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| 1 | Autophagy modulation as a target for anticancer drug discovery显示文摘Autophagy,包含非本质或反常的细胞的细胞器和蛋白质的吞没和降级的一个 evolutionarily 保存的分解代谢的过程,为在生活房间的 homeostatic 维护是关键的。这高度调整了,多步过程包括癌症在多样的疾病被含有。Autophagy 能作为一个倡导者或癌症的 suppressor 工作,它使它成为一个有希望、挑战性的治疗学的目标。此处,我们概述规章的机制和在癌症的 autophagy 的双角色。我们也描述一些由调整 autophagy 施加他们的 anticancer 效果的代表性的代理人。另外,新兴的策略在 modulating autophagy 瞄准了的一些作为为未来 anticancer 药发现有潜力被讨论。在摘要,这些调查结果将提供珍贵信息更好在 anticancer 治疗学的未来发展利用 autophagy 那个会临床的要求。 | Xin LI Huai-long XU Yong-xi LIU Na AN Si ZHAO Jin-ku BAO | 2013 | Acta Pharmacologica Sinica2013，34，5： | 9 |
| 2 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 3 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 4 | Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study显示文摘Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1]. | YANG Jing Li HUANG Jun Jun CHENG Ning ZHANG De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao DING Jiao LIU Nian BAO Kai Fang DING Jie CHEN Xiao Liang ZHENG Tong Zhang BAI Ya Na | 2020 | Biomedical and Environmental Sciences2020，33，8： | 4 |
| 5 | Green Tea Polyphenols Alleviate Autophagy Inhibition Induced by High Glucose in Endothelial Cells显示文摘Bovine aortic endothelial cells(BAECs)were cultured with high glucose(33 mmol/L),4 mg/L green tea polyphenols(GTPs)or 4 mg/L GTPs co-treatment with high glucose for 24 h in the presence or absence of Bafilomycin-A1(BAF).We observed that high glucose increased the accumulation of LC3-II.Treatment with BAF did not further increase the accumulation of LC3-II.Results also showed an increased level of p62 | ZHANG Pi Wei TIAN Chong XU Fang Yi CHEN Zhuo Raynard BURNSIDE YI Wei Jie XIANG Si Yun XIE Xiao WU Nan Nan YANG Hui ZHAO Na Na YE Xiao Lei YING Chen Jiang | 2016 | Biomedical and Environmental Sciences2016，29，7： | 3 |
| 6 | The preliminary processing and analysis of LPR Channel-2B data from Chang'E-3显示文摘The Lunar Penetrating Radar(LPR)carried by Chang’E-3 has imaged the shallow subsurface of the landing site at the northern Mare Imbrium.The antenna B of the Channel-2 onboard the LPR(LPR Channel-2B)has collected more than 2000 traces of usable raw data.Because of the low resolution and noise of the raw data,only a few shallow geological structures are visible.To improve the resolution and the signal-to-noise ratio of the LPR data,we processed the LPR data including amplitude compensation,filtering,and deconvolution processes.The processing results reveal that the data processing in this study not only improves the signal-to-noise ratio of the LPR Channel-2B data but also makes the geological structures vivid.The processing results will lay the foundation for the subsequent geological interpretation and physical property inversion of lunar materials. | ZHAO Na ZHU Pei Min YANG Ke Si YUAN Yue Feng GUO Shi Li | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，12： | 2 |
| 7 | Heavy Metal Assessment among Chinese Nonferrous Metal-exposed Workers from the Jinchang Cohort Study显示文摘Environmental exposure to heavy metals has been linked to a wide range of human health hazards.We detected the levels of 15 metals in urine samples from 500 representative sub-samples in an ongoing occupational cohort study(Jinchang Cohort)to directly evaluate metal exposure levels.Fifteen metals,namely As,Ba,Be,Cd,Cs,Cr,Co,Cu,Pb,Mn,Ni,Se,Tl,U,and Zn,were detected by inductively coupled plasma quadruple mass spectrometry.The results showed that median creatinine adjustment and geometric mean urinary metal levels were higher in the heavy metal-exposed group,except Se and Zn,than other reported general or occupational populations.Further studies should address the effects of heavy metals on human health. | YANG Ai Min CHENG Zhi Yuan PU Hong Quan CHENG Ning LI Hai Yan LIU Si Min DING Jiao LI Juan Sheng HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2017 | Biomedical and Environmental Sciences2017，30，7： | 2 |
| 8 | Influence of Soy Isoflavone on Lindane Cumulant in Sprague-Dawley Rats显示文摘Female Sprague-Dawley rats weighing 60-80 g were given different dosages of soy isoflavones and/or lindane for four weeks.Soy isoflavones was added in feed and lindane was given by oral gavage.We found that soy isoflavones could reduce the level of lindane in rat’s serum and brain,but might cause the uterus hyperplasia.Lindane could inhibit the effect of soy isoflavones on uterus and | YANG Yang ZHANG Yun Bo SHENG Wei FU Zheng Hai WANG Zhe WANG Xiao GUAN Si Yuan NA Xiao Lin | 2014 | Biomedical and Environmental Sciences2014，27，8： | 2 |
| 9 | Metal Exposure and Risk of Diabetes and Prediabetes among Chinese Occupational Workers显示文摘Objective To study the association between metal exposure and risk of diabetes and prediabetes among Chinese workers exposed to metals.Methods We used data obtained from the baseline survey of the Jinchang Cohort Study of workers in Jinchang Industry,the largest nickel production company in China.A total of 42,122 workers ≥20 years of age were included in the study.A standardized,structured questionnaire was used to collect epidemiological information.Physical examinations and laboratory tests were conducted to evaluate the health status of the participants and to measure various biomarkers including blood sugar,lipids,and urinary metal concentrations.Logistic regression was used to study the association between occupational groups categorized according to the measured metal levels(office workers,low-level;mining/production workers,mid-level;and smelting/refining workers,high-level)and risk of diabetes and prediabetes.Results The overall prevalence of diabetes and prediabetes was 7.5% and 16.8%,respectively.The adjusted odds ratios for diabetes among mining/production workers and smelting/refining workers compared to office workers were 1.5(95% CI:1.3,1.7)and 3.8(95% CI:3.4,4.3),respectively.No association was observed between these occupational groups and prediabetes in this study.Conclusion Occupations associated with higher levels of metal exposure were associated with an increased risk of diabetes in this cohort.More studies are needed to confirm this observed association. | YANG Ai Min CHENG Ning PU Hong Quan LIU Si Min LI Juan Sheng BASSIG Bryan A. DAI Min LI Hai Yan HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2015 | Biomedical and Environmental Sciences2015，28，12： | 2 |
| 10 | Epinephrine increases DNA synthesis via ERK1/2s through cAMP, Ca (2+)/PKC, and PI3K/Akt signaling pathways in mouse embryonie stem cells 显示文摘 | Kim MO Na SI Lee MY | 2008 | J Cell Bioehem2008，104，46： | 1 |
| 11 | Sedimentary Age of the Baoligaomiao Formation in the Zhanlantun Area, Inner Mongolia:Constraints by Fossil Assemblage and Zircon Geochronology显示文摘The Baoligaomiao Formation is widely distributed fromthe East Wuqi to Zhanlantun area in the Xing'anMongolian orogenic belt (Tian Shugang et al., 2016; Weiet al., 2017). This formation contains abundant Angarabiological fossils which exhibit diachronismcharacteristics and are mostly incomplete. Therefore, thoseAngara fossils reported are unable to limit the exactsedimentary age of the Baoligaomiao Formation. | QIN Tao QIAN Cheng LI Linchuan JIANG Bin SUN Wei NA Fuchao SI Qiuliang MA Yongfei ZANG Yanqing | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 1 |
| 12 | Autophagy promotes intracellular degradation of type I collagen induced by transforminggrowth factor (TGF)-β1显示文摘 | Kim SI Na HJ Ding Y | 2012 | J Biol Chem2012，287，15： | 1 |
| 13 | Multilevel structured polyacrylonitrile/silica nanofibrous membranes for highperformance air filtration显示文摘 | Wang Na Si Yinsong Wang Ni | 2014 | Separation and Purification Technology2014，126，15： | 1 |
| 14 | Sulfonamide-eontaining poly- mers: a new class of pH-sensitive polymers and gels显示文摘 | Kang SI Na K Bae YH | 2001 | Macromol Symp2001，172，1： | 1 |
| 15 | Autophagy promotes intracellular degradation of type I collagen induced by transforming growth fac- tor (TGF) -131 显示文摘 | Kim SI Na HJ Ding Y | 2012 | J Biol Chem2012，287，11： | 1 |
| 16 | Autophagy promotes intracellular degradation of type Ⅰ collagen induced by transforming growth factor (TGF)-β1显示文摘 | Kim SI Na H J Ding Y | 2012 | J Biol Chem2012，287，11： | 1 |
| 17 | The a- chain of insulin is a hot-spot for CD4( + ) T cell epitopes in human type 1 diabetes 显示文摘 | Mannering SI Pang SH Williamson NA | 2009 | Clin Exp Immunol2009，156，2： | 1 |
| 18 | Attention and the identification of parafoveal words in school-age children and adults显示文摘 | Eric Siéroff Miléna Riva | 2011 | Journal of Neurolinguistics2011，，4： | 1 |
| 19 | Clinical outcome for laparoscopic cholecystectomy in extremely elderly patients显示文摘 | Lee SI Na BG Yoo YS | 2015 | Ann Surg Treat Res2015，88，3： | 1 |
| 20 | 2,3-Benzodiazepinetype AMPA receptor antagonists and their neuroprotective effects显示文摘 | Ga'bor Sze'na'si Vegh M Szabo G | 2008 | Neurochemistry International2008，52，： | 1 |
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