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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | Spatial and temporal dynamics of vegetation in the San Pedro River Basin area显示文摘 | Qi J R C Marsett M S Moran | 2000 | Agricultural and Forest Meteorology2000，105，13： | 2 |
| 4 | Pathophysiology of protracted acute renal failure in man显示文摘 | MORAN S M MYERS B D | 1985 | J Clin Invest1985，76，4： | 1 |
| 5 | Microcontact printing of catalytic nanoparticles for selective electroless deposition of metals on nonplanar polymeric substrates 显示文摘 | Ng W K Wu L Moran P M | 2002 | Appl Phys Lett2002，81，16： | 1 |
| 6 | Synthesis and biological evaluation of methoxyphenyl p0orphyrin derivatives as potential photodynamic agent 显示文摘 | MILANESIO M E MORAN F S YSLAS I E | 2001 | Bioorg Med Chem2001，9，8： | 1 |
| 7 | A study of the effect of a single neurotoxic dose of 3, 4-Methylenedloxymethamphetamine ( MDMA; 'Ecstasy') on the subsequent longterm behavior of rats in the plus maze and open field 显示文摘 | Mechan A Moran PI Elliott M | 2002 | Psychopharmacol2002，159，2： | 1 |
| 8 | FIE and CURLY LEAF polycomb proteins inte ract in the regulation of homeobox gene expression during sporophyte development显示文摘 | AVIVA K MORAN O ASSAF M | 2004 | The Plant Journal2004，37，5： | 1 |
| 9 | Interaction of photochemical and microbial processes in the degradation of refractory dissolved organic matter from a coastal marine environment显示文摘 | Miller W J Moran M A | 1997 | Limonl Oceanogr1997，42，： | 1 |
| 10 | Combining remote sensing and modeling for estimating surface evaporation and biomass production 显示文摘 | Moran M S Maas S J Pinter PJ | 1995 | Remote Sensing Review1995，12，： | 1 |
| 11 | Integrins as therapeutic tar gets:lessons and opportunities显示文摘 | Cox D Brennan M Moran N | 2010 | Nat Rev Drug Discov2010，9，10： | 1 |
| 12 | Robust hierarchical multiple hypothesis tracker for multiple-object tracking 显示文摘 | ZULKIFLEY M A MORAN B | 2012 | Expert Systems with Applications2012，39，12： | 1 |
| 13 | Early mortality after hip fracture is delay before surgery important? 显示文摘 | MORAN C G WENN R T SIKAND M | 2005 | J B one Joint Surg (A m)2005，87，3： | 1 |
| 14 | Optical lightpipe as a high -band width fusion diagnostic显示文摘 | Moran M J Lerche R A G Mant | 2006 | Rev Sci Inslrum2006，77，10： | 1 |
| 15 | Acoustic array trackingperformance under moderately complex environmental conditions显示文摘 | Moran M L Greenfield R J Wilson D K | 2007 | Applied Acoustics2007，68，10： | 1 |
| 16 | Genome instabil- ity is increased in lymphocytes of women with polycystic ovary syndrome and is correlated with insulin resistance 显示文摘 | MORAN LJ NOAKES M CLIFTON PM | 2008 | Mutat Res2008，639，12： | 1 |
| 17 | Pemetrexed:biochemical and cellular pharmacology,mechanisms,and clinical applications显示文摘 | Chattopadhyay S Moran RG Goldman M | 2007 | Mol Cancer Ther2007，6，2： | 1 |
| 18 | Isolation and expression pattern of a cDNA encoding a cathepsin B-like protease from Nicotiana rustica显示文摘 | Lidgett A J Moran M Wong K A L | 1995 | Plant Molecular Biology1995，29，2： | 1 |
| 19 | Biophysical parameter estimations using multidirectional spectral measurements显示文摘 | QI Jia-guo CABOT F MORAN M | 1995 | Remote Sensing of Environment1995，54，1： | 1 |
| 20 | Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome:a systematic review and meta-analysis 显示文摘 | Moran L J Misso M L Wild R A | 2011 | Hum Reprod Update2011，16，4： | 1 |
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