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		题名	作者	年代	出处	被引量
	1	Clinical significance of mucosal suppressors of cytokine signaling 3 expression in ulcerative colitis显示文摘AIM:To investigate the clinical significance of mucosal expression of suppressors of cytokine signaling 1 (SOCS1) and SOCS3 in human ulcerative colitis (UC). METHODS:Biopsy specimens for histological analysis and mRNA detection were obtained endoscopically from the rectum of 62 patients with UC (36 men; age 13-76 years). The patients were classified endoscopically according to Matts' grade (grade 1 to 4). Expression of SOCS1 and SOCS3 mRNAs was quantified in samples by competitive reverse transcription-polymerase chain reaction (RT-PCR). GAPDH was used as an internal control for efficiency of RT-PCR and amount of RNA. RESULTS:SOCS3 mRNA expression was significantly higher in inflamed mucosa of UC than in inactive mucosa. The level of expression was well correlated with the degree of both endoscopic and histologic inflammation. Interestingly,among the patients in remission,the group with relatively low expression of SOCS3 showed a higher rate of remission maintenance over a 12-mo period. In contrast,SOCS1 mRNA was expressed in both inflamed and non-inflamed colonic mucosa and was not correlated with the activity of colonic mucosa or prognosis. CONCLUSION:These observations suggest that increased expression of mucosal SOCS3,but not of SOCS1,may play a critical role in the development of the colonic inflammation of UC.	Yoshihiro Miyanaka Yoshitaka Ueno Shinji Tanaka Kyoko Yoshioka Tsuyoshi Hatakeyama Masaru Shimamoto Masaharu Sumii Kazuaki Chayama	2007	World Journal of Gastroenterology2007，13，21：	2
	2	Induction of endothelial nitric-oxyde syjthase in rat brain astrocytes by systemic lipopolysaccha- ride treatment 显示文摘	Iwase K Miyanaka K Shimizu A	2000	J Biol Chem2000，275，11：	1
	3	Induction of endothelial nitric oxide synthase in rat brain astrocytes by systemic lipopolysaccharide tretament 显示文摘	Iwase K Miyanaka K Shimizu A Nagasaki A Gotoh T Mori M	2000	J Biol Chem2000，275，11：	1
	4	D-allose, an all-cis aldo-hexose, suppresses development of salt-induced hypertension in Dahl rats显示文摘	Shoji Kimura Guo-Xing Zhang Akira Nishiyama Yukiko Nagai Toshitaka Nakagawa Hiroshi Miyanaka Yoshihide Fujisawa Akira Miyatake Tsubasa Nagai Masaaki Tokuda Youichi Abe	2005	Journal of Hypertension2005，，10：	1
	5	Infliximab Therapy for Crohn’s Disease in a Patient with Chronic Hepatitis B显示文摘	Yoshitaka Ueno MD Shinji Tanaka MD Masaru Shimamoto MD Yoshihiro Miyanaka MD Toru Hiyama MD Masanori Ito MD Yasuhiko Kitadai MD Masaharu Yoshihara MD Masaharu Sumii MD Kazuaki Chayama MD	2005	Digestive Diseases and Sciences2005，，1：	1
	6	Regulation of genes for inducible nitric oxide synthase and urea cycle enzymes in rat liver in endotoxin shock显示文摘	Tabuchi S Gotoh T Miyanaka K	2000	Biochem Biophys Res Commun2000，268，1：	1
	7	Infliximab Therapy for Crohn’s Disease in a Patient with Chronic Hepatitis B显示文摘	Yoshitaka Ueno MD Shinji Tanaka MD Masaru Shimamoto MD Yoshihiro Miyanaka MD Toru Hiyama MD Masanori Ito MD Yasuhiko Kitadai MD Masaharu Yoshihara MD Masaharu Sumii MD Kazuaki Chayama MD	2005	Digestive Diseases and Sciences2005，，1：	1
	8	Opti-mization of the inter-domain structure ofgalectin-9 for recombinant production 显示文摘	Itoh A Fukata Y Miyanaka H	2013	Glycobiology2013，23，8：	1

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