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| 1 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 2 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 3 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 4 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 5 | Effects of levosimendan on systemic and regional hemodynamics in septic myocar-dial depression 显示文摘 | Mo relli A De Castro S Teboul JL | 2005 | Intens Care Med2005，31，5： | 1 |
| 6 | Pilon fractures:treatment protocol based on severity of soft tissue injury显示文摘 | Moed BR Karges DE | 2000 | Clin Orthop2000，37，5： | 1 |
| 7 | Pilon fracture treatment protocol base on severity of soft tissue injury显示文摘 | Wartson JT Moed BR Karges DE | 2000 | Clin Orthop2000，375，： | 1 |
| 8 | The role of coping strategies in quality of life of adolescents with asthma显示文摘 | Van De Ven MO Engels RC Sawyer SM Otten R Van Den Eijnden RJ | 2007 | Qual Life Res2007，，2： | 1 |
| 9 | Pilon fracture:Treatment protocol based on severity of soft tissue injury显示文摘 | Watson JT Moed DE | 2000 | Clin Orthop2000，，： | 1 |
| 10 | Pilon fractures treatment protocol based on severity of soft tis sue injury显示文摘 | Watson JT Moed BR Karges DE | 2000 | Clin Orthop Relat Res2000，，375： | 1 |
| 11 | Cerebrosp inal fluid lekage during transsphenoidal surgery:postoperetive external lumbardrainage reduces the risk formenigitis显示文摘 | Van Aken MO Feelden RA De Marie S | 2004 | Pituitary2004，7，2： | 1 |
| 12 | Pilon fractures:treatment protocol based on severity of soft tissue iniury显示文摘 | Watson JT Moed BR Karges DE | 2000 | Clin Orthop2000，，375： | 1 |
| 13 | Sublingual immunotherapy not effective in house dust mite-allergic children in primary care 显示文摘 | de Bot CM Moed H Berger MY | 2012 | Pediatr Allergy Immunol2012，23，2： | 1 |
| 14 | Pilon fractures:treatment protocol based on severity of soft tissue injury显示文摘 | Watson JT Moed BR Karges DE | | 0，，375： | 1 |
| 15 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 16 | Pilon fracture:the treatment protocol based on severity of soft tissue injury显示文摘 | Watson JT Moed BR Karges DE | 2000 | Clin Orthop2000，375，6： | 1 |
| 17 | Pi- lon fractures: treatment protocol based on severity of sof tissue injury显示文摘 | Watson JT Moed BR Karges DE | 2000 | Clin Orthop2000，，375： | 1 |
| 18 | Incidence and risk factors for agranulocytosis in Latin American countries—the Latin Study显示文摘 | Nelson Hamerschlak Eliane Maluf Alexandre Biasi Cavalcanti álvaro Avezum Júnior José Eluf-Neto Roberto Passeto Falc?o Irene Gyongyvér Heidemarie Lorand-Metze Daniel Goldenberg Cézar Leite Santana Daniela de Oliveira Werneck Rodrigues Leny Nascimento da Mo | 2008 | European Journal of Clinical Pharmacology2008，，9： | 1 |
| 19 | Pilon fractures:treatment protocolbased on severity of soft tissue injury显示文摘 | Watson JT Moed BR Karges DE | 2000 | Clin Orthop2000，，375： | 1 |
| 20 | Pilon fracture: treatment protocol based on severity of soft tissue injury显示文摘 | Tracy Watson J Moed BR Karges DE | 2000 | Clin Orthop2000，375，： | 1 |
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