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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Functional proper- ties of Rohu ( Labeo rohita) proteins during iced storage 显示文摘 | Mukund M Dhanya R Sankar T V | 2006 | Food Research International2006，39，8： | 1 |
| 3 | Environmentally compatible next generation green energetic materials (GEMs) 显示文摘 | TalawarM B Sivabalan R MukundanT etal | 2009 | Journal of Hazardous Materials2009，161，： | 1 |
| 4 | Percutaneous release of trigger digit with and withont cortisone injection显示文摘 | Mukund R | 1997 | J Bone Joint Surg Am1997，11，8： | 1 |
| 5 | Novel methylcellulose-grafted-acrylamide/gelatin microspheres for controlled release of nifedipine 显示文摘 | Babu V R Kanth V R Mukund J M | 2010 | Journal of Ap- plied Polymer Science2010，115，6： | 1 |
| 6 | Source attribu- tion of Ambient air toxics and other VOCs in Colombus Ohio 显示文摘 | Mukund R Thomas J K Spicer C W | 1996 | Atmos Environ1996，30，20： | 1 |
| 7 | Turbulent drag reduction using riblets on a supercritical airfoil at transonic speeds显示文摘 | VISWANATH P R MUKUND R | 1995 | AIAA Journal1995，33，5： | 1 |
| 8 | Source attrlbution of ambient air toxics and other VOCs in Colombus Ohie 显示文摘 | Mukund R | 1996 | Atmospheric Environment1996，30，20： | 1 |
| 9 | Source at- tribution of ambient air toxic and other VOCrs in Co-- lumbus, Ohio显示文摘 | MUKUND R KELL T J SPIEER C W | 1996 | Amtospheric Envrionment1996，30，20： | 1 |
| 10 | Source attribution of Ambient air toxics and other VOCs in Colombus Ohio显示文摘 | Mukund R Thomas J K Spicer C W | 1996 | Atmos Environ1996，30，20： | 1 |
| 11 | Source attribution of ambient air toxics and other VOCs in Columbus, Ohio 显示文摘 | Mukund R Kelly T J Spicer CW | 1996 | Atomos Environ1996，30，： | 1 |
| 12 | Environmentally compatible next generation green energetic materials (GEMs)显示文摘 | Talawar M B Sivabalan R MukundanT etal | 2009 | Journal of Hazardous Materials2009，161，： | 1 |
| 13 | Source attribution of ambient air toxic and other VOCs in Columbus, Ohio 显示文摘 | Mukund R Kelly T J Specer C W | 1996 | Atmospheric Environment1996，30，20： | 1 |
| 14 | Concentrations and transformations of hazardous air pollutants显示文摘 | Kelly T J Mukund R Spicer C W | 1994 | Environ Sci Technol1994，28，： | 1 |
| 15 | Spectroscopic characterization of the tungsten and iron-sulfur centers in aldehyde ferredoxin oxidoreductases from two hyperthermophilic archaea显示文摘 | Koehler B P Mukund S Conover R C | 1996 | J Am Chem Soc1996，118，12： | 1 |
| 16 | Source attribution of ambientair toxics and other VOCs in Columbus Ohio显示文摘 | Mukund R Thomas J K Spicer C W | 1996 | Atmospheric Envi-ronment1996，30，20： | 1 |
| 17 | Source attribution of am- bient air toxics and other VOCs in Colombus Ohio显示文摘 | Mukund R Thomas J K Spicer C W | 1996 | Atmos Environ1996，30，20： | 1 |
| 18 | Influence of pH on the solubility and conformational characteristics of muscle pro- teins from mullet (mugil cephalus) 显示文摘 | Mukund Mohan Dhanya R Sankar T V | 2007 | Process Biochemistry2007，，42： | 1 |
| 19 | Percutaneous release of trigger digit with and without cortisone in jection显示文摘 | Mukund R | 1997 | J Hand Surg1997，22，： | 1 |
| 20 | Concentrations and transformations of hazardous air pollutants 显示文摘 | Kelly T J Mukund R Spicer C W | 1994 | Environ Sci Technol1994，28，： | 1 |
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