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| 1 | Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer显示文摘AIM: To investigate the frequency of seropositivity aga- inst CagA, VacA proteins and to determine their indepen- dent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS: The study was designed as a prospective one from a tertiary referral hospital. Dyspeptic patients who were referred to our endoscopy unit for upper gas- trointestinal endoscopy between June 2003 and March 2004 and diagnosed to have DU or nonulcer dyspepsia (NUD) were included. Biopsies from the antrum and body of the stomach were taken in order to assess the current H pylori status by histology, rapid urease test and culture. Fasting sera were obtained from all patients and H pylori status of all sera was determined by IgG antibo- dies using an enzyme-linked immunosorbent assay (ELI- SA) kit. All seropositive patients were further analysed using Western blot assays detecting IgG antibodies aga- inst CagA and VacA proteins. The χ2 test was used for statistical comparison of the values and age-sex adjusted multiple regression analysis was used to determine the independent effects of CagA and VacA seropositivities on the development of DU. RESULTS: Sixty-three patients with DU and 62 patients with NUD were eligible for the final analysis. Seropositi- vity for anti-CagA was detected in 51 of 62 (82%), andin 55 of 63 (87%) patients with NUD and DU, respec- tively (p = no significance), and seropositivity for anti- VacA was found in 25 of 62 (40% ) and in 16 of 63 (25%) patients, with NUD and DU, respectively. CONCLUSION: These findings suggest that none of the- se virulence factors is associated with the development of DU in the studied Turkish patients with dyspepsia. | Yusuf Erzin Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Ahmet Dirican Murat Tuncer Bekir Kocazeybek | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 2 | Long-Term Outcomes of Percutaneous Nephrolithotomy in 177 Patients With Chronic Kidney Disease: A Single Center Experience显示文摘 | Tolga Akman Murat Binbay Rahmi Aslan Emrah Yuruk Faruk Ozgor Erdem Tekinarslan Ozgur Yazici Yalcin Berberoglu Ahmet Yaser Muslumanoglu | 2012 | The Journal of Urology2012，，1： | 1 |
| 3 | Flexible ureterorenoscopy versus semirigid ureteroscopy for thetreatmentof proximal ureteral stones : a retrospective ccnnparativeanalysis of 124oatients 显示文摘 | KARADAG M ASLAN DEMIR MURAT BAGCIOGLU | 2014 | Endourol Stone Dis2014，1，5： | 1 |
| 4 | Effect of pulsed corticosteroids and tocilizumab on hyperinflammation in COVID-19 patients with acute respiratory distress syndrome显示文摘Objective:To compare the efficacy of pulsed-dose corticosteroids(≥250 mg methylprednisolone,3 days)and tocilizumab in treating COVID-19-related hyperinflammation.Methods:This prospective observational study included RT-PCR positive COVID-19 patients with acute respiratory distress syndrome,who were admitted to the COVID-19 Adult Intensive Care Unit of Prof Dr.Murat Dilmener Emergency Hospital(Istanbul,Turkey)between December 1,2020 and February 28,2021.Clinical,laboratory and radiological examinations were used to diagnose COVID-19 associated hyperinflammation.Three cohort groups were formed:the pulsed-dose corticosteroids group(250 mg methylprednisolone for 3 days),the tocilizumab group(8 mg/day single dose or 400 mg/day for 2 days),and the combined group(pulsed-dose corticosteroid+tocilizumab).The difference in mortality rates among the groups was compared primarily.The most common cause(s)of death was determined.Furthermore,adverse events(secondary infection,acute kidney injury,arrhythmia,gastrointestinal system bleeding)for 28 days were recorded.Results:A total of 60 patients were included in this study,with 20 patients in each group.There was no statistically significant difference between the 3 groups in mortality rates(55%in the pulsed corticosteroid group,60%in the tocilizumab group,50%in the combined group,χ2=0.404,P=0.817).Infectious causes were found to be the most common cause of mortality in all the three groups,and no difference was found between them(χ2=0.404,P=0.817).There was also no difference in the development of adverse events such as secondary infection,acute kidney injury,arrhythmia,and gastrointestinal bleeding among the groups(P>0.05).Conclusions:Corticosteroids can be used instead of tocilizumab to treat hyperinflammation in COVID-19 patients with acute respiratory distress syndrome. | Murat Aslan Mehmet Süleyman Sabaz Rabia Yilmaz Sinan Aşar Yasemin TekdöşŞeker Gülsüm Oya Hergünsel | 2021 | Journal of Acute Disease2021，10，5： | 0 |
| 5 | Ocular findings in children with thalassemia major in Eastern Mediterranean显示文摘AIM: To investigate ophthalmologic findings in children with thalassemia major(TM) and compare the findings with healthy controls. ·METHODS: In a cross-sectional study,43 children with thalassemia major from pediatric hematology outpatient clinics from two university hospitals and age/sex matched 47 healthy children were included in the study. After a complete ophthalmic examination,tear function tests including the Schirmer test,fluorescein tear breakup time(BUT),ultrasound pachymetry,and axial length measurement were performed. Obtained data was recorded for statistical analysis and the values of right eyes were compared between groups. ·RESULTS: The mean best corrected visual acuity was 1.34 ±0.75 in TM and 1.08 ±0.28 in controls. It was found lower than 0.1 logMAR unit in 10(23.2%) children with TM and 2(4.2%) in controls,and the difference was statistically significant(P <0.05). The mean central corneal thickness was 540±26.95 in children with TM and 536.98± 20.45μm in controls(P >0.05). The mean axial length was 22.53±0.50 in TM and 22.57±0.43mm in the control group. The mean Schirmer test score was 19.94±6.91 in TM and 24.22±3.95mm in the control group(P <0.01). The mean BUT score was 9.62 ±1.28 in TM and 9.73 ±0.6s in the control group(P >0.05). ·CONCLUSION: In TM,while corneal thickness,axial length,and BUT are close to controls,the Schirmer scores are less than normal. The study revealed that TM may be affected by the tear function and visual acuity. | Adnan Aksoy Murat Aslankurt Lokman Aslan zlem Gül Mesut Garipard| Oguz elik Seydi Okumus Murat zdemir Gkhan zdemir | 2014 | International Journal of Ophthalmology(English edition)2014，7，1： | 0 |
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