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| 1 | Effect of phosphorus fluctuation caused by river water dilution in eutrophic lake on competition between blue-green alga Microcystis aeruginosa and diatom Cyclotella sp.显示文摘Tega-numa (Lake Tega) is one of the eutrophic lakes in Japan. For the improvement of water quality in Lake Tega, the North-chiba Water Conveyance Channel was constructed in 2000, which transfer water from Tone River into the lake. After 2000, the dominant species of diatoms, mainly Cyclotella sp., have been replacing blue-green algae, mainly Microcystis aeruginosa in Lake Tega. This transition of dominant species would be due to the dilution, but the detail mechanism has not been understood yet. This study examined the relationship between phosphorus fluctuation caused by river water dilution to Lake Tega and dominance of algal species, M. aeruginosa or Cyclotella sp. based on the single-species and the mixed-species culture experiments. The single-species culture experiment showed that the half-saturation constant and uptake rate of phosphorus were one order lower and seven times higher for M. aeruginosa than those for Cyclotella sp. These findings implied that M. aeruginosa would possess a potential for the growth and survival over Cyclotella sp. in the phosphorus limited condition. The superiority of M. aeruginosa was reflected in the outcome of the mixed-species culture experiment, i.e., dominance of M. aeruginosa, even phosphorus concentration was lowered to 0.01 mg-P/L. Therefore, it could be concluded that the decrease in phosphorus concentration due to the river water dilution to Lake Tega would be interpreted as a minor factor for the transition of dominant species from M. aeruginosa to Cyclotella sp. | Yoshimasa Amano Yusuke Sakai Takumi Sekiya Kimitaka Takeya Kazuo Taki Motoi Machida | 2010 | Journal of Environmental Sciences2010，22，11： | 16 |
| 2 | MDM2和CDK4免疫组化染色可以区分低级别骨肉瘤与其拟似的良性骨病变显示文摘 | Yoshida A Ushiku T Motoi T 黄文斌(摘译) | 2010 | 临床与实验病理学杂志2010，26，5： | 13 |
| 3 | NKX3-1是诊断EWSR1-NFATC2肉瘤和间叶性软骨肉瘤有用的免疫组化标志物显示文摘目前,NKX3-1被普遍认为是前列腺腺癌的高度敏感和特异性标志物。NKX3-1转录组数据提示其mRNA在EWSR1-NFATC2肉瘤中表达上调,为此作者探讨NKX3-1免疫组化在肉瘤诊断中的应用。作者采用免疫组化检测11例EWSR1-NFATC2肉瘤和168例组织学形态相似肿瘤的全组织切片中NKX3-1的表达。11例EWSR1-NFATC2肉瘤均由小圆形或卵圆形细胞构成,除1例外其余至少局部表现为纤维化或黏液样背景下呈典型的巢状、条索状或小梁状生长模式。 | Yoshida K Machado I Motoi T 王婷(摘译) 余英豪(审校) | 2020 | 临床与实验病理学杂志2020，36，11： | 9 |
| 4 | Granular cell tumor of the pancreas:A case report and review of literature显示文摘Granular cell tumors,also called Abrikossof's tumors,were originally described by Abrikossof A in 1926.The f irst case of a pancreatic granular cell tumor was described in 1975 and only 6 cases have been reported.We describe a case of granular cell tumor in the pancreas showing pancreatic duct obstruction.Because imaging studies showed f indings compatible with those of pancreatic carcinoma,the patient underwent distal pancreatectomy.Histological examination showed that the tumor consisted of a nested growth of large tumor cells with ample granular cytoplasm and small round nuclei.The tumor cells expressed S-100 protein and were stained with neuron-specific enolase and periodic acid-Schiff,but were negative for desmin,vimentin,and cytokeratin.The resected tumor was diagnosed as a granular cell tumor.To our knowledge,this is the seventh case of Granular cell tumor of the pancreas to be reported. | Atsushi Kanno Kennichi Satoh Morihisa Hirota Shin Hamada Jun Umino Hiromichi Itoh Atsushi Masamune Shinichi Egawa Fuyuhiko Motoi Michiaki Unno Kazuyuki Ishida Tooru Shimosegawa | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 5 |
| 5 | miR‐197 induces epithelial–mesenchymal transition in pancreatic cancer cells by targeting p120 catenin显示文摘 | Shin Hamada Kennichi Satoh Shin Miura Morihisa Hirota Atsushi Kanno Atsushi Masamune Kazuhiro Kikuta Kiyoshi Kume Jun Unno Shinichi Egawa Fuyuhiko Motoi Michiaki Unno Tooru Shimosegawa | 2013 | J Cell Physiol2013，，6： | 3 |
| 6 | Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis显示文摘We experienced a very rare case of ulcerative colitis (UC) accompanied with analogous lesions in the stomach, duodenum, and ileal J -pouch. Ileal J-pouch anal anastomosis was performed on a 29-year old woman in 1996. Six years later, she was admitted again to our hospital because of epigastralgia, nausea, watery diarrhea and low fever. Based on the results of endoscopic examination, we diagnosed it as pouchitis. Moreover, on hypotonic duodenography, expansion of the duodenal bulb and the descending portion were poor. Kerckring folds disappeared with typical lead-pipe appearance. The pathogenesis of the gastric and duodenal lesion in this patient was similar to that of the colonic lesions of UC. For the gastroduodenal lesions in this patient, symptomatic remission was obtained following administration of crushed mesalazine tablets (1500 mg/d) for 14 d with continuous administration of omeprazole. Firstly we used ciprofloxacin to treat pouchitis. On the fifth day, she got a fever because of catheter infection. In the catheter culture, methicillin-resistant Staphylococcus aureus (MRSA) was detected. Therefore we changed ciprofloxacin to vancomycin hydrochloride (Vancomycin?). Vancomycin was very effective, and the stool frequency dramatically improved in three days. Now she continues to take mesalazine, but her condition is stable and there has been no recurrence of pouchitis. | Hiroki Ikeuchi Kazutoshi Hori Takashi Nishigami Hiroki Nakano Motoi Uchino Mitsuhiro Nakamura Nobuaki Kaibe Masafumi Noda Hidenori Yanagi Takehira Yamamura | 2006 | World Journal of Gastroenterology2006，12，36： | 3 |
| 7 | Long-term efficacy of infliximab maintenance therapy for perianal Crohn’s disease显示文摘AIM:To assess the long-term efficacy of seton drainage with infliximab maintenance therapy in treatment of stricture for perianal Crohn’s disease(CD). METHODS:Sixty-two patients with perianal CD who required surgical treatment with or without infliximab between September 2000 and April 2010 were identified from our clinic’s database.The activities of the perianal lesions were evaluated using the modified perianal CD activity index(mPDAI)score.The primary endpoint was a clinical response at 12-15 wk after surgery as a shortterm efficacy.Secondary endpoints were recurrence as reflected in the mPDAI score,defined as increased points in every major element.The clinical responses were classified as completely healed(mPDAI=0),partially improved(mPDAI score decreased more than 4 points),and failure or recurrence(mPDAI score increased or decreased less than 3 points). RESULTS:There were 43 males and 19 females,of whom 26 were consecutively treated with infliximab after surgery as maintenance therapy.Complete healing was not seen.Failure was seen in 10/36(27.8%) patients without infliximab and 4/26(15.4%)patients with infliximab(P=0.25).Partial improvement was seen in 26/36(72.2%)patients without infliximab and 22/26(88.5%)patients with infliximab(P=0.25). Short-term improvement was achieved in 48/62(77.4%) patients.Although the mPDAI score improved significantly with surgery regardless of infliximab,it decreased more from baseline in patients with infliximab(50.0%) than in those without infliximab(28.6%),(P=0.003). In the long-term,recurrence rates were low regardless of infliximab in patients without anorectal stricture.In patients with anorectal stricture,cumulative recurrence incidences increased gradually and exceeded 40%at 5 years regardless of infliximab.No efficacy of infliximab treatment was found(P=0.97).Although the cumulative rate of ostomy creation was also low in patients without stricture and high in patients with stricture,no protective efficacy was found with infliximab treatment(P =0.6 without stricture,P=0.22 with stricture). CONCLUSION:Infliximab treatment was demonstrated to have short-term efficacy for perianal lesions.Longterm benefit with infliximab was not proven,at least in patients with anorectal stricture. | Motoi Uchino Hiroki Ikeuchi Toshihiro Bando Hiroki Matsuoka Yoshio Takesue Yoshiko Takahashi Takayuki Matsumoto Naohiro Tomita | 2011 | World Journal of Gastroenterology2011，17，9： | 2 |
| 8 | Interminentpneumatic compression is effective in preventing symptomaticp ulmonar yembolism afierthoracicsurgery显示文摘 | haw Nagahiro Akio Andou Motoi Aoe | 2004 | Surg Today2004，34，1： | 1 |
| 9 | Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy显示文摘 | Motoi F Egawa S Rikiyama T | | 0，，04： | 1 |
| 10 | Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity显示文摘 | Ayumi Yoshizaki Kazuhiro Komura Yohei Iwata Fumihide Ogawa Toshihide Hara Eiji Muroi Motoi Takenaka Kazuhiro Shimizu Minoru Hasegawa Manabu Fujimoto Shinichi Sato | 2009 | Journal of Clinical Immunology2009，，2： | 1 |
| 11 | Portal or superior mesenter- ic vein resection in pancreatoduodenectomy for pancreatic head carcinoma显示文摘 | Murakami Y Satoi S Motoi F | 2015 | BrJ Surg2015，102，7： | 1 |
| 12 | Pitfalls of pit pattern diagnosis in ulcerative colitis-associated dysplasia 显示文摘 | Hata KI Watanabe T Motoi T | 2004 | Gastroenterology2004，126，1： | 1 |
| 13 | Intermittent pneumatic compression is effective in preventing symptomatic pulmonary embolism after thoracic surgery 显示文摘 | Itaru Nagahiro Akio Andou Motoi Aoe | 2004 | Surg Today2004，34，1： | 1 |
| 14 | Assessment of cable maintenance technologies for Honshu-Shikoku bridges显示文摘 | Makoto Kitagawa Shuiehi Suzuki Motoi Okuda | 2001 | Journal of bridge engineering2001，1112，： | 1 |
| 15 | Increased Osteocyte Apoptosis during the Development of Femoral Head Osteoneerosis in Sponta-neously Hypertensive Rats 显示文摘 | Motoi SHIBAHARA Keiichiro NISHIDA Hiroshi ASAHARA | 2000 | Acta MedOkayama2000，54，2： | 1 |
| 16 | Accelerated loss of islet β cells in sucrose-fed Goto-Kakizaki rats, a genetic model of noninsulin- dependent diabetes mellitus 显示文摘 | Motoi K Ryu-ichi W Hiroyasu S | 1998 | Am J Pathol1998，153，： | 1 |
| 17 | Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula 'after pancreatico- jejunostomy显示文摘 | Motoi F Egawa S Rikiyama T | 2012 | Br J Surg2012，99，4： | 1 |
| 18 | Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer显示文摘 | Makoto Sunamura Dan G. Duda Maivel H. Ghattas Lucian Lozonschi Fuyuhiko Motoi Jun-Ichiro Yamauchi Seiki Matsuno Shigeki Shibahara Nader G. Abraham | 2003 | Angiogenesis2003，，1： | 1 |
| 19 | Lung adenocarcinoma:modifica-tion of the 2004 WHO mixed subtype to include the major histologicsubtype suggests correlations between papillary and micropapillary ade-nocarcinoma subtypes,EGFR mutations and gene expression analysis显示文摘 | Motoi N Szoke J Riely G J | 2008 | Am J Surg Pathol2008，32，6： | 1 |
| 20 | Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy显示文摘 | Motoi F Egawa S Rikiyama T | 2012 | Br J Surg2012，99，： | 1 |
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