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| 1 | SMALL ORGAN SIZE 1 and SMALL ORGAN SIZE 2/DWARF AND LOW-TILLERING Form aComplex to Integrate Auxin and Brassinosteroid Signaling in Rice显示文摘尽管植物生长素和 brassinosteroid (BR ) synergistically 控制各种各样的植物回答,位于 auxin-BR 串音下面的分子的机制很好没被理解。我们以前识别了 SMOS1,一个调整植物生长素的 APETALA2 类型抄写因素,作为小机关的原因的基因缩放 1 (smos1 ) 被各种各样的机关的一种减少的最后的尺寸在米饭描绘的异种。在这研究,我们识别了另一 smos 异种, smos2,哪个表演与 smos1 难区分的显型。SMOS2 与以前报导的矮子和 LOW-TILLERING (DLT ) 相同,它编码涉及 BR 发信号的 GRAS 蛋白质。SMOS1 和 SMOS2/DLT 身体上交往合作地在酵母并且在米饭原子核提高 transcriptional transactivation 活动。一致地, OsPHI-1 的表示, SMOS1 的一个直接目标,当 SMOS1 和 SMOS2/DLT 蛋白质两个都是在米饭房间的现在时,仅仅是 upregulated。一起拿,我们的结果建议 SMOS1 和 SMOS2/DLT 在在米饭表明串音的 auxin-BR 上形成重点建筑群。 | Ko Hirano Hideki Yoshida Koichiro Aya Mayuko Kawamura Makoto Hayashi Tokunori Hobo Karma Sato-lzawa Hidemi Kitano Miyako Ueguchi-Tanaka Makoto Matsuoka | 2017 | Molecular Plant2017，10，4： | 20 |
| 2 | Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism显示文摘植物 metabolomics 作为一个强大的工具发展了检验基因功能并且获得更深的卓见进植物房间的生理学。在这研究,我们屏蔽了 Arabidopsis 线 overexpressing 米饭全身(FL ) 用煤气的 chromatographytime-of-flight 团 spectrometry (GCTOF/MS ) 的 cDNAs (米饭狐狸 Arabidopsis 线) 基于技术识别引起了新陈代谢的变化的米饭基因。这个屏蔽系统允许显示出改变的代谢物侧面的候选人线的快、可靠的鉴定。我们执行了怀有 Arabidopsis 的侧面的机关边界(高球) 领域(LBD )/Asymmetric 象 Leaves2 一样(ASL ) 基因的米饭 ortholog 的 FL cDNA 的一根米饭狐狸 Arabidopsis 线的 metabolomic 和 transcriptomic 分析, At-LBD37/ASL39。调查米饭狐狸 Arabidopsis 线在与氮新陈代谢有关的代谢物的层次显示出突出的变化。象从 Arabidopsis At-LBD37/ASL39-overexpressor 植物的代谢物分析的结果一样的 transcriptomic 数据与这些调查结果一致。而且, Os-LBD37/ASL39-overexpressing 米饭植物的 metabolomic 和 transcriptomic 分析显示 Os-LBD37/ASL39 在米饭与与氮新陈代谢有关的过程被联系。因此,一个基于 metabolomics 的屏蔽方法的联合和一条 gain-of-function 途径为在 Arabidopsis 和米饭的新奇基因的快速的描述是有用的。 | Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa Keiko Matsui Hirofumi Kuroda Yoko Horii Yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika Minami Matsui Kazuki Saito | 2010 | Molecular Plant2010，3，1： | 15 |
| 3 | Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice显示文摘AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and proliferation.METHODS:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) mice.RESULTS:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO mice.KO mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal tumors.In addition,KO mice showed higher incidence and frequency of liver tumors after AOM treatment.Thirteen percent of WT mice developed liver tumors,and these WT mice had only a single tumor.In contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple tumors.CONCLUSION:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in mice.This study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects. | Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura | 2008 | World Journal of Gastroenterology2008，14，42： | 12 |
| 4 | Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial显示文摘 | Tetsuya Mitsudomi Satoshi Morita Yasushi Yatabe Shunichi Negoro Isamu Okamoto Junji Tsurutani Takashi Seto Miyako Satouchi Hirohito Tada Tomonori Hirashima Kazuhiro Asami Nobuyuki Katakami Minoru Takada Hiroshige Yoshioka Kazuhiko Shibata Shinzoh Kudoh Ei | 2010 | Lancet Oncology2010，，2： | 8 |
| 5 | Deciphering Starch Quality of Rice Kernels Using Metabolite Profiling and Pedigree Network Analysis显示文摘米饭谷物的生理的性质对消费者立即明显。米饭差异研究集合的高范围的 metabolomic 描述预言了在丰满的酸和类脂化合物之间的否定关联层次和直链淀粉 / 总数淀粉比率(直链淀粉比率) ,而是为这的原因是不清楚的。为了在米饭核,淀粉小粒结构,直链淀粉比率,和代谢物的视觉显型之中获得新卓见进关系,变化,我们与各种各样的直链淀粉比率和二猛烈异种调查了五装饰用的梨树栽培变种的代谢物变化( e1 ,淀粉 synthase IIIa ( SSIIIa )缺乏的异种和 SSIIIa/starch 分叉的酶()双大美人异种 4019 )由使用集体 基于spectrometry 的 metabolomics 技术。扫描电子显微镜学清楚地证明二异种有不平常的淀粉小粒结构。,有高直链淀粉比率(Hoshiyutaka 和 Yumetoiro ) 的二栽培变种的 metabolomic 作文展出了类似的模式双大美人异种,它有极其高的直链淀粉比率,不同。栽培变种和异种的瑞斯家谱网络分析在在日本繁殖的米饭提供了卓见进在新陈代谢特点的性质和他们的内在的基因基础之间的协会。多维的可伸缩分析表明 Hoshiyutaka 和 Yumetoiro 栽培变种是象 Indica 一样,然而,他们作为装饰用的梨树 subpopulations 被分类。探索 metabolomic 特点是跟随米饭的一个强大的方法基因踪迹和繁殖历史。 | Miyako Kusano Atsushi Fukushima Naoko Fujita Yozo Okazaki Makoto Kobayashi Naoko Fujita Oitome Kaworu Ebana Kazuki Saito | 2012 | Molecular Plant2012，5，2： | 4 |
| 6 | OsIDD2, a zinc finger and INDETERMINATE DOMAIN protein, regulates secondary cell wall formation显示文摘Previously, we found 123 transcription factors(TFs) as candidate regulators of secondary cell wall(SCW)formation in rice by using phylogenetic and co-expression network analyses. Among them, we examined in this work the role of OsIDD_2, a zinc finger and indeterminate domain(IDD) family TF. Its overexpressors showed dwarfism, fragile leaves, and decreased lignin content, which are typical phenotypes of plants defective in SCW formation, whereas its knockout plants showed slightly increased lignin content.The RNA-seq and quantitative reverse transcription polymerase chain reaction analyses confirmed that some lignin biosynthetic genes were downregulated in the OsIDD_2-overexpressing plants, and revealed the same case for other genes involved in cellulose synthesis and sucrose metabolism. The transient expression assay using rice protoplasts revealed that OsIDD_2 negatively regulates the transcription of genes involved in lignin biosynthesis, cinnamyl alcohol dehydrogenase 2 and 3(CAD_2 and 3), and sucrose metabolism, sucrose synthase 5(SUS_5), whereas an Alpha Screen assay, which can detect the interaction between TFs and their target DNA sequences, directly confirmed the interaction between OsIDD_2 and the target sequences located in the promoter regions of CAD_2 and CAD_3. Based on these observations, we conclude that OsIDD_2 is negatively involved in SCW formation and other biological events by downregulating its target genes. | Peng Huang Hideki Yoshida Kenji Yano Shunsuke Kinoshita Kyosuke Kawai Eriko Koketsu Masako Hattori Sayaka Takehara Ji Huang Ko Hirano Reynante Lacsamana Ordonio Makoto Matsuoka Miyako Ueguchi-Tanaka | 2018 | Journal of Integrative Plant Biology2018，60，2： | 3 |
| 7 | Relationship specialization amongst sources and receivers of social support and its correlations with loneliness and subjective well-being: A cross sectional study of Nepalese older adults显示文摘 | Hom Nath Chalise Tami Saito Miyako Takahashi Ichiro Kai | 2006 | Archives of Gerontology and Geriatrics2006，，3： | 2 |
| 8 | Usefulness and limitations of taste sensors in the evaluation of palatability and taste-masking in oral dosage forms显示文摘The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations. | Tamami Haraguchi Miyako Yoshida Honami Kojima Takahiro Uchida | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 2 |
| 9 | Investigation on the Perceptions of Living Donors regarding Spousal Renal Donor Transplantation显示文摘 | Miyako Takagi | 2013 | Journal of Life Sciences2013，7，11： | 2 |
| 10 | Hemodynamic and catecholamine responses during tracheal intubation using a lightwand device (Trachlight) in elderly patients with hypertension显示文摘 | Masato Kanaide Makoto Fukusaki Shino Tamura Masafumi Takada Masahiko Miyako Koji Sumikawa | 2003 | Journal of Anesthesia2003，，： | 2 |
| 11 | Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-Methyl-N-Nitro-N- Nitrosoguanidine in wistar rats显示文摘 | Masaharu T Hiroyasu I Miyako B | 1999 | Int J Cancer1999，，： | 1 |
| 12 | Relationship specialization amongst sources and receivers of social support and its correlations with loneliness and subjective well-being: A cross sectional study of Nepalese older adults显示文摘 | Hom Nath Chalise Tami Saito Miyako Takahashi Ichiro Kai | 2006 | Archives of Gerontology and Geriatrics2006，，3： | 1 |
| 13 | Differential diagnosis of ovarian cancer,benign ovarian tumor and endometriosis by a combina- tion assay of serum sialyl SSEA-1 antigen and CA125 levels显示文摘 | Iwanari O Miyako J Date Y | 1990 | Gynecol Obstet Invest1990，29，1： | 1 |
| 14 | Relationship Specialization amongst Sources and Receivers of Social Support and Its Correlations with Loneliness and Subjective Well-Being: A Cross Sectional Study of Nepalese Older 显示文摘 | Horn NC Tami S Miyako T Ichiro K | 2007 | Archives of Gerontology and Geriatrics2007，，44： | 1 |
| 15 | Micropatterned carbon nanotubegel composite as photothermal material 显示文摘 | Miyako E Nagata H Hirano K | 2009 | Adv Mater2009，21，27： | 1 |
| 16 | Whole-body FDG-PET/CT on rheumatoid arthritis of large joints显示文摘 | Kazuo Kubota Kimiteru Ito Miyako Morooka Takuya Mitsumoto Kyoko Kurihara Hiroyuki Yamashita Yuko Takahashi Akio Mimori | 2009 | Annals of Nuclear Medicine2009，，9： | 1 |
| 17 | Demographic, Clinical, and Radiologic Predictors of Neurologic Deterioration in Patients with Acute Ischemic Stroke显示文摘 | Nobukazu Miyamoto Yasutaka Tanaka Yuji Ueno Miyako Kawamura Yoshiaki Shimada Ryota Tanaka Nobutaka Hattori Takao Urabe | 2011 | Journal of Stroke and Cerebrovascular Diseases2011，，： | 1 |
| 18 | Photodynamic thermoresponsive nanocarhon-polymer gel hybrids显示文摘 | Miyako E Nagata H Hirano K | 2008 | Small2008，4，10： | 1 |
| 19 | Light-triggered thermoelectric conversion based on a Carbon nanotubepolymer hybrid gel显示文摘 | Miyako E Nagata H Funahashi R | 2009 | Chem Sus Chem2009，2，5： | 1 |
| 20 | Slender rice, a constitutive gibberellin response mutant, is caused by a null mutation of theSLR1 gene, an ortholog of the height-regulating gene GAI/RGA/RHT/D8 显示文摘 | Akira I Miyako U T Yutaka S etal | 2001 | Plant Cell2001，13，： | 1 |
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