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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 3 | The Changes in health-related quality of life and related factors during the process of total hip arthroplasty显示文摘 | Montin L Suominen T Haaranen E | 2011 | Int J Nurs Pract2011，17，1： | 1 |
| 4 | Total joint arthro- plasty patients perception of received knowledge of care 显示文摘 | Montin L Johansson K Kettunen J | 2010 | Orthop Nurs2010，29，4： | 1 |
| 5 | Extended results of the Alzheimer's disease anti-inflammatory prevention trim 显示文摘 | Breitner JC Baker LC Montine TJ | 2011 | Alzheim- ers Dement2011，7，： | 1 |
| 6 | Malignant transformation a eulcaryotic initiation factor subunit that binds to mRNA 5'cap显示文摘 | Lazaris Karatzas A Montine K S Sonenberg N | | 0，，： | 1 |
| 7 | Prostanoid signaling:Dual role for prostaglandin E2 in neurotoxicity显示文摘 | Milatovic D Montine T J Aschner M | 2011 | Neuro Toxicol2011，32，3： | 1 |
| 8 | The changes in health-relat- ed quality of life and related factors during the process of total hip arthroplasty 显示文摘 | Montin L Suominen T Haaranen E | 2011 | Int J Nurs Pract2011，17，1： | 1 |
| 9 | A randomized placebo - con- trolled pilot trial of omega - 3 fatty acids and alpha lipoic acid in Alzheimer's disease 显示文摘 | Shinto L Quinn J Montine T | 2014 | J Alzheimers Dis2014，38，1： | 1 |
| 10 | Recommendations of the Alzheimer's disease-related dementias conference 显示文摘 | Montine TJ Koroshetz WJ Babcock D | 2014 | Neurology2014，83，9： | 1 |
| 11 | Anxiety and health related quality of life of patients undergoing total hip arthroplasty for osteoarthritis 显示文摘 | Montin L Leino-Kilpi H Katajisto J | 2007 | Chronic Illness2007，3，3： | 1 |
| 12 | Management of the urethra in men undergoing radial cystectomy for bladder cancer显示文摘 | Zabbo A Montine JE | 1984 | J Urol1984，131，2： | 1 |
| 13 | Surgical Neuropathology Update: A Review of Changes Introduced by the WHO Classification of Tumours of the Central Nervous System, 4th Edition显示文摘 | Brat Daniel J Parisi Joseph E Kleinschmidt-DeMasters Bette K Yachnis Anthony T Montine Thomas J Boyer Philip J Powell Suzanne Z Prayson Richard A McLendon Roger E | 2008 | Archives of Pathology & Laboratory Medicine2008，，6： | 1 |
| 14 | False Positive Tardus-Parvus Waveforms After Liver Transplantation: A Case of Wide Discrepancy Between Donor and Recipient Hepatic Arteries Mimicking Anastomotic Stenosis显示文摘 | L. Urbani L. Morelli A. Campatelli U. Montin G. Catalano G. Biancofiore L. Bindi I. Bargellini R. Cioni C. Vignali G. Di Candio F. Mosca F. Filipponi | 2008 | Transplantation Proceedings2008，，10： | 1 |
| 15 | Proteomic biomarker discovery in cerebrospinal fluid for neurodegenerative diseases显示文摘 | Zhang J Goodlett D R Montine T J | | 0，，04： | 1 |
| 16 | Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)显示文摘 | Thomas Montine Joshua Sonnen | 2009 | Journal of Alzheimer’s Disease2009，，3： | 1 |
| 17 | Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults 显示文摘 | Fishel MA Watson GS Montine TJ | 2005 | Arch Neurol2005，62，10： | 1 |
| 18 | Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease显示文摘 | Quinn JF Montine KS Moore M | 2004 | J Alzheimers Dis2004，6，1： | 1 |
| 19 | National Institute on Aging-Alzheimers Association guidelines for the neuropathologic assessment of Alzheimers disease:a practical approach显示文摘 | Montine TJ Phelps CH Beach TG | 2012 | Acta Neuropathol2012，123，1： | 1 |
| 20 | Extended results of the Alzheimer's disease anti-inflammatory prevention trial 显示文摘 | Breitner J C Baker L D Montine T J | 2011 | Alzheimers Dement2011，7，4： | 1 |
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