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| 1 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 2 | Nor- malhuman corneal populations evaluated by in vivo scan- ningslit confocal microscopy 显示文摘 | Mustonen RK Mcdonald MB Srivannaboon S | 1998 | Cornea1998，17，： | 1 |
| 3 | The pathogenesis of nephmpathia epidemica: new knowledge and unanswered questions 显示文摘 | Mustonen J Makela S Outinen T | 2013 | Antiviral Res2013，100，3： | 1 |
| 4 | Enhanced thrombin formation and fibrinolysis during Acute Puumala hantavirus infection显示文摘 | LAINE O MAKELA S MUSTONEN | 2010 | Thromb Res2010，126，2： | 1 |
| 5 | Effects of peracetic acid and UV irradiation on the inactivation of coliphages in wastewater显示文摘 | Rajala Mustonen R L Toivola P S Heinonen Tanski H | 1997 | Water Sci Technol1997，35，11： | 1 |
| 6 | Normal human corneal cell populations evaluated by in vivo scanning slit confocal microscopy 显示文摘 | Mustonen RK McDonald MB Srivannaboon S | 1998 | Cornea1998，17，： | 1 |
| 7 | Odour andflavour perception in flavoured model systems : Influence of sodiumchloride, umami compounds and serving temperature 显示文摘 | Ventanas S Mustonen S Puolanne E Tuorila H | 2010 | FoodQuality and Preference2010，21，5： | 1 |
| 8 | Normal human cell populations evaluated by in vivo scanning slit confocal microscopy显示文摘 | Mustonen RK McDonald MB Srivannaboon S | 1998 | Cornea1998，17，： | 1 |
| 9 | In vivo confocal microscopy of Fuchs' endothelial dystrophy显示文摘 | Mustonen RK McDonald MB Srivannaboon S | 1998 | Cornea1998，17，： | 1 |
| 10 | Odour and flavour perception in flavoured model systems: Influence of sodium chloride, umami compounds and serving temperature 显示文摘 | Ventanas S Mustonen S Eero Puolanne E Hely Tuorila H | 2010 | Food Quality and Preference2010，21，5： | 1 |
| 11 | Ion chroma-tographic method for the determination of selected inorganic anions and organic acids from raw and drinking waters us-ing suppressor current switching to reduce the backgr-ound noise显示文摘 | Rantakokko P Mustonen S Yritys M | 2004 | Journal of Liquid Chromatography & Re-lated Technologies2004，27，5： | 1 |
| 12 | Acute knee trauma:analysis of multidetector computed tomography findings and comparison with conventional radiography显示文摘 | Mustonen A O Koskinen S K Kiuru M J | 2005 | Acta Radiol2005，46，8： | 1 |
| 13 | Normal human corneal cell population evaluated by in vivo scanning slit confocal microscopy显示文摘 | Mustonen RK McDonald MB Srivannaboon S | 1998 | Cornea1998，17，5： | 1 |
| 14 | Normal hu-man comeal cell populations evaluated by in vivo scanning slitconfocal microscapy 显示文摘 | Mustonen RK Mcdonald MB Srivannaboon S | 1998 | Cornea1998，17，： | 1 |
| 15 | Distribution of radiation induced exchange aberrations in human chromosome 1, 2 and 4显示文摘 | Luomahaara S Lindholm C Mustonen R | 1999 | Int J Radiat Biol1999，75，12： | 1 |
| 16 | Enhanced thrombin for- mation and fibrinolysis during Acute Puumala hantavirus in-fec- tion显示文摘 | Laine O M:i kelfi S Mustonen J | 2010 | Thromb Res2010，126，2： | 1 |
| 17 | Normalhuman corneal cell populations evaluated by in vivo scanningslit confocal microscopy 显示文摘 | Mustonen R K Mcdonald M B Srivannaboon S | 1998 | Cornea1998，17，5： | 1 |
| 18 | Human leukocyte antigen - B8 - DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor - alpha( - 308) G/A polymorphism显示文摘 | Makela S Mustonen J Ala- Houhala I | 2002 | J Infect Dis2002，186，6： | 1 |
| 19 | Adaptations to fasting in a terrestrial mustelid, the sable (Mattes zibellina)显示文摘 | Mustonen A M Puukka M Saarela S | 2006 | Comp Biochem Physiol A Mol Integr Physiol2006，144，： | 1 |
| 20 | Enhanced thrombin forma- tion and fibrinolysis during acute Puumala hantavirus infection 显示文摘 | Laine O Makeli S Mustonen J | 2010 | Thromb Res2010，126，2： | 1 |
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