|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 2 | Somatic Embryogenesis Receptor Kinases Control Root Development Mainly via Brassinosteroid-Independent Actions in Arabidopsis thaliana显示文摘Brassinosteroids(BRs),a group of plant steroidal hormones,play critical roles in many aspects of plant growth and development.Previous studies showed that BRI1-mediated BR signaling regulates cell division and differentiation during Arabidopsis root development via interplaying with auxin and other phytohormones.Arabidopsis somatic embryogenesis receptor-like kinases(SERKs),as co-receptors of BRI1,were found to play a fundamental role in an early activation step of BR signaling pathway.Here we report a novel function of SERKs in regulating Arabidopsis root development.Genetic analyses indicated that SERKs control root growth mainly via a BR-independent pathway.Although BR signaling pathway is completely disrupted in the serk1 bak1 bkk1 triple mutant,the root growth of the triple mutant is much severely damaged than the BR deficiency or signaling null mutants.More detailed analyses indicated that the triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport,cell cycle,endodermis development and root meristem differentiation,which were not observed in null BR biosynthesis mutant cpd and null BR signaling mutant bri1-701. | Junbo Du Hongju Yin Shasha Zhang Zhuoyun Wei Baolin Zhao Jinghua Zhang Xiaoping Gou Honghui Lin Jia Li | 2012 | Journal of Integrative Plant Biology2012，54，6： | 22 |
| 3 | Design and indoor simulated experiment of pneumatic rice seed metering device显示文摘In order to meet the agronomy demand for hybrid rice direct seeding,a novel precise pneumatic rice seed metering device was designed with groups of sucking holes plate,by which 3-4 seeds could be synchronously sucked and synchronously dropped into the paddy field.The plate was divided into five sections:seed sucking,seed clearing,seed carrying,seed dropping,and blank sections.The seeds were sucked in sucking section by the vacuum,carried and rotated to the dropping section with the plate,blown away in dropping section by the positive pressure air,and thrown into the dropping tube.The influences of the hole diameter,vacuum degree,and clear-up equipment on precision of metering device were discussed.Experiments were conducted to investigate the seeding precision and simulate the field emergence rates on the indoor seeding test-bed.The subjects were pregnant Indic hybrid Peizataifeng under two kinds of moisture content(23.43%and 26.07%).Other experiment conditions included the vacuum degree of 2.60 kPa,the rotation speed of seed sucking plate of 30 r/min,three sucking holes with a diameter of 1.6 mm,and the seed layer thickness of 25 mm.The seeding results showed that,in condition of no more than two seeds per hill,the emergence probabilities under the two moisture contents were 11.82%and 11.95%,respectively,and in condition of 3-4 seeds per hill,the results were 64.81%and 65.84%,respectively.With 2-5 seeds per hill,the results were 92.08%and 92.60%,respectively.If the emergence probability was 80%,under the two moisture contents,the no seed per hill probabilities were 1.33%and 0.80%respectively;the probabilities with 3-4 seeds per hill were 56.13%and 56.40%respectively;the probabilities with 5 or more seeds per hill were 10.67%and 10.13%respectively;the probabilities with 2-5 seeds per hill were 87.60%and 88.13%respectively.The results showed the simulated experiment was an efficient and economic method to assess the capability of pneumatic rice seed drilling metering device,and the precise pneumatic rice seed drilling metering device had a good prospect in practical application. | Zhang Guozhong Zang Ying Luo Xiwen Wang Zaiman Zhang Qiang Zhang Shasha | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 19 |
| 4 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 5 | Scalable production of self-supported WSe/CNFs by electrospinning as the anode for high-performance lithium-ion batteries显示文摘 | Shasha Zhou Junnian Chen Lin Gan Qing Zhang Zhi Zheng Huiqiao Li Tianyou Zhai | 2016 | Science Bulletin2016，61，3： | 11 |
| 6 | Recent development of a refined multiple air pollutant emission inventory of vehicles in the Central Plains of China显示文摘Central Plains region of China,represented by Henan Province,is facing serious air pollution problems.Vehicular exhaust emissions had adverse impacts on the atmospheric environment.The first comprehensive and novel vehicle emission inventory for Henan Province using vehicle kilometers traveled,localized emission factors,and activity data at city-level was developed.Furthermore,3 km×3 km gridded emission and temporal variations were determined by using localized information.Results show that the total emissions of sulfur dioxide(SO2),nitrogen oxides(NOx),carbon monoxide(CO),particular matter with aerodynamic diameter<10μm(PM10),aerodynamic diameter<2.5μm(PM2.5),volatile organic compounds(VOCs),VOCs-evaporation and ammonia in 2015 were 9.1,533.4,1190.7,23.7,21.6,150.8,31.5 and 10.4 Gg,respectively,and the emission intensities of the above pollutants were 0.05,2.7,6.0,0.1,0.1,0.8,0.2 and 0.05 g/km,respectively.Vehicles meeting the Primary China 1,China 3 and China 4 contributed 89.1%,82.7%,75.3%,75.5%,75.5%,68.2%,68.4%and 82.3%for SO2,NOx,CO,PM10,PM2.5,VOCs,VOCs-evaporation and ammonia emissions,respectively.Zhengzhou,Zhoukou,Nanyang,Luoyang,Shangqiu and Xinyang showed relatively higher emissions and contributed more than 50%of each pollutant.The spatial distribution indicated obvious characteristics of the road network,and high-level emission was concentrated in the downtown areas.Additionally,the ozone formation potential(OFP)based on the estimated speciated VOC emissions was 569.6 Gg in Henan Province.Aliphatic and aromatic hydrocarbons were the main species of VOCs,whereas olefins contributed the largest proportion of OFP,with 42.2%. | Xingke Gu Shasha Yin Xuan Lu Huan Zhang Lingling Wang Ling Bai Chen Wang Ruiqin Zhang Minghao Yuan | 2019 | Journal of Environmental Sciences2019，31，10： | 11 |
| 7 | Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice显示文摘非酒精的脂肪肝疾病(NAFLD ) 是新陈代谢的症候群的肝的表明并且包括肝的脂肪变性, steatohepatitis,和纤维变性的一个系列。Interleukin-17 (IL-17 ) 被报导了在一些肝疾病的煽动性的前进起一个关键作用。现在的学习被设计在 C57BL/6 老鼠在高胖的导致食谱的 NAFLD 上调查 IL-17 的角色。有 anti-IL-17mAb 的 IL-17 封锁 signicantly 改进了肝功能,稀释了肝的类脂化合物累积,压制了 Kuffer 房间激活,并且减少支持 inflammatory cytokines 铺平激活,它与表明串联的 NF-B 的抑制被联系。我们的数据建议 IL-17 与在 NAFLD 老鼠模型的疾病前进有关,堵住 IL-17 可以是为有 NAFLD 的病人的一条有希望的新奇治疗学的途径。 | Renfan Xu Anyu Tao Shasha Zhang Muxun Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 11 |
| 8 | Characteristics,sources and health risks assessment of VOCs in Zhengzhou,China during haze pollution season显示文摘Zhengzhou is one of the most haze-polluted cities in Central China with high organic carbon emission,which accounts for 15%-20%of particulate matter(PM_(2.5))in winter and causes significantly adverse health effects.Volatile organic compounds(VOCs)are the precursors of secondary PM_(2.5)and O_(3)formation.An investigation of characteristics,sources and health risks assessment of VOCs was carried out at the urban area of Zhengzhou from 1^(st) to 31^(st) December,2019.The mean concentrations of total detected VOCs were 48.8±23.0 ppbv.Alkanes(22.0±10.4 ppbv),halocarbons(8.1±3.9 ppbv)and aromatics(6.5±3.9 ppbv)were the predominant VOC species,followed by alkenes(5.1±3.3 ppbv),oxygenated VOCs(3.6±1.8 ppbv),alkyne(3.5±1.9,ppbv)and sulfide(0.5±0.9 ppbv).The Positive Matrix Factorization model was used to identify and apportion VOCs sources.Five major sources of VOCs were identified as vehicular exhaust,industrial processes,combustion,fuel evaporation,and solvent use.The carcinogenic and non-carcinogenic risk values of species were calculated.The carcinogenic and non-carcinogenic risks of almost all air toxics increased during haze days.The total non-carcinogenic risks exceeded the acceptable ranges.Most VOC species posed no non-carcinogenic risk during three haze events.The carcinogenic risks of chloroform,1,2-dichloroethane,1,2-dibromoethane,benzyl chloride,hexachloro-1,3-butadiene,benzene and naphthalene were above the acceptable level(1.0×10^(-6))but below the tolerable risk level(1.0×10^(-4)).Industrial emission was the major contributor to non-carcinogenic,and solvent use was the major contributor to carcinogenic risks. | Dong Zhang Bing He Minghao Yuan Shijie Yu Shasha Yin Ruiqin Zhang | 2021 | Journal of Environmental Sciences2021，33，10： | 10 |
| 9 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 10 | NKT cells in liver diseases显示文摘 | Shasha Zhu Huimin Zhang Li Bai | 2018 | Frontiers of Medicine2018，12，3： | 9 |
| 11 | Identification and fine mapping of two blast resistance genes in rice cultivar 93-11显示文摘Rice blast, caused by Magnaporthe oryzae, is a major disease of rice almost worldwide. The Chinese indica cultivar 93-11 is resistant to numerous isolates of the blast fungus in China, and can be used as broad-spectrum resistance resource, particularly in japonica rice breeding programs. In this study, we identified and mapped two blast resistance genes, Pi60(t) and Pi61(t), in cv. 93-11 using F2 and F3 populations derived from a cross between the susceptible cv. Lijiangxintuanheigu(LTH) and resistant cv. 93-11 and inoculated with M. oryzae isolates from different geographic origins. Pi60(t) was delimited to a 274 kb region on the short arm of chromosome 11, flanked by InDel markers K1-4 and E12 and cosegregated with InDel markers B1 and Y10. Pi61(t) was mapped to a 200 kb region on the short arm(near the centromere) of chromosome 12, flanked by InDel markers M2 and S29 and cosegregating with InDel marker M9. In the 274 kb region of Pi60(t), 93-11 contains six NBS-LRR genes including the two Pia/ PiCO39 alleles(BGIOSGA034263 and BGIOSGA035032) which are quite close to the two Pia/ PiCO39 alleles(SasRGA4 and SasRGA5) in Sasanishiki and CO39, with only nine amino acids differing in the protein sequences of BGIOSGA035032 and SasRGA5. In the 200 kb region of Pi61(t), 93-11 contains four NBS-LRR genes, all of which show high identities in protein sequence with their corresponding NBS-LRR alleles in susceptible cv. Nipponbare. Comparison of the response spectra and physical positions between the target genes and other R genes in the same chromosome regions indicated that Pi60(t) could be Pia/PiCO39 or its allele, whereas Pi61(t) appears to be different from Pita, Pita-2, Pi19(t), Pi39(t) and Pi42(t) in the same R gene cluster. DNA markers tightly linked to Pi60(t) and Pi61(t) will enable marker-assisted breeding and map-based cloning. | Cailin Lei Kun Hao Yilong Yang Jian Ma Shuai Wang Jiulin Wang Zhijun Cheng Shasha Zhao Xin Zhang Xiuping Guo Chunming Wang Jianmin Wan | 2013 | The Crop Journal2013，1，1： | 8 |
| 12 | Topographical relief characteristics and its impact on population and economy:A case study of the mountainous area in western Henan,China显示文摘Topographical relief is a key factor that limits population distribution and economic development in mountainous areas.The limitation is especially apparent in the mountain?plain t「ansition zone.Taking the transition zone between the Qinling Mountains and the North China Plain(i.e.the mountainous area in western Henan Province)as an example and based on the 200-m resolution DEM data,we used the mean change-point analysis to determine the optimal statistical unit for topographical relief,and thereafter extracted the relief degree.Taking the 1:100,000 land use data,township population and county-level industrial data,population and economic spatial models were constructed,and 200?m resolution grid population and economic density maps were gen erated.Afterwards,statistical analysis was carried out to quantitatively reveal the impact of topographical relief on population and economy.In addition,the impacts of other topographical factors were discussed.The results showed the following.(1)The relief degree in western Henan is generally low,where 58.6%of the regional topography does not exceed half the height of a reference mountain(relative elevation W250 m).Spatially,the relief degree is high in the west while low in the east,and high in the middle while low in the north and south.There is a positive correlation between relief degree and elevation,and a much stronger correlation between relief degree and slope.(2)The linear fitting degree between the population and economic validation data and the corresponding simulation data are 0.943 and 0.909,respectively,indicating that the spatialized results can reflect the actual population and economic distribution.(3)The impact of topographical relief on population and economy was stronger than that of other topographical factors.The relief degree showed a good logarithmic fit relati on ship with population density(0.911)and economic density(0.874).Specifically,88.65%of the population lives in areas where the topographical relief is W0.5 and 88.03%of the gross regional product was from areas where the relief is W0.3.Compared with the population distribution,the economic development showed an obvious agglomeration trend towards low relief areas. | ZHANG Jingjing ZHU Wenbo ZHU Lianqi CUI Yaoping HE Shasha REN Han | 2019 | Journal of Geographical Sciences2019，29，4： | 8 |
| 13 | Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea显示文摘在内耳的感觉毛细胞为健全识别负责。因为这些房间不能再生,在成年哺乳动物的毛细胞的损坏引起永久听觉缺陷。由对比,因为各种各样的发信号的小径的活跃参予,新生的哺乳动物拥有有限再生能力,包括 Wnt 并且槽口发信号。Wnt 和槽口小径高度复杂、保存表明控制为感觉毛细胞的形成必要的多重细胞的事件的小径。两个都发信号的小径允许支持房间在新生的蜗改革毛细胞的居民。在这方面, Wnt 并且槽口发信号在毛细胞新生获得了增加的研究注意。这评论在内耳的听觉的部分介绍 Wnt 和槽口发信号小径的当前的理解并且讨论与毛细胞命运限定词 Atoh1 控制这些小径在哺乳动物的蜗调整毛细胞新生的可能性。 | Muhammad Waqas Shasha Zhang Zuhong He Mingliang Tang Renjie Chai | 2016 | Frontiers of Medicine2016，10，3： | 7 |
| 14 | Spatiotemporal characterization and regional contributions of O3 and NO2:An investigation of two years of monitoring data in Henan,China显示文摘To investigate the characteristics of ground level ozone(O3)for Henan Province,the ambient air quality monitoring data of 2015 and 2016 were analyzed.The result showed that the 8 h-max-O3 concentrations displayed a distinct seasonality,where the maximum and minimum values,averaging 140.41,54.19μg/m3,occurred in summer and winter,respectively.There is a significant correlation between meteorological factors and O3 concentration.The Voronoi neighborhood averaging analysis indic ated that O3,temperature,and ultraviolet radiation in Henan province were decreased from northwest to southeast,while relative humidity and precipitation displayed the opposite trend.Besides meteorological factors,the chemical processes play an essential role in ozone formation.Reactions of NO,NO2 and O3 form a closed system,and the partitioning point of the OX-component(O3+NO2)was at 40 and 80μg/m3 for nitrogen oxide(NOx)in winter and summer,respectively,with NO2 dominating at higher NOx pollution and O3 being the m ajor component at lower levels.The relationship between oxidant(OX=O3+NO2)and NOx concentrations were evaluated to understand the regional and local contribution of OX.It showed that high regional contribution occurred in the spring,whereas the highest local contribution lead to the summer peak of O3 observed in Zhengzhou.This present study reveals important environment impacts from the photochemical process and the meteorological conditions in the region with better understanding on the O3 characterization. | Shijie Yu Shasha Yin Ruiqin Zhang Lingling Wang Fangcheng Su Yixiang Zhang Jian Yang | 2020 | Journal of Environmental Sciences2020，32，4： | 7 |
| 15 | Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI. | Yifei Cheng Yuhong Chen Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu Xiaohui Zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang | 2019 | Engineering2019，5，1： | 7 |
| 16 | The rising star in photovoltaics-perovskite solar cells: The past, present and future显示文摘Perovskite solar cell(PVSC), after its invention since 2009, has attracted tremendous attention from both academia and industry, because of its low cost, ease of manufacturing features and the sky-rocketing efficiencies being achieved within such a short period of time. Currently, the new efficiency record has reached 21.0%, comparable to that of the commercialized PV technologies developed for decades, such as multi-crystalline Si, CIGS and Cd Te thin film solar cells. It is very possible that PVSCs would one day step over the threshold of marketization, share or even overturn the current PV market dominated by crystalline-Si solar cells. However, there are still several obstacles to be overcome on the road towards PVSC industrialization. This paper has reviewed the brief developing history and the current research status of PVSCs, and explained: Why PVSCs are so important in the next-generation solar cells, why organometal halide perovskites work so well as light absorbers, and what the inherent differences are among different cell configurations. The prospects on how to realize scale-up industrialization of PVSCs have also been given in the sequence of efficiency, stability, cost, toxicity, and short-term objectives. Resolutions to the remaining challenges according to their orders of technical difficulty and importance have also been discussed. | FANG Rui ZHANG WenJun ZHANG ShaSha CHEN Wei | 2016 | Science China(Technological Sciences)2016，59，7： | 6 |
| 17 | Radial Distribution of SiC Particles in Mechanical Stirring of A356-SiC_p Liquid显示文摘The mechanical stirring of A356-2.5 vol.% SiC p liquid was conducted in a cylindrical crucible by a straightblade stirrer.The radial distribution of SiC particles in A356 liquid was studied under the conditions of 25 deg.for gradient angle α of blade and 10 mm/s for speed of moving up and down of stirrer.The results show that there exists a nonlinear relationship between rotating speed of stirrer and radial relative deviation of SiC p content in A356 liquid between the center and the periphery of crucible.The greater the rotating speed of stirrer is,the bigger the radial relative deviation of SiC p content in A356 liquid becomes and the more nonhomogeneous the radial distribution of SiC particles in A356 liquid turns.In addition,when the rotating speed of stirrer is about 200 r/min,the vertical distribution of SiC particles in A356 liquid is relative uniform.It can be seen that the nonhomogeneous distribution of SiC particles in A356 liquid results from the nonhomogeneous radial distribution of SiC particles in A356 liquid in straight-blade mechanical stirring ultimately. | Yunhui Du Peng Zhang Jun Zhang Shasha Yao | 2012 | Journal of Materials Science & Technology2012，28，10： | 5 |
| 18 | Diagenesis and Diagenetic Evolution of Deltaic and Neritic Gas-Bearing Sandstones in the Lower Mingyuefeng Formation of Paleogene, Lishui Sag, East China Sea Shelf Basin: Implications for Depositional Environments and Sequence Stratigraphy Controls显示文摘Gas-bearing deposits in the Lower Mingyuefeng Formation of Paleogene, Lishui Sag, East China Sea Shelf Basin consist of shoreface sandstones of the highstand systems tract(HST) and transgressive systems tract(TST), and deltaic sandstones of the lowstand systems tract(LST) and falling stage systems tract(FSST).Detailed petrographic observations suggest that the diagenetic features and related evolution of these deposits cannot be simply characterized and demonstrated in the depth domain.However, the occurrence of diagenetic minerals systematically depends on the studied interval within the HST, TST, LST, and FSST; therefore, diagenesis in this region can be better constrained when studied in the context of the depositional environments and sequence stratigraphic framework.The eogenetic processes in such settings include:(1) microcrystalline siderite precipitated as concretions in almost all environments and systems tracts, which inhibited further mechanical compaction;(2) grain dissolution and kaolinitization occurred in shoreface HST sandstones and deltaic LST and FSST sandstones;(3) glaucony was locally observed, which did not clearly reflect the controls of facies or sequence stratigraphy; and(4) cementation by pyrite aggregates occurred in the shoreface HST sandstones and deltaic LST sandstones.The mesogenetic diagenesis includes:(1) partial conversion of kaolinite into dickite in deltaic LST sandstones, and minor chlorite cementation in deltaic FSST sandstones;(2) transformation of kaolinite into illite and quartz cementation in deltaic LST and FSST sandstones;(3) frequent precipitation of ankerite and ferroan calcite in shoreface TST sandstones and early HST sandstones, forming baffles and barriers for fluid flow, with common calcite in shoreface HST sandstones as a late diagenetic cement; and(4) formation of dawsonite in the deltaic LST and FSST sandstones, which is interpreted to be a product of the invasion of a CO2-rich fluid, and acts as a good indicator of CO2-bearing reservoirs.This study has thus constructed a reliable conceptual model to describe the spatial and temporal distribution of diagenetic alterations.The results may provide an entirely new conceptual framework and methodology for successful gas exploration in the continental margins of offshore China, thus allowing us to predict and unravel the distribution and quality evolution of clastic reservoirs at a more detailed and reliable scale. | XU Fa ZHANG Penghui ZHANG Jinliang LIU Jinshui HOU Guowei ZHANG Ming LI Jingzhe LIU Shasha GUO Jiaqi MENG Ningning | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 5 |
| 19 | Phytochrome B and AGB1 Coordinately Regulate Photomorphogenesis by Antagonistically Modulating PIF3 Stability in Arabidopsis显示文摘Phytochrome B (phyB), the primary red light photoreceptor, promotes photomorphogenesis in Arabidopsis by interacting with the basic helix-loop-helix transcriptional factor PIF3 and inducing its phosphorylation and degradation. Heterotrimeric G proteins are known to regulate various developmental processes in plants and animals. In Arabidopsis, the G-protein β subunit AGB1 is known to repress photomorphogenesis. However, whether and how phyB and AGB1 coordinately regulate photomorphogenesis are largely unknown. Here we show that phyB physically interacts with AGB1 in a red light-dependent manner and that AGB1 interacts directly with PIF3. Moreover, we demonstrate that the AGB1-PIF3 interaction inhibits the association of PIF3 with phyB, leading to reduced phosphorylation and degradation of PIF3, whereas the phyB-AGB1 interaction represses the association of PIF3 with AGB1, resulting in enhaneed phosphorylation and degradation of PIF3. Our results suggest that phyB and AGB1 antagonistically regulate PIF3 stability by dynamically interacting with each other and PIF3. This dynamic mechanism may allow plants to balanee phyB and G-protein signaling to optimize photomorphogenesis. | Pengbo Xu Hongli Lian Feng Xu Ting Zhang Sheng Wang Wenxiu Wang Shasha Du Jirong Huang Hong-Quan Yang | 2019 | Molecular Plant2019，12，2： | 5 |
| 20 | NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma显示文摘Objective:Esophageal squamous cell carcinoma(ESCC)has high morbidity and mortality rates worldwide.Cancer stem cells(CSCs)may cause tumor initiation,metastasis,and recurrence and are also responsible for chemotherapy and radiotherapy failures.Myeloid-derived suppressor cells(MDSCs),in contrast,are known to be involved in mediating immunosuppression.Here,we aimed to investigate the mechanisms of interaction of CSCs and MDSCs in the tumor microenvironment.Methods:ESCC tissues and cell lines were evaluated.Neural precursor cell expressed,developmentally downregulated 9(NEDD9)was knocked down and overexpressed by lentiviral transfection.Quantitative PCR,Western blot,immunohistochemistry,cell invasion,flow cytometry,cell sorting,multiplex chemokine profiling,and tumor growth analyses were performed.Results:Microarray analysis revealed 10 upregulated genes in esophageal CSCs.Only NEDD9 was upregulated in CSCs using the sphere-forming method.NEDD9 expression was correlated with tumor invasion(P=0.0218),differentiation(P=0.0153),and poor prognosis(P=0.0373).Additionally,NEDD9 was required to maintain the stem-like phenotype.Screening of chemokine expression in ESCC cells with NEDD9 overexpression and knockdown showed that NEDD9 regulated C-X-C motif chemokine ligand 8(CXCL8)expression via the ERK pathway.CXCL8 mediated the recruitment of MDSCs induced by NEDD9 in vitro and in vivo.MDSCs promoted the stemness of ESCC cells through NEDD9 via the Notch pathway.Conclusions:As a marker of ESCC,NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor,suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC. | Dongli Yue Shasha Liu Tengfei Zhang Yong Wang Guohui Qin Xinfeng Chen Huanyu Zhang Dong Wang Lan Huang Feng Wang Liping Wang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员