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| 1 | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts显示文摘Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens)used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism. | Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 2 | Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents显示文摘 | Murugaiyah V Chan KL | | 0，，02： | 1 |
| 3 | Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents 显示文摘 | Murugaiyah V Chan KL | 2009 | J Ethnophar- macol2009，124，2： | 1 |
| 4 | Mechanisms of anti- hyperuricemic effect of Phyllanthus niruri and its lig- nan constituents 显示文摘 | MURUGAIYAH V CHAN K L | 2009 | J Ethnopharmacol2009，124，2： | 1 |
| 5 | Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents显示文摘 | Murugaiyah V Chan KL | 2009 | J Eth- nopharmacol2009，124，2： | 1 |
| 6 | Lactation failure in crossbred Sahiwal Friesian cattle 显示文摘 | MURUGAIYAH M RAMAKRISHNAN P OMAR A R | 2001 | J Dairy Res2001，68，2： | 1 |
| 7 | Mechanisms of antihyperurieemic effect of Phyllanthus niruri and its lignan constituents 显示文摘 | Murugaiyah V Chart KL | 2009 | J Ethnopharmacol2009，124，2： | 1 |
| 8 | A method for determination of four lignans in Phyllanthus niruri by a simple high perform- ance liquid chromatography (HPTLC) method with fluores- cence detection 显示文摘 | Murugaiyah V Chan Kit-ham | 2007 | J Chromatogr2007，1154，： | 1 |
| 9 | Hypoglycemic and anti-hyperglycemic study of Ocimum tenuiflorum L.leaves extract in normal and streptozotocin-induced diabetic rats显示文摘Objective:To investigate the antidiabetic activity of Ocimum tenuiflorum L.(O.tenuiflorum) leaves used in the traditional medicine management of diabetes in Malaysia.Methods:O.tenuiflorum leaves were extracted sequentially with hexane,chloroform,ethyl acetate,methanol,and water.The extracts were evaluated in terms of antidiabetic activity by using acute,subcutaneous glucose tolerance,and sub-chronic tests in streptozotocininduced diabetic rats.The extracts were also subjected to phytochemical analyses.Results:With an acute dose(1 g/kg),the methanol extracts showed significant reduction(31%) in fasting blood glucose(FBG) of the streptozotocin-induced diabetic rats.The FBG-decreasing effect of ethyl acetate extract was more rapid than that of the other extracts;the decreasing rates were 20%after 2 h,21%after 3 h,and 8%after 5 and 7 h.After 7 h(31%),the effect of methanol extract on FBG was significantly lower than that of metformin.In the subcutaneous glucose tolerance test,only methanol and hexane extracts showed the similarity of metformin in diabetic rats.After 14 days,the effects of these extracts were similar to those of metformin(63.33%).The total flavonoid and phenolic contents of extracts decreased as the polarity of the extraction solvent increased.Conclusions:The results obtained provide support for a possible use of O.tenuiflorum leaves in managing hyperglycemia and preventing the complications associated with it in type 2 diabetic. | Leila Mousavi Rabeta Mohd Salleh Vikneswaran Murugaiyah Mohd Zaini Asmawi | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，12： | 1 |
| 10 | Novel SNPs in heat shock protein 70 gene and their association with sperm quality traits of Boer goats and Boer crosses显示文摘 | S. Nikbin J.M. Panandam H. Yaakub M. Murugaiyah A.Q. Sazili | 2014 | Animal Reproduction Science2014，，： | 1 |
| 11 | AntihypertLricemic lignans from the leaves of Phyllanthus niruri显示文摘 | Murugaiyah V Chan K L | 2006 | Planta Med2006，72，14： | 1 |
| 12 | Synthesis and molecular modeling study of Cu(Ⅱ) complexes derived from 2-(diphenylmethylene)hydrazinecarbothioamide derivatives with cholinesterase inhibitory activities显示文摘2-amino-5-chlorobenzophenone 和 3-aminobenzophenone (L1L4 ) 的 Thiosemicarbazones 被综合了,他们的 Cu (II ) 建筑群(14 ) 与含铜的氯化物经由协作被负担得起。所有这些混合物被 UVvis 和红外光谱学和 CHN 元素的分析描绘。NMR 光谱学也被使用描绘 ligands。在 vitro 胆碱酯酶,为建筑群(14 ) 的禁止的试金证明 IC50 珍视不到 10 mol/L,与建筑群 1 展出大多数活动, IC50 = 为疼痛和 BuChE 的 2.15 mol/L 和 2.16 mol/L 分别地。分子的建模模拟为与疼痛和 BuChE 受体的建筑群 1 揭示了有约束力的相互作用模板。在 DPPH 试金,建筑群也与他们的父母 ligands 相比在 vitro 抗氧化剂活动更出现了。 | Yi Chen Chan Abdussalam Salhin Mohamed Ali Melati Khairuddean Kooi Yeong Khaw Vikneswaran Murugaiyah Alireza Basiri | 2013 | Chinese Chemical Letters2013，24，7： | 1 |
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