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| 1 | Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish显示文摘到许多蛋白质的小 ubiquitin 相关的修饰词(相扑) 变化形式调整多样的细胞的过程,包括抄写,房间周期规定和染色体正直的维护。在 vivo 调查相扑 paralogs 的生物功能,我们在 zebrafish 的早开发使他们失去活性。当作为 Ubc9 缺乏的,为所有三相扑 paralogs 缺乏的 zebrafish 胚胎显示了严重缺点时,单个相扑 paralog 的损失与正常开发兼容。相扑缺乏的胚胎能被一个单个人或 zebrafish 相扑救。当关键时结构的基本离氨酸残余和 N 终端相扑的未组织的段是批评的为在 vivo 营救, SUMO2 的一致 K11 sumoylation 地点是非必需的,在这个潜在的地点上暗示那链形成为正常开发是非本质的。所有三相扑的 Inactivation 触发了 p53 依赖的 apoptosis, p53 的进一步的 inactivation 恢复了正常 zebrafish 开发。有趣地,我们也证明 p53 的主导的否定截断的形式,螖 1 13p53,显著地弄钝相扑在 vivo 的导致弄空的 p53 活动。一起拿,我们的结果建议相扑 paralogs 不可缺少,却冗余,在 zebrafish 的早发展。 | Hao Yuan Jun Zhou Min Deng Xi Liu Morgane Le Bras Hugues de The Sai Juan Chen Zhu Chen Ting Xi Liu Jun Zhu | 2010 | Cell Research2010，20，2： | 4 |
| 2 | Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse显示文摘Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the brain.While increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly demonstrated,the cell type-specific expression of P2X7 and its expression in extra-hippocampal brain structures remains incompletely explored.In this study,P2X7 expression was visualized by using a transgenic mouse model overexpressing P2X7 fused to the fluorescent protein EGFP.The results showed increased P2X7-EGFP expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus,cortex,striatum,thalamus and cerebellum,and this was most evident in microglia and oligodendrocytes.Colocalization of P2X7-EGFP with cell type-specific markers was not detected in neurons or astrocytes.These data suggest that P2X7 activation is a common pathological hallmark across different brain structures,possibly contributing to brain inflammation and neurodegeneration following acute seizures and during epilepsy. | James Morgan Mariana Alves Giorgia Conte Aida Menendez-Mendez Laura de Diego-Garcia Gioacchino de Leo Edward Beamer Jonathon Smith Annette Nicke Tobias Engel | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 3 | Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy显示文摘 | de Veciana M Major CA Morgan MA | 1995 | N EngL J Med1995，9，19： | 1 |
| 4 | Will MOOCs Transform Learning and Teaching in Higher Education?Engagement and Course Retention in On- line Learning provision 显示文摘 | Sara Isabella de Freitas John Morgan David Gibson | 2015 | British Journal of Educational Technology2015，，46： | 1 |
| 5 | Comparison of levator ani mus- cle defects and function in women with and without pelvic organ prolapse 显示文摘 | DeLancey JO Morgan DM Fenner DE | 2007 | Obstet Gynecol2007，109，21： | 1 |
| 6 | Acute necorotizing pancreaatilis显示文摘 | Baron T Morgan DE | 1999 | N Eng J Med1999，340，18： | 1 |
| 7 | Development and pilottesting of a communication aid to assist clinicians to communicatewith women diagnosed with ductal carcinoma in situ (DCIS) 显示文摘 | De Morgan SE Butow PN Lobb EA | 2011 | Support Care Cancer2011，19，5： | 1 |
| 8 | Effects of age and mild hearing loss on speech recognition in noise显示文摘 | Dubno JR Dirks DD Morgan DE | | J Acoust Soc Am0，76，： | 1 |
| 9 | Acute necrotizing pancteatits显示文摘 | Baton TH Morgan DE | 1999 | N Engl J Med1999，340，： | 1 |
| 10 | Pathological features and inhaled corticosteroid response of eosinophilic and non- eosinophilic asthma显示文摘 | Berry M Morgan A Shaw DE | 2007 | Thorax2007，62，： | 1 |
| 11 | Acute necrotizing pancreatitis显示文摘 | Morgan DE | 1999 | N Engl J Med1999，340，18： | 1 |
| 12 | Effects on SOx and NOx emission by co - firing straw and pulverized coal 显示文摘 | Pedersen L S Morgan D J van de Kamp W L | 1997 | Energy & Fuels1997，，11： | 1 |
| 13 | Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma显示文摘 | Berry M Morgan A Shaw DE | 2007 | Thorax2007，62，12： | 1 |
| 14 | Comparison of levator antimuscle defects and function in women with and without pelvic organ prolapse 显示文摘 | Delancey JO Morgan DM Fenner DE | 2007 | Obstet Gynecol2007，109，： | 1 |
| 15 | Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma显示文摘 | Berry M Morgan A Shaw DE | 2007 | Thorax2007，62，： | 1 |
| 16 | Reversed diastolic flow in the renal transplant:perioperative implications versus transplants older than 1 month显示文摘 | Lockhart ME Wells CG Morgan DE | | 0，，03： | 1 |
| 17 | Comparative analysis of urinary incontinence severity after autologous fascia pubovaginal sling, pubovaginal sling and tension-free vaginal tape 显示文摘 | Morgan DM Dunn RL Fenner DE | 2007 | J Urol2007，177，2： | 1 |
| 18 | Comparison of levator ani muscle defects and function in women with and without pelvic organ prolapse显示文摘 | DeLancey JO Morgan DM Fenner DE | | 0，，2： | 1 |
| 19 | Resectability of pancreatic adenocarcinoma in patients with locally advanced disease downstaged by preoperative therapy : a challenge for MDCT 显示文摘 | Morgan DE Waggoner CN Canon CL Lockhart ME Fine-berg NS Posey JA Vickers SM | 2010 | A JR Am J Roentgenol2010，19，194： | 1 |
| 20 | Stenotrophomonas( Xanthomonas ) maltophilia infection in neerotizing panereatitis显示文摘 | Monkemuller KE Morgan DE Baron TH | 1999 | Int J Panereatol1999，25，1： | 1 |
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