. Mitchell M.D. Terrel C. Hicks M.D. J. Byron Gathright M.D. John E. Ray M.D | 1993 | Diseases of the Colon & Rectum1993，，1： | 1 |
| 8 | A simple black box model for erbium-doped fiber amplifiers 显示文摘 | Zhang Xiupu Mitchell Alan | 2000 | IEEE Photon Technol Lett2000，12，1： | 1 |
| 9 | SPECIAL ARTICLE显示文摘 | Jian-ming Li Robert S. Podolsky Michael J. Rohrer Bruce S. Cutler Mitchell T. Massie Marc R. Barnard Alan D. Michelson | 1996 | Journal of Surgical Research1996，，2： | 1 |
| 10 | Stimulation of the P2X 7 receptor kills rat retinal ganglion cells in vivo显示文摘 | Huiling Hu Wennan Lu Mei Zhang Xiulan Zhang Arthur J. Argall Shaun Patel Ga Eun Lee Yong-Chul Kim Kenneth A. Jacobson Alan M. Laties Claire H. Mitchell | 2010 | Experimental Eye Research2010，，3： | 1 |
| 11 | Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors显示文摘 | Rafael A. Ibarra Daniel Rojas Laura Snyder Min Yao Jeffrey Fabien Michael Milano Alan Katz Karyn Goodman Kevin Stephans Galal El-Gazzaz Federico Aucejo Charles Miller John Fung Simon Lo Mitchell Machtay Juan R. Sanabria | 2012 | Acta Oncologica2012，，5： | 1 |
| 12 | Simulation of infrared backgrounds using two-dimensional models 显示文摘 | James A Cadzow D Mitchell Wilkes Richard Alan Peters II | 1991 | Proceedings of SPIE1991，1468，： | 1 |
| 13 | A simple black box model for erbium-doped fiber amplifiers 显示文摘 | ZHANG Xiu-pu Mitchell Alan | 2000 | IEEE Photonics Technology Letters2000，，1： | 1 |
| 14 | The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response显示文摘 | Joshua P. Lewis Richard B. Horenstein Kathleen Ryan Jeffrey R. O’Connell Quince Gibson Braxton D. Mitchell Keith Tanner Sumbul Chai Kevin P. Bliden Udaya S. Tantry Cody J. Peer William D. Figg Shawn D. Spencer Michael A. Pacanowski Paul A. Gurbel Alan R. | 2013 | Pharmacogenetics and Genomics2013，，1： | 1 |
| 15 | INFLUENCE OF THE Rh (D) BLOOD GROUP SYSTEM ON GRAFT SURVIVAL IN RENAL TRANSPLANTATION显示文摘 | Christopher F. Bryan Stanley I. Mitchell Hung Mo Lin Paul W. Nelson Charles F. Shield Alan M. Luger George E. Pierce Gilbert Ross Bradley A. Warady Mark I. Aeder Thomas S. Helling Michael D. Landreneau Kevin M. Harrell | 1998 | Transplantation1998，，4： | 1 |
| 16 | Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1显示文摘 | Charles D. Howell Alexis Gorden Kathleen A. Ryan Alexander J. Thompson Chadi Ibrahim Michael Fried Nezam H. Afdhal John G. McHutchison Kevin V. Shianna David B. Goldstein Alan R. Shuldiner Braxton D. Mitchell | 2012 | Journal of Hepatology2012，，3： | 1 |
| 17 | Non-responsive celiac disease in children on a gluten free diet显示文摘BACKGROUND Non-responsive celiac disease(NRCD) is defined as the persistence of symptoms in individuals with celiac disease(CeD) despite being on a gluten-free diet(GFD). There is scant literature about NRCD in the pediatric population.AIM To determine the incidence, clinical characteristics and underlying causes of NRCD in children.METHODS Retrospective cohort study performed at Boston Children’s Hospital(BCH). Children < 18 years diagnosed with CeD by positive serology and duodenal biopsies compatible with Marsh Ⅲ histology between 2008 and 2012 were identified in the BCH’s Celiac Disease Program database. Medical records were longitudinally reviewed from the time of diagnosis through September 2015. NRCD was defined as persistent symptoms at 6 mo after the initiation of a GFD and causes of NRCD as well as symptom evolution were detailed. The children without symptoms at 6 mo(responders) were compared with the NRCD group. Additionally, presenting signs and symptoms at the time of diagnosis of CeD among the responders and NRCD patients were collected and compared to identify any potential predictors for NRCD at 6 mo of GFD therapy.RESULTS Six hundred and sixteen children were included. Ninety-one(15%) met criteria for NRCD. Most were female(77%). Abdominal pain [odds ratio(OR) 1.8 95% confidence interval(CI) 1.1-2.9], constipation(OR 3.1 95%CI 1.9-4.9) and absence of abdominal distension(OR for abdominal distension 0.4 95%CI 0.1-0.98) at diagnosis were associated with NRCD. NRCD was attributed to a wide variety of diagnoses with gluten exposure(30%) and constipation(20%) being the most common causes. Other causes for NRCD included lactose intolerance(9%), gastroesophageal reflux(8%), functional abdominal pain(7%), irritable bowel syndrome(3%), depression/anxiety(3%), eosinophilic esophagitis(2%), food allergy(1%), eating disorder(1%), gastric ulcer with Helicobacter pylori(1%), lymphocytic colitis(1%), aerophagia(1%) and undetermined(13%). 64% of children with NRCD improved on follow-up.CONCLUSION NRCD after ≥ 6 mo GFD is frequent among children, especially females, and is associated with initial presenting symptoms of constipation and/or abdominal pain. Gluten exposure is the most frequent cause. | Gopal Veeraraghavan Amelie Therrien Maya Degroote Allison McKeown Paul D Mitchell Jocelyn A Silvester Daniel A Leffler Alan M Leichtner Ciaran P Kelly Dascha C Weir | 2021 | World Journal of Gastroenterology2021，27，13： | 0 |
| 18 | A call for international research on COVID-19-induced brain dysfunctions显示文摘The COVID-19 pandemic, still raging worldwide, imposes staggering human and economic costs. These will only increase as many convalescent patients suffer consequences for many years.Though the virus can target multiple organ systems, we focus on COVID-19-induced brain dysfunction(CIBD). | Pedro A.Valdes-Sosa Alan CEvans Mitchell JValdes-Sosa Mu-ming Poo | 2021 | National Science Review2021，8，12： | 0 |
| 19 | Role of arthropod communities in bioenergy crop litter decomposition显示文摘期望发生相遇的广泛的陆地使用变换为 bioenergy 化工物品要求生产将多半在 agroecosystem 生物多样性和生态系统服务上有普遍影响,包括碳隐遁。尽管节肢动物 detritivores 被知道贡献崽分解,因此,在许多骑车的能量流动和营养素种社区,他们在 bioenergy 化工物品社区的重要性还没被估计了。我们拿了确定的试验性的研究崽团损失并且在三 bioenergy 化工物品 cropsmiscanthus (错误眼角 x giganteus ) 的当面的滋养的骑车和这些有机体的缺席的率, switchgrass (Panicum virgatum ) ,和一个种的大草原社区。全面节肢动物丰富和崽分解率在所有三个社区是类似的。尽管有在经由杀虫药剂申请的试验性的阴谋的节肢动物的有效减小,崽分解率,沥滤的无机的氮,和 carbonnitrogen 比率没在控制之间显著地不同(与节肢动物) 并且处理(没有节肢动物) 在任何三种社区类型的阴谋。我们的调查结果建议在动物区系的作文与 bioenergy 化工物品庄稼的普遍采纳联系了的节肢动物的变化不能与深刻地改变的调停节肢动物的崽分解和滋养的版本被联系。 | Arthur R. Zangerl Saber Miresmailli Paul Nabity Allen Lawrance Alan Yanahan Corey A. Mitchell Kristina J. Anderson-Teixeira Mark B. David May R. Berenbaum Evan H. DeLucia | 2013 | Insect Science2013，20，5： | 0 |
| 20 | 温馨与高雅并存——多伦多四季旗舰酒店显示文摘项目概况多伦多四季酒店位于加拿大多伦多市约克维尔区的购物和餐饮中心,是一栋豪华五星级度假酒店和公寓混合使用的地标性建筑。它高55层,由位于地段西南角的豪华公寓酒店大楼和位于东北角的物业大楼组成,酒店大楼中包括了酒店21 7间客房、42间套房、四季餐厅、酒吧和个人公寓。从大楼北边延伸出一个八层高的小楼.设有宴会厅会议室、跨两层的水疗中心、健身房和游泳池。 | Alan Mitchell 王小静 | 2014 | 设计家2014，，3： | 0 |
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