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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Development of microwave assisted extraction for the simultaneous determination of isoflavonoids and sa- ponins in radix astragali by high performance liquid chromatography显示文摘 | SONG J Z MO S F YIP Y K ct al | 2007 | J Sep Sci2007，30，6： | 1 |
| 3 | Deep fuels desulfurization and denitrogenation using 1-butyl-3-methylimidazolium trifluoromethanesulfonate显示文摘 | Kedra-Krolik K Mutelet F Moǐse J-C | | 0，，04： | 1 |
| 4 | Multi{unctional magnetic nanoparticles {or targeted delivery显示文摘 | Kumar A Jena P K Behera S Lockey R F Mohapatra S Mo hapatra S | | Nanomedicine0，6，： | 1 |
| 5 | A study of circulat- ing interleukin 10 in prognostication of unresectable hepa- tocellular carcinoma显示文摘 | Chan S L Mo F K Wong C S | 2012 | Cancer2012，118，16： | 1 |
| 6 | Pretreatment of papermaking-reconstituted tobacco slice wastewater by coagulation-flocculation 显示文摘 | Wang Y F Chen K F Mo L H | 2013 | Applied polymer science2013，22，6： | 1 |
| 7 | Optimization of coagulation-flocculation process for papermakingreconstituted tobacco slice wastewater treatment using response surface methodology显示文摘 | Wang Y F Chen K Mo L H | 2014 | Journal of Industrial and Engineering Chemistry2014，20，2： | 1 |
| 8 | Sipl| and Rbekl are novel Eyal-binding proteins with a role in craniofacial development 显示文摘 | Landgraf K Bo|llg F Trowe MO | 2010 | Mol Cell Biol2010，30，24： | 1 |
| 9 | Investigation of microemulsion system for transdermal delivery of meloxicam显示文摘 | YUAN Y LIS M MO F K | 2006 | Int J Pharm2006，321，12： | 1 |
| 10 | The role of apolipoprotein E in Alzheimer's disease, acutebrain injury arid cerebrovascular disease: evidence of common mechanisms arid utility of animal models 显示文摘 | Horsburgh K McCarrom Mo White F | 2000 | Neurobiology of Aging2000，21，： | 1 |
| 11 | Squamous cell carcinoma of the head and neck:diffusion-weighted MR imaging for prediction and monitoring of treatment response显示文摘 | KING A D MO F K YU KH | 2010 | Eur Radiol2010，20，9： | 1 |
| 12 | Investigation of microemul- sign system for transdermal delivery of meloxicam显示文摘 | Yuan Y Li S M Mo F K | 2006 | In- ternational Journal of Pharmaceutics2006，321，12： | 1 |
| 13 | Investigation of mieroemulsion system for transdermal delivery of meloxicam 显示文摘 | YUAN Y LI S M MO F K | 2006 | lnt J Pharm2006，321，12： | 1 |
| 14 | Nitrogen addition shapes soil phosphorus availability in two reforested tropical forests in Southern China显示文摘 | LU X K MO J M GILLIAM F S | 2012 | Biotropica2012，44，3： | 1 |
| 15 | Investigation of microemulsion system for transdermal delivery of meloxicam 显示文摘 | YUAN Y LI S M MO F K | 2006 | Int J Pharm2006，321，12： | 1 |
| 16 | New utility of an oldmarker:serial alpha-fetoprotein measurement in predicting radiologicresponse and survival of patients with hepatocellular carcinomaundergoing systemic chemotherapy 显示文摘 | CHAN S L MO F K JOHNSON P J | 2009 | J Clin Oncol2009，27，3： | 1 |
| 17 | Hepatitis B viral load predicts survival of HCC patients undergoing systemic chemotherapy显示文摘 | Yeo W Mo F K Chan S L | | 0，，06： | 1 |
| 18 | Hepatitis B viral load predicts survival of HCC patients undergoing systemic chemotherapy显示文摘 | Yeo W Mo F K Chan S L | 2007 | Hepatology2007，45，6： | 1 |
| 19 | Development of microwave assisted extraction for the simultaneous determination of isofla- vonoids and saponins in radix astragali by high performance liquid chromatography显示文摘 | Song J Z Mo S F Yip Y K | 2007 | J Sep Sci2007，30，6： | 1 |
| 20 | A study of circulating inerleu- kin-10 in prognosticatication of unresectable hepatocellular carcino- ma显示文摘 | Chan S L Mo F K Wong C S | 2012 | Cancer2012，118，16： | 1 |
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