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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | 临床实践指南应当包含治疗负担显示文摘医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传统指南的建议也是从同样角度提出的。最近的指南会考虑患者的价值观以及指南建议行为的可接受性和可行性,但对治疗负担没有明确规定。这使患者很难根据自己的价值观和能力对治疗做出明智的决定。 | Claudia C Dobler Nathan Harb Catherine A Maguire Carol L Armour Courtney Coleman M Hassan Murad 邓璇(译) 莫云凌(校) | 2019 | 英国医学杂志中文版2019，22，3： | 3 |
| 3 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 4 | The effect of the canal-filled area on the bacterial leakage of oval-shaped canals显示文摘 | De-Deus G Murad C Paciornik S | 2008 | Int Endod2008，41，3： | 1 |
| 5 | Periparbum Cardiomyopathy : a Comprehensive review显示文摘 | Abboud J Murad Y Cheir Scarabelli C | 2007 | Int J Caridol2007，118，3： | 1 |
| 6 | The effect of thickness, pore size and structure of a nanomembrane on the flux and selectivity in reverse osmosis separations: a molecular dynamics study 显示文摘 | Murad S Nitsche L C | 2004 | Chem Phys Lett2004，397，： | 1 |
| 7 | Sealing ability of oval- shaped canals filled using the System B heat source with either gutta-percha or Resilon:an ex vivo study using a polymicrobial leak-age model显示文摘 | De-Deus G Audi C Murad C | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007，104，4： | 1 |
| 8 | Phase Ⅱ trial of the combination of paclitaxel and 5-fluorouracil in the treatment of advanced gastric cancer:a novel,safe,and effective regimen显示文摘 | Murad A M Petroianu A Guimaraes R C | 1999 | Am J Clin Oncol1999，22，6： | 1 |
| 9 | Burden of comorbidities and functional and cognitive impairments in elderly patients at the initial diagnosis of heart failure and their impact on total mortality: the Cardiovascular Health Study 显示文摘 | Murad K Goff D C Morgan T M | 2015 | JACC: Heart Failure2015，3，7： | 1 |
| 10 | Peripartum cardiomyopathy: a comprehensive review显示文摘 | ABBOUD J MURAD Y CHEN-SCARABELLI C | 2007 | Int J Cardiol2007，118，： | 1 |
| 11 | Peripartum cardiomyopathy:a comprehensive review 显示文摘 | Abboud J Murad Y Scarabelli C | 2007 | Int J Caridol2007，118，3： | 1 |
| 12 | Association of HLA-B * 1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population 显示文摘 | Chang C C Too C L Murad S | 2011 | Int J Dermatol2011，50，2： | 1 |
| 13 | Transcript profilingin Candida albicans reveals new cellular functions for the tran-scriptional repressors CaTup1,CaMig1and CaNrg1显示文摘 | Murad AM d'Enfert C Gaillardin C | 2001 | Mol Mi-crobiol2001，42，4： | 1 |
| 14 | Sealing ability of oval-shaped canals filled using the System B heat source with either gutta-percha or Resilon:An ex vivo study using a polymicrobial leakage model显示文摘 | De-Deus G Audi C Murad C | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007，104，4： | 1 |
| 15 | The effect of the canal- filled area on the bacterial leakage of oval-shaped canals 显示文摘 | De-Deus G Murad C Paeiornik S | 2008 | Int Endod J2008，41，8： | 1 |
| 16 | Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol)显示文摘 | Murad KL Mahany KL Brugnara C | 1999 | Blood1999，93，6： | 1 |
| 17 | Peripartum cardiomyopathy:a comprehensive review显示文摘 | Abboud J Murad Y Chen-Scarabelli C | 2007 | Int J Caridol2007，118，3： | 1 |
| 18 | The effect of the canal-filled area on the bacterial leakage of oval-shaped canals 显示文摘 | De-Deus G Murad C Paciornik S | 2008 | Int Endod J2008，41，3： | 1 |
| 19 | Association of HLA-B* 1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population显示文摘 | CHANG C C TOO C L MURAD S | 2011 | Int J Dernatol2011，50，2： | 1 |
| 20 | Phase Ⅱ trial of the combination of Paclitaxel and 5-Fu in the treatment of advanced gastric cancer:a novel,safe,and effective refimen显示文摘 | Murad A M Petroianu A Gmimaraes R C | 1999 | Am J Oncol1999，22，6： | 1 |
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