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| 1 | Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats显示文摘Graphene Oxide(GO)-related hydrogels have been extensively studied in hard tissue repair,because GO can not only enhance the mechanical properties of polymers but also promote osteogenic differentiation of mesenchymal stem cells.However,simple GO-related hydrogels are not ideal for the repair of osteoporotic bone defects as the overactive osteoclasts in osteoporosis.Alendronate(Aln)is known to inhibit osteoclasts and may bind to GO through covalent connection.Therefore,delivering Aln in GO-related hydrogels may be effective to repair osteoporotic bone defects.Here,we developed a control-released system which is constructed by collagen(Col)-GO sponges loaded with Aln(Col-GO-Aln)for osteoporotic bone defect repair.In vitro,Col-GO-Aln sponges prolonged the release period of Aln,and the sponge containing 0.05%(w/v)GO released Aln faster than sponge with 0.2%GO.Furthermore,tartrate-resistant acid phosphatase(TRAP)and F-actin staining demonstrated that Col-GO-Aln sponges effectively inhibited osteoclastogenesis of monocyte-macrophages.In vivo,micro-CT scan showed that the volume of newborn bone in defect site by 0.05%GO sponge was nearly three times larger than that of other groups.Moreover,the CT and histological examinations of rat femur proved that Col-GO-Aln sponges decreased the number of osteoclasts and suppressed the systemic bone loss in osteoporotic rats.These findings reveal that the application of GO as carriers of anti-osteoporosis drugs is a viable treatment for osteoporosis.The results also underscore the potential of GO-related hydrogels with Aln-releasing capacity for bone regeneration in osteoporosis. | Yuyang Zeng Muran Zhou Lifeng Chen Huimin Fang Shaokai Liu Chuchao Zhou Jiaming Sun Zhenxing Wang | 2020 | Bioactive Materials2020，5，4： | 10 |
| 2 | 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and Fox P3显示文摘 | JEFFERY LE BURKE F MURAN | 2009 | Immunol2009，183，9： | 1 |
| 3 | The first occurrence of the schwertmannite in a natural stream environment显示文摘 | SCHWERTMANN U BIGHAM J M MURAN E | 1995 | Eurpean Journal of Mineral1995，7，： | 1 |
| 4 | A full-scale study of the geometric parameters that influence wind loads on low-rise buildings 显示文摘 | Hoxey R P Muran P | 1983 | Journal of Wind Engineering and Industrial Aerodynamics1983，13，： | 1 |
| 5 | Antenatal phe2 nobarbital therapy and neonatal outcome,I:Effect on intracranial hemorrhage显示文摘 | Shankaran S Cepeda E Muran G | 1996 | Pediatrics1996，97，： | 1 |
| 6 | Human eukaryotic elongation factor 1A forms oligomers through specific cysteine residues显示文摘真核细胞的延伸因素 1A (eEF1A ) 是涉及捆绑肌动朊的多功能的蛋白质,切断微导管,激活 phosphoinositol-4 kinase,并且招募 aminoacyl-tRNAs 到核糖体在蛋白质生合成期间。尽管证据显示出 isoform eEF1A1 oligomers 的存在,自我协会的实质的机制仍然保持不清楚。此处,我们发现人的 eEF1A1 能自发地形成 oligomers。明确地,半胱氨酸残余上的 mutagenesis 屏幕证明 Cys 234 为 eEF1A1 oligomerization 是必要的。另外,我们也发现氢过氧化物处理能在房间导致 eEF1A oligomers 的形成。由半胱氨酸代替, eEF1A2 isoform 在氧化环境下面在房间显示了能力到 oligomerize。在摘要,在这研究,我们描绘了 eEF1A1 oligomerization 并且证明特定的半胱氨酸残余为这项 oligomerization 活动被要求。 | Tao Liu Yu Yang Di Wang Yan Xiao Guangshi Du Lei Wu Muran Ding Ling Li Chuanfang Wu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 1 |
| 7 | Has the concept of the therapeutic alliance outlived its usefulness? 显示文摘 | Safran JD Muran JC | 2006 | Psychotherapy2006，，43： | 1 |
| 8 | Ssingle serum progesterone as a screen for ecopic pregnancy: exchanging specificity and sensitivity to obtain optimal test performance显示文摘 | Mccord ML Muran D Buster JE | 1996 | Fertil Steril1996，66，4： | 1 |
| 9 | Single serum progesterone as a screen for ectopic pregnancy:exchanging specificity and sensitivity to obtain optimal test performance 显示文摘 | Muran D Buster JE | 1996 | FertilSteril1996，66，4： | 1 |
| 10 | Spatial Correlation Based Collaborative Medium Access Control in Wireless Sensor Networks 显示文摘 | Muran MC Akyildiz I F | 2006 | IEEE/ ACM Transaction on Networking2006，14，2： | 1 |
| 11 | Use of high hydrostatic pressure and irradiationto eliminate Clostridium sporogenes spores in chicken breast显示文摘 | Crawford Y J Muran E A Olson D G | 1996 | Journal of Food Protection1996，，： | 1 |
| 12 | Levels and patterns of t therapeutic alliance in brief psychotherapy 显示文摘 | Stevens CL Muran J C Safran JD | 2007 | Am J Psychother2007，61，1： | 1 |
| 13 | Antenaral phenobarbital therapy and neonatal outcome, Ⅰ: Effect on intracranial hemorrage 显示文摘 | Shankaran S Cepeda E Muran G | 1996 | Pediatrics1996，97，5： | 1 |
| 14 | Antenatal phe2 nobarbi-taltherapy and neonatal outcome,I:Efect On intracranial hemorrhage显示文摘 | Cepeda E Muran G | 1996 | J Pediatrics1996，97，： | 1 |
| 15 | A Full-Scale Study of the Geometric Parameters That Influence Wind Loads on Low-Rise Buildings显示文摘 | Hoxey R P Muran P | 1983 | Journal of Wind Engineering and Industrial Aerodynamics1983，，13： | 1 |
| 16 | Does IL-17 promote tumor growth? 显示文摘 | Muran ski P Restifo NP | 2009 | Blood2009，114，： | 1 |
| 17 | Square Design of Mountain Cities: A Case Study of Shiyan Broadcasting Media Center Square显示文摘City squares are an important part of urban public spaces and play an important role in improving the quality of urban landscapes. For mountain cities, city squares with mountainous characteristics formed by its special geographical environment, which have more identifiability and uniqueness than that in plain cities, have greater influence on the promotion of city image. Their unique regional cultural characteristics and local customs and practices have shaped the totally different temperament of mountain cities. Based on the dialectical relationship between the square, the landscape and the culture, this paper took Shiyan Broadcasting Media Center Square for example to explore the ideas of landscape design in mountain cities. | YANG Yi TAO Ping YANG Muran | 2019 | Journal of Landscape Research2019，11，2： | 0 |
| 18 | 世界奇特植物大观显示文摘“卧虎藏龙”的植物界有长命百岁的长寿王,有擅长舞蹈的“舞林高手”,有体内流淌着龙之血液的龙血树,还有能起死回生的复活草……一起来看看吧! | Gracie Murane 孙莹(译) | 2010 | 新东方英语.中学生(中英文版)2010，，1： | 0 |
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