|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 3 | Improvement for Mass-exchange Networkr Design显示文摘 | Castro P Motas H Femandes M C | 1999 | Chemical Engineering Science1999，54，11： | 1 |
| 4 | Towards property oriented testing 显示文摘 | MACHADO P D L SILVA D A MOTA A C | 2007 | Electrical Notes in Theoretical Computer Science2007，184，： | 1 |
| 5 | Correlation between placental bacterial culture results and histological chorioamnionitis:a prospective study on 376 placentas 显示文摘 | Queiros da Mota V Prodhom G Yan P | 2013 | Clin Pathol2013，66，3： | 1 |
| 6 | Gypsicolous flora, conservation and restoration of quarries in the southeast of the Iberian Peninsula显示文摘 | J.F. Mota A.J. Sola M.L. Jiménez-Sánchez F. Pérez-García M.E. Merlo | 2004 | Biodiversity and Conservation2004，，10： | 1 |
| 7 | Impact of gas composition on natural gas storage by adsorption显示文摘 | Mota J P B | 1999 | AIChE Journal1999，45，98： | 1 |
| 8 | Correlation between placental bacterial culture results and histological chorioamnionitis: a prospective study on 376 placentas 显示文摘 | Queiros Da Mota V Prodhom G Yan P | 2013 | J Clin Pathol2013，66，3： | 1 |
| 9 | Test-retest and in- trarater reliability of 2-dimensional ultrasound measure- ments of distance between rectus abdominis in women显示文摘 | Mota P Pascoal AG Sancho F | 2012 | J Orthop Sports Phys Ther2012，42，11： | 1 |
| 10 | Associations between abortion, mental disorders, and suicidal behavior in a nationally representative sample 显示文摘 | Mota N P Burnett M Sareen J | 2010 | Can J Psychiatry2010，55，4： | 1 |
| 11 | Low GWP alternatives to HFC - 245fa in organic rankine cycles for low temperature heat recovery: HCFO - 1233zd - E and HFO - 1336mzz - Z显示文摘 | Mol6s F J Navarro - Esbri B P A Mota - Babiloni O | 2014 | Applied Thermal Engineering2014，71，： | 1 |
| 12 | Pulmonary reha- bilitation in patients with bronchiectasis: pulmonary fun- ction, arterial blood gases, and the 6-minute walk test 显示文摘 | Van Z M Mota P C Amorim A | 2012 | Journal of Cardiopulmonary Rehabilitation & Prevention2012，32，5： | 1 |
| 13 | Dynamics of natural gas adsorption storage systems employing activated carbon显示文摘 | BARBOSA MOTA J P RODRIGUES A E | 1997 | Carbon1997，35，9： | 1 |
| 14 | Preparation of ingredients containing an ACE-inhibitory peptide by tryptic hy- drolysis of whey protein concentrates显示文摘 | FERREIRA I M P L V O PINHO O MOTA M V | 2007 | International Dairy Journal2007，17，5： | 1 |
| 15 | Single-column simulated-moving-bed process with recycle lag显示文摘 | Mota J P B Araujo J M M | 2005 | AIChE Journal2005，51，6： | 1 |
| 16 | Enzymatic di- gestion and uhrasonication: a powerful combination in analytical chemistry显示文摘 | Bermejo P Capelo JL Mota A | 2004 | TrAC Trends in Analytical Chemistry2004，23，9： | 1 |
| 17 | A synopsis of the genus Bur- saphelenchus Fuchs, 1937 ( Aphelenchida : Parasitaphelenchi- dae) with keys to species显示文摘 | Ryss A Vieira P Mota M | 2005 | Nerrtatology2005，7，3： | 1 |
| 18 | A simulation model of a high-capacity methane adsorptive storage system显示文摘 | MOTA J P B RODRIGUES A E TONDEUR D | 1995 | Adsorption1995，1，1： | 1 |
| 19 | Fermentation coupled with microfihration: kinetics of ethanol fermentation with ceil recycle 显示文摘 | Mota M Lafforgue C Strehaiano P | 1987 | Bioprocess Eng1987，2，： | 1 |
| 20 | Early extubation does not increase complication rates after coronary artery bypass graft surgery with cardiopulmonary bypass显示文摘 | REIS J MOTA J PONCE P | 2002 | Eur J Cardiothorac Surg2002，21，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员