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| 1 | Criteria for the diagnosis and severity stratification of acute pancreatitis显示文摘Recent diagnostic and therapeutic progress for severe acute pancreatitis(SAP)remarkably decreased the casemortality rate.To further decrease the mortality rate of SAP,it is important to precisely evaluate the severity at an early stage,and initiate appropriate treatment as early as possible.Research Committee of Intractable Diseases of the Pancreas in Japan developed simpler criteria combining routinely available data with clinical signs.Severity can be evaluated by laboratory examinations or by clinical signs,reducing the defect values of the severity factors.Moreover,the severity criteria considered laboratory/clinical severity scores and contrastenhanced computed tomography(CE-CT)findings as independent risk factors.Thus,CE-CT scans are not necessarily required to evaluate the severity of acute pancreatitis.There was no fatal case in mild AP diagnosed by the CE-CT severity score,whereas case-mortality rate in those with SAP was 14.8%.Case-mortality of SAP that fulfilled both the laboratory/clinical and the CE-CT severity criteria was 30.8%.It is recommended,therefore,to perform CE-CT examination to clarify the prognosis in those patients who were diagnosed as SAP by laboratory/clinical severity criteria.Because the mortality rate of these patients with SAP is high,such patients should be transferred to advanced medical units. | Makoto Otsuki Kazunori Takeda Seiki Matsuno Yasuyuki Kihara Masaru Koizumi Masahiko Hirota Tetsuhide Ito Keisho Kataoka Motoji Kitagawa Kazuo Inui Yoshifumi Takeyama | 2013 | World Journal of Gastroenterology2013，19，35： | 24 |
| 2 | Consensus of primary care in acute pancreatitis in Japan显示文摘在日本的尖锐胰腺炎的发生正在增加并且每百万张人口从 187 ~ 347 个盒子。盒子命运是 0.2% 为对温和中等,并且 9.0% 为在在 2003 的日本的严重尖锐胰腺炎。在日本的胰腺炎的专家做了与尖锐胰腺炎在病人的早管理集中于实际方面的这个文件。尖锐胰腺炎和严厉层化的正确诊断应该为尖锐胰腺炎的诊断用标准在所有病人被做并且多,因素得分系统尽早由胰的难处理的疾病的研究委员会求婚了。与尖锐胰腺炎诊断的所有病人应该在医院里被管理。血压监视,脉搏和呼吸率,体温,时时尿的体积,和血氧饱和水平在如此的病人的管理是必要的。早精力旺盛的静脉内的水和具有最前的重要性稳定循环动力学。有鸦片剂的足够的疼痛地势也是重要的。在严重尖锐胰腺炎,在一个早阶段的抗菌素的预防静脉内的管理被推荐。一旦尖锐胰腺炎的诊断被证实,朊酶禁止者的管理应该被开始。如果没有肠塞痛并且胃肠的流血的清楚的症状,从早舞台用非肠道的营养喂的肠内的联合被推荐。有严重尖锐胰腺炎的病人应该尽早被转移到 ICU 执行象朊酶的连续地区性的动脉的注入那样的特殊措施禁止者和抗菌素,和连续牙齿过敏过滤。日本政府为难处理的疾病作为关于措施的研究的工程之一为严重尖锐胰腺炎盖住医疗保健开销。 | Makoto Otsuki Masahiko Hirota Shinju Arata Masaru Koizumi Shigeyuki Kawa Terumi Kamisawa Kazunori Takeda Toshihiko Mayumi Motoji Kitagawa Tetsuhide Ito Kazuo Inui Tooru Shimosegawa Shigeki Tanaka Keisho Kataoka Hiromitsu Saisho Kazuichi Okazaki Yosikazu Kuroda Norio Sawabu Yoshifumi Takeyama | 2006 | World Journal of Gastroenterology2006，12，21： | 9 |
| 3 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 4 | Nationwide epidemiological survey of chronic pancreatitis in Japan显示文摘 | Yingsong Lin Akiko Tamakoshi Seiki Matsuno Kazunori Takeda Tetsuo Hayakawa Motoji Kitagawa Satoru Naruse Takashi Kawamura Kenji Wakai Rie Aoki Masayo Kojima Yoshiyuki Ohno | 2000 | Journal of Gastroenterology2000，，2： | 2 |
| 5 | Muhidrug resistance of acute leukemia and a strategy to overcome it显示文摘 | Motoji T Motomura S Wang Y H | 2000 | Int J Hematol2000，72，4： | 1 |
| 6 | Molecular understanding of chronic pancreatitis: a perspective on the future显示文摘 | Satoru Naruse Motoji Kitagawa Hiroshi Ishiguro | 1999 | Molecular Medicine Today1999，，11： | 1 |
| 7 | Up-regulation of telomerase activity in human lymphocytes显示文摘 | Yamada O Motoji T Miziguchi H | 1996 | Biochim Biophys Acta1996，1314，3： | 1 |
| 8 | Nutritional factors and risk of pancreatic cancer: a population-based case-control study based on direct interview in Japan显示文摘 | Yingsong Lin Akiko Tamakoshi Tetsuo Hayakawa Satoru Naruse Motoji Kitagawa Yoshiyuki Ohno | 2005 | Journal of Gastroenterology2005，，3： | 1 |
| 9 | Electromagnetic pulses generated by compression Of granitic rocks and animal behavior显示文摘 | Motoji Ikeya Chihiro | 2000 | Episodes2000，23，4： | 1 |
| 10 | Detection and identification of microcystins in the drinking water of Haimen City , China显示文摘 | Harada K I Motoji O | 1996 | Natural Toxins1996，12，4： | 1 |
| 11 | Detection and identification of microcystins in the drinking water of Haimen city,china显示文摘 | Ken-ichi Harads Motoji Oschikata Hideaki Uchide | 1996 | Natural Toxins1996，，4： | 1 |
| 12 | Trajectory control of incompletely restrained parallel wire-suspended mechanism based on inverse dynamics显示文摘 | Motoji Y Noritaka Y Akira M | 2004 | IEEE transactions on robotics2004，20，5： | 1 |
| 13 | A clinical study of idioathic pulmonary fibrosis based on autopsy studies in elderly patients显示文摘 | Takehiko Araki Hideki Katsura Motoji Sawabe | 2003 | Internal Medicine2003，42，6： | 1 |
| 14 | Inhibition of P-glycoprotein and recovery of drug sensitivity of human acute leukemic blast cells by multidrug resistance gene (mdr1) antisense oligonucleotides显示文摘 | Motomura S Motoji T Takanashi M | 1998 | Blood1998，91，9： | 1 |
| 15 | High-performance liquid chromatography with chemilumi- nescence detection of derivatized microcystins 显示文摘 | Hideaki Murata Hiroko Shoji Motoji Oshikata | 1995 | J Chromatogr A1995，693，2： | 1 |
| 16 | Electric Field Effects on Animals:Mechanism of Seismic Anomalous Animal Behaviors (SAABs)显示文摘Electric field effect on animals has been studied to investigate its relation with seismic anomalous animal behaviors(SAABs)in China.Freshwater eel,crucian carp,catfish,and soft-shelled turtle responded to the threshold electric field of 1-10 V/m,while duck,goose,cat,sheep,pig,dog,and chicken all responded to the ground electric field of about tens of V/m,depending on the species as well as on individuals.Most of the behaviors caused by electric field were similar to those reported as SAABs such as alignment,sudden movement,panic,and convulsion.The intensity of electric field due to a major earthquake would have been over these threshold values.Numerical estimation based on an electromagnetic model of a fault has been made to induce SAABs as electric shocks to pulsed electric fields in electro-physiology.The seismic electric signals(SES)intensity might be estimated from the observation of SAABs. | Huang Qinghua,Ikeya Motoji,and Huang PeihuaDepartment of Earth and Space Sciences,Graduate School of Science,Osaka University,Osaka 560,Japan Department of Earth and Space Sciences,University of Science and Technology of China,Hefei 230026,China | 1997 | Earthquake Research in China1997，11，1： | 1 |
| 17 | Efficacy of right ventricularfree wall longitudinal speckle-tracking strain for predicting longtermoutcome in patients with pulmonary hypertension显示文摘 | Motoji Y Tanaka H Fukuda Y | 2013 | Circ J2013，77，3： | 1 |
| 18 | Multidrug resistance of acute leukemia and a strategy to overcome it 显示文摘 | Motomura S Wang YH | 2000 | Int J Hematol2000，72，4： | 1 |
| 19 | Multidrug resistance of acute leukemia and a strategy to overcome it显示文摘 | Motoji T Motomura S Wang YH | 2000 | Int J Hematol2000，72，4： | 1 |
| 20 | Inhibition of p-glyco-protein and recovery of drug sensitivity of human acute leukemia blasts cells by MDR gene(mdr1) antisense oligonucleotides显示文摘 | Motomura S Motoji T Takanashi M | 1998 | Blood1998，91，9： | 1 |
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