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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Retinal nerve fiber layer measurement of the Hong Kong Chinese population by optical coherence tomography显示文摘 | Mok K H Lee V W So K F | 2002 | J Glau2002，11，6： | 1 |
| 3 | Effects of thidiazuron on cytokinin autonomy and the metabolism of N6-C2 isopenteny adenosine in callus tissues of Phaseolus lunatus显示文摘 | Capelle S C Mok D W S Kirchner S C | 1983 | Plant Physiol1983，73，： | 1 |
| 4 | Cytokinin acitivity of Nphenyl-1,2,3-thidiazol-5-ylurea (TDZ)显示文摘 | Mok M C Mok D W S Armstrong D J | 1982 | Phytochemistry1982，21，： | 1 |
| 5 | Cancer of the stomach:a review of two hospitals in Korea and Japan显示文摘 | Mok Y J Koo B W Whang C W | 1993 | World J Surg1993，17，6： | 1 |
| 6 | Differential radiosensitizing effect of valproic acid in differentiation versus serf-renewal promoting culture conditions显示文摘 | Debeb BG Xu W Mok H | 2010 | IntJ Radiat Oncol Biol Phys2010，76，3： | 1 |
| 7 | Statins for asymptomatic middle cerebral artery stenosis: The Regression of Cerebral Artery Stenosis Study显示文摘 | Mok V C Lam W W Chen X Y | 2009 | Cerebrovasc Dis2009，28，1： | 1 |
| 8 | Long term survival of southern Chinese patients with systemic lupus erythematosus:a prospective study of all age groups显示文摘 | MOK C C MAK A CHU W P | 2005 | Medicine(Baltimore)2005，84，4： | 1 |
| 9 | Flue gas treatment using pulsed corona discharge generated by magnetic pulse compression modulator 显示文摘 | MOK Y S LEE H W HYUN Y J | 2001 | Journal of Electrostatics2001，53，3： | 1 |
| 10 | Cytokinin activity of N-phenyl-N-1,2,3-thidiazol-5-ylurea (TDZ)显示文摘 | Mok M C Mok D W S Armstrong D J | 1982 | Phytochemistry1982，，21： | 1 |
| 11 | Conversion of NO to NO2 in air by a pulsed corona discharge process显示文摘 | Ham S W | 1998 | Chemical Engineering Science1998，53，9： | 1 |
| 12 | Potency of bupivacaine stereoisomers tested in vitro and in vivo:biochemical,electrophysiological and neurobehavioral studied显示文摘 | Vladimirov M Nau C Mok W M | 2000 | Anesthesiology2000，93，： | 1 |
| 13 | New criterion for internal crack fomlation in continuously cast steels显示文摘 | Mok W Y Jung Y T Jin S D | 2000 | Metallurgical and Materials Transactions B2000，31，8： | 1 |
| 14 | Total flavonoid fraction of the Herba epimedii extract suppresses urinary calci- um excretion and improves bone properties in ovariectomised mice显示文摘 | CHEN W F MOK S K WANG X L | 2011 | BrJ Nutr2011，105，2： | 1 |
| 15 | Prospectively versus retro- spectively ECG-gated 256-slice CT angiography to assess coro- nary artery bypass gralts comparison of image quality and radia- tion dose显示文摘 | Lee Y W Yang C C Mok G S | 2012 | PLoS one2012，7，49： | 1 |
| 16 | Productive and parasitic pathways in dilute acid-catalyzed hydrolysis of cellulose 显示文摘 | Mok W S L Antal M J | 1992 | Industrial and Engeneering Chemistry Research1992，31，2： | 1 |
| 17 | Matrix metalloproteinases-I and -8 improve the distribution and efficacy of an oncolytic virus 显示文摘 | Mok W Boueher Y Jain RK | 2007 | Cancer Res2007，67，10： | 1 |
| 18 | Use-dependent inhibition of Na ^+ currents by Benzocaine homologs显示文摘 | Quan C Mok W M Wang G K | 1996 | Biophys J1996，70，1： | 1 |
| 19 | Cytokinin activity of N-phenyl-N'-1, 2, 3-thiasiazol-5-ylurea (thidiazuron) 显示文摘 | Mok M C Mod D W S | 1982 | Phytochemistry1982，21，： | 1 |
| 20 | A data mining framework for building intrusion detection models显示文摘 | Lee W Stolfo S J Mok K W | 1999 | in In IEEE Symposium on Security and Privacy1999，，： | 1 |
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