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| 1 | An eighteen-month follow-up study on the effects of Intravitreal Dexamethasone Implant in diabetic macular edema refractory to anti-VEGF therapy显示文摘AIM: To evaluate the long-term efficacy and safety of dexamethasone implants in subjects affected by diabetic macular edema(DME) resistant to anti-vascular endothelial growth factor(VEGF) therapy.METHODS: Thirty-two DME patients were enrolled.A700 microgram slow release Intravitreal Dexamethasone Implant(Ozurdex~) was placed in the vitreous cavity.All patients were followed for 18 mo.Best-corrected visual acuity(BCVA) measured with Early Treatment Diabetic Retinopathy Study(ETDRS) and central macular thickness(CMT) exams were carried out at baseline(T0)and after 1(T1),3(T3),4(T4),6(T6),9(T9),12(T12),15(T15),and 18mo(T18) post injection. RESULTS: Repeated measures ANOVA showed an effect of treatment on ETDRS(P<0.0001).Post hoc analyses revealed that ETDRS values were significantly increased at T1,T3,T4,T9,and T15(P <0.001) as compared to baseline value(T0).At T6,T12,and T18,ETDRS values were still statistically higher than baseline(P<0.001 vs T0).However,at these time points,we observed a trend to return to baseline conditions.ANOVA also showed an effect of treatment(P <0.0001).CMT decreased significantly at T1,T3,T4,T9,and T15(P<0.001).At T6(P<0.01),T12 and T18(P<0.001) CMT was also significantly lower than T0 although a trend to return to the baseline conditions was also observed.CONCLUSION: Our findings demonstrate that Intravitreal Dexamethasone Implant is a good option to improveBCVA and CMT in DME patients resistant to anti-VEGF therapy.Our data also show that the use of drugs administered directly into the vitreous allows achieving appropriate and long-lasting concentration at the site of disease without systemic side effects. | Fernanda Pacella Maria Rosaria Romano Paolo Turchetti Giovanna Tarquini Anna Carnovale Antonella Mollicone Alessandra Mastromatteo Elena Pacella | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 5 |
| 2 | The animalsialyltransferases and sialyltransferase-related genes:aphyloge-netic approach显示文摘 | Harduin-Lepers H Mollicone R Delannoy P | 2005 | Glycobiology2005，15，： | 1 |
| 3 | The nucleotide-sugar transporter family: a phylogenetic approach显示文摘 | Martinez-Duncker I Mollicone R Codogno P | 2003 | Biochimie2003，85，34： | 1 |
| 4 | Alternative simulation techniques for distortion of thin plate due to fillet-welded stiffeners 显示文摘 | CAMILLERI D MOLLICONE P GRAY T F | 2006 | Modelling and Simulation in Materials Science and Engineering2006，14，8： | 1 |
| 5 | The animal sialyltransferases and sialyltransferase-related genes:a phylogenetic approach显示文摘 | Harduin-Lepers A Mollicone R Delannoy P | 2005 | Glycobiology2005，15，： | 1 |
| 6 | Molecular genetics of H 显示文摘 | Oriol R Candelier JJ Mollicone R | 2000 | Vox Sang2000，78，2： | 1 |
| 7 | Simple ther-mo-elastic-plastic models for welding distortion simulation显示文摘 | Mollicone P Camilleri D Gray T G F | 2006 | Journal of Materials Processing Technology2006，176，123： | 1 |
| 8 | Characterization and functionalization by sol-gel route of SiC foams 显示文摘 | Mollicone J Ansart F Lenormand P | 2014 | Jour nal of the European Ceramic Society2014，34，15： | 1 |
| 9 | Simple thermo-elastieplastic models for welding distortion simulation 显示文摘 | Mollicone P Camilleri D Gray T G F | 2006 | Jouronl of Materials Processing Technology2006，176，3： | 1 |
| 10 | Molecular genetics of H,Se,Lewis and other fucosyltransferase genes显示文摘 | Mollicone R Cailleau A Oriol R | | 0，，04： | 1 |
| 11 | Validity and sensitivity of a brief psychomotor vigilance test (PVT-B) to total and partial sleep deprivation显示文摘 | Basner M Mollicone D Dinges DF | | 0，，： | 1 |
| 12 | Procedural influences on non-linear distortions in welded thin-plate fabrication 显示文摘 | Mollicone P | 2008 | Thin- Walled Structures2008，46，79： | 1 |
| 13 | Simple thermo--elastic-plastic models for welding distor- tion simulation显示文摘 | MOLLICONE P CAMII I ERI D GRAY T G F | 2006 | Journal of Materials Processing Techno- logy2006，176，1： | 1 |
| 14 | Validity and sensitivity of a briefpsychomotor vigilance test (PVT-B) to total and partial sleepdeprivation显示文摘 | Basner M Mollicone D Dinges DF | 2011 | Acta Astronautica2011，69，11： | 1 |
| 15 | The animal sialtransferase and sialyltransferase -related genes: a phylogenetic approach 显示文摘 | Harduin-Lepers A Mollicone R Delannoy P | 2005 | Glycobiology2005，15，8： | 1 |
| 16 | Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duratienand timing显示文摘 | Basner M Dinges D.F Mollicone D | | 0，，： | 1 |
| 17 | The animal sia- lyhransferases and sialyltransferase-related genes : a phylogenetic ap- proach 显示文摘 | Harduin-Lepers A Mollicone R Delannoy P | 2005 | Glycobiology2005，15，8： | 1 |
| 18 | Computational methods and experimental validation of welding distortion models 显示文摘 | Camilleri D Mollicone P Gray T G F | 2007 | Proceedings of the Institution of Mechanical Engineers Part L: Journal of Materials Design and Applications2007，221，4： | 1 |
| 19 | Ecology: human role in Rus- sian wild fires显示文摘 | Mollicone D Eva H D Achard F | 2006 | Nature2006，440，： | 1 |
| 20 | Genetics of ABO, H, Lewis,X and related antigens显示文摘 | Oriol R Le Pendu J Mollicone R | 1986 | Vox Sang1986，51，3： | 1 |
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