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| 1 | Early surgery in Crohn's disease a benefit in selected cases显示文摘AIM: To compare the outcomes of a cohort of Crohn's disease(CD) patients undergoing early surgery(ES) to those undergoing initial medical therapy(IMT).METHODS: We performed a review of a prospective database CD patients managed at a single tertiary institution. Inclusion criteria were all patients with ileal or ileocolonic CD between 1995-2014. Patients with incomplete data, isolated colonic or perianal CD were excluded. Primary endpoints included the need for, and time to subsequent surgery. Secondary endpoints included the number and duration of hospital admissions, and medical therapy. RESULTS: Forty-two patients underwent ES and 115 underwent IMT. The operative intervention rate at 5 years in the ES group was 14.2% vs IMT 31.3%(HR = 0.41, 95%CI: 0.23-0.72, P = 0.041). The ES group had fewer hospital admissions per patient [median 1 vs 3(P = 0.012)] and fewer patients required anti-TNF therapy than IMT(33.3% vs 57%, P = 0.003). A subgroup analysis of 62 IMT patients who had undergone surgery were compared to ES patients, and showed similar 5 year(from index surgery) re-operation rates 16.1% vs 14.3%. In this subset, a significant difference was still found in median number of hospital admissions favouring ES, 1 vs 2(P = 0.002).CONCLUSION: Our data supports other recent studies suggesting that patients with ileocolonic CD may have a more benign disease course if undergoing early surgical intervention, with fewer admissions to hospital and atrend to reduced overall operation rates. | Vinna An Lauren Cohen Matthew Lawrence Michelle Thomas Jane Andrews James Moore | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 2 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes显示文摘 | Xiaokang Wu Chaofeng Ma Lei Han Muhammad Nawaz Fei Gao Xuyan Zhang Pengbo Yu Chang’an Zhao Lianchuan Li Aiping Zhou Juan Wang John E. Moore B. Cherie Millar Jiru Xu | 2010 | Current Microbiology2010，，1： | 2 |
| 3 | Protein kinase-mediated regulation of the Na^+/H^+ exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways显示文摘 | Moor AN Fliegel L | 1999 | J Biol Chem1999，274，22： | 1 |
| 4 | The role of extracellular signal-regulated kinase in cognitive and motor deficits following experimental traumatic brain injury显示文摘 | Dash PK Mach SA Moore AN | 2002 | Neuroscience2002，114，3： | 1 |
| 5 | one machine sequencing algorithm for minimizing the number of late jobs显示文摘 | Moore J M An n job | 1968 | Management Science1968，15，3： | 1 |
| 6 | Persistent working memory dysfuction following traumatic brain injury: evi?dence for a time-dependent mechanism显示文摘 | Hoskison M M Moore AN Hu B | 2009 | Neuroscience2009，159，2： | 1 |
| 7 | Enhanced neurogenesis in therodent hippocampus following traumatic brain injury 显示文摘 | Dash PK Mach SA Moore AN | 2001 | JNeurosci Res2001，63，4： | 1 |
| 8 | Identification of serum biomarkers in brain - injured adults: potential for predicting elevated intracranial pressure 显示文摘 | Hergenroeder G Redell JB Moore AN | 2008 | J Neurotrauma2008，25，2： | 1 |
| 9 | Regional expression and role ofcy- clooxygenase -2following experimental traumatica brain inju -ry 显示文摘 | Dash PK Mach SA Moore AN | 2000 | Neurotramna2000，17，1： | 1 |
| 10 | Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury显示文摘 | Dash PK Mach SA Moore AN | 2001 | J Neurosci Res2001，63，4： | 1 |
| 11 | A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory 显示文摘 | Blum S Moore AN Adams F etal | 1999 | J Neurosci1999，19，9： | 1 |
| 12 | The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass显示文摘 | Moore RG Brown AN Miller Me | 2008 | Gynecol Oncol2008，108，2： | 1 |
| 13 | Biomarkers in the clinical diagnosis and management of traumatic brain injury 显示文摘 | Hergenroeder GW Redell JB Moore AN | 2008 | Mol Diagn Ther2008，12，： | 1 |
| 14 | Biomarkers in the clinical diagnosis and management of traumatic brain injury显示文摘 | Hergenroeder GW Redell JB Moore AN | 2012 | Mol Diagn Ther2012，12，6： | 1 |
| 15 | A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory显示文摘 | Blum S Moore AN Adams F | 1999 | J Neurosci1999，19，9： | 1 |
| 16 | PA mitogenactivated protein kinase cascade in the CA1/CA2subfield of the dorsal hippocampus is essential for longterm spatial memory显示文摘 | Blum S Moore AN Adams F | 1999 | J Neurosci1999，19，9： | 1 |
| 17 | Breast cancer metastasizing to the pelvis and abdomen: what the gynaecologist needs to know显示文摘 | Moore EK Roylance R Rosenthal AN | 2012 | BJOG2012，119，7： | 1 |
| 18 | Sulforaphane enhances aquaperin-4 expression and decreases cerebral edema following traumatic brain injury显示文摘 | Zhao J Moore AN Clifton GL | 2005 | J Neurosci Res2005，82，4： | 1 |
| 19 | Biomarkers in the clinical diagnosis and management of traumatic brain injury显示文摘 | Hergenroeder GW Redell JB Moore AN | 2008 | Mol Diagn Ther2008，12，6： | 1 |
| 20 | Enchanced neurogenesis in the rodent hippocampus following traumatic brain injury显示文摘 | Dash PK Mach SA Moore AN | 2001 | J Neurosci Res2001，63，4： | 1 |
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