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| 1 | Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice显示文摘非酒精的脂肪肝疾病(NAFLD ) 是新陈代谢的症候群的肝的表明并且包括肝的脂肪变性, steatohepatitis,和纤维变性的一个系列。Interleukin-17 (IL-17 ) 被报导了在一些肝疾病的煽动性的前进起一个关键作用。现在的学习被设计在 C57BL/6 老鼠在高胖的导致食谱的 NAFLD 上调查 IL-17 的角色。有 anti-IL-17mAb 的 IL-17 封锁 signicantly 改进了肝功能,稀释了肝的类脂化合物累积,压制了 Kuffer 房间激活,并且减少支持 inflammatory cytokines 铺平激活,它与表明串联的 NF-B 的抑制被联系。我们的数据建议 IL-17 与在 NAFLD 老鼠模型的疾病前进有关,堵住 IL-17 可以是为有 NAFLD 的病人的一条有希望的新奇治疗学的途径。 | Renfan Xu Anyu Tao Shasha Zhang Muxun Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 11 |
| 2 | Social vocalizations of big-footed myotis(Myotis macrodactylus)during foraging显示文摘Acoustic signals play a crucial role in transmitting information and maintaining social stability in gregarious animals,especially in echolocating bats,which rely primarily on biological sonar for navigating in the dark.In the context of foraging without relying on tactile,visual or olfactory cues,acoustic signals convey information not only on food but also on ownership and defense of resources.However,studies on such information remain fragmentary.In the present study,we aim to document the social vocal repertoire of Myotis macrodactylus at natural foraging sites.Multiple acoustic analyses and spectrographic classification revealed a rich foraging vocal repertoire comprising 6 simple syllables and 2 composites.Discriminant function analyses associated with a subset-validation procedure provided an optimal method to spectrographically classify all recorded sounds into different syllable types.Multidimensional scaling of median values of multiple parameters further confirmed notable differences among these syllables in a 3-D space.In addition,Euclidean distance analysis showed that there were some spectral similarities between specific social vocal syllables and feeding buzzes,which implied a potential jamming role.Altogether,the data indicate that bats at foraging sites under natural conditions used variant social vocalizations with different functions in addition to echolocation calls,providing supporting evidence for further work on the function and vocal mechanisms of acoustic communication in mammals. | Dongge GUO Bo LUO Kangkang ZHANG Muxun LIU Walter METZNER Ying LIU Jiang FENG | 2019 | Integrative Zoology2019，14，5： | 1 |
| 3 | Tum or Necrosis Factor Expression in ArterialWallsof Diabetic Rats显示文摘Immunohistochemistry was used to detect tumor necrosis factor (TNF α) expression in arterial wall of diabetic rats. It was found that endothelial cells were swollen and markedly proliferative in these vessels and accordingly TNF α showed strong positive immunohistochemical reaction in endothelial cells or extracellular intimal matrix of such vessels, which might be caused by the expression and release of TNF α from monocytes and arterial wall cells stimulated by AGEs. These findings suggested that increased TNF α expression might be associated with vascular damage and remodeling in diabetes. | ZHANG Muxun, REN Dahong LI Xu ZHANG Jianhua Department of Endocrinology, Tongji Hospital, Tongji Medical University, Wuhan 430030 * Department of Pathology, School of Basic Medical Sciences, Tongji Medical University, Wuhan 430030 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 1 |
| 4 | Re search on accuracy improvement of holospectrum tech nique in machine tool spindle显示文摘 | Zhang Yun Zhang Dongsheng Xu Muxun | 2011 | Advances in Com munication Technology2011，4，： | 1 |
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