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| 1 | Cell surface activation of progelatinase A (proMMP-2) and cell migration显示文摘Gelatinase A (MMP-2) is considered to play a critical role in cell migration and invasion. The proteinase is secreted from the cell as an inactive zymogen. In vivo it is postulated that activation of progelationase A (proMMP-2) takes place on the cell surface mediated by membrane-type matrix metalloproteinases (MT-MMPs). Recent studies have demonstrated that proMMP-2 is recruited to the cell surface by interacting with tissue inhibitor of metalloproteinases-2 (TIMP-2) bound to MT1MMP by forming a ternary complex. bee MT1-MMP closely located to the ternary complex then activates proMMP-2 on the cell surface. MT1-MMP is found in cultured invasive cancer cells at the invadopodia. The MTMMP/TIMP-2/ MMP- 2 system t bus provides localized expression of proteolysis of the extracellular matrix required for cell migration. | NAGASE HIDEAKI(Department of Biochemistry and Molecular Biology,University of Kansas Medical Center, 3901 Rainbow Blvd,Kansas City, KS 66160. E-mail: hnagase@kumc.edu) | 1998 | Cell Research1998，8，3： | 6 |
| 2 | Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry显示文摘 | Robert Visse Hideaki Nagase | 2003 | Circulation Research: Journal of the American Heart Association2003，，8： | 4 |
| 3 | Fatal liver failure caused by reactivation of lamivudine-resistant hepatitis B virus:A case report显示文摘We present a case of fetal liver failure caused by the activation of lamivudine-resistant hepatitis B virus (HBV) nine months after lamivudine treatment. A 57-year old man visited our hospital for the treatment of decompensated chronic hepatitis B. Lamivudine was started in December 2001. Subsequently, serum HBV was negative for HBV DNA with seroconversion from HBeAg to anti-HBe and improvement of liver function. However, HBV DNA and HBeAg were again detected in September 2002. He was complicated by breakthrough hepatitis and admitted to our hospital in November for severely impaired liver function. Vidarabine treatment was started and serum HBV DNA and alanine aminotransferase (ALT) decreased transiently. However, after the start of α-interferon treatment, HBV DNA level increased and liver function deteriorated. He died 1 mo after admission. An analysis of amino acid sequences in the polymerase region revealed that rtM204I/V with rtL80I/V occurred at the time of viral breakthrough. After the start of antiviral treatment, rtL180M was detected in addition to rtM204I/V and rtL80I/V, and became predominant in the terminal stage of the disease. HBV clone with a high replication capacity may be produced by antiviral treatment leading to the worsening of liver function. Antiviral therapy for patients with breakthrough hepatitis in advanced liver disease should be carefully performed. | Yuka Suzuki Hiroshi Yotsuyanagi Chiaki Okuse Yoshihiko Nagase Hideaki Takahashi Kyoji Moriya Michihiro Suzuki Kazuhiko Koike Shiro Iino Fumio Itoh | 2007 | World Journal of Gastroenterology2007，13，6： | 4 |
| 4 | Risk factors for retinopathy associated with interferonα-2b and ribavirin combination therapy in patients with chronic hepatitis C显示文摘AIM: To elucidate the frequency and risk factors for retinopathy in patients with chronic hepatitis C who are treated by interferon-ribavirin combination therapy. METHODS: We prospectively analyzed 73 patients with histologically confirmed chronic hepatitis C, who underwent combination therapy for 24 wk. Optic fundi were examined before, and 2, 4, 12 and 24 wk after the start of combination therapy. RESULTS: Fourteen patients (19%) developed retinopathy, which was initially diagnosed by the appearance of a cotton wool spot in 12 patients. Retinal hemorrhage was observed in 5 patients. No patient complained of visual disturbance. Retinopathy disappeared in 9 patients (64%) despite the continuation of combination therapy. However, retinopathy persisted in 5 patients with retinal hemorrhage. A comparison of the clinical background between the groups with and without retinopathy showed no significant differences in age, gender, viral genotype, RNA level, white blood cell count, platelet count, prothrombin time, complications by diabetes mellitus or hypertension, or pretreatment arteriosclerotic changes in the optic fundi. However, multiple logistic regression analysis revealed that complication by hypertension was observed with a high frequency in the group with retinopathy (P = 0.004, OR=245.918, 95% CI=5.6-10786.2). CONCLUSION: Retinopathy associated with combination therapy of interferon a-2b and ribavirin tends to develop in patients with hypertension. | Chiaki Okuse Hiroshi Yotsuyanagi Yoshihiko Nagase Yuhtaro Kobayashi Kiyomi Yasuda Kazuhiko Koike Shiro Iino Michihiro Suzuki Fumio Itoh | 2006 | World Journal of Gastroenterology2006，12，23： | 4 |
| 5 | 干线运行中轮轨间的粘着系数显示文摘作者制作了一种试验滑动粘着的转向架,这种转向架是根据运行中不断测定粘着系数的新观念而设计的,用于测定在干线运行中的粘着状态。 | Kazuhiko Nagase 周贤全 | 1990 | 国外铁道车辆1990，27，5： | 3 |
| 6 | Laparoscopic and endoscopic cooperative surgery for duodenal neuroendocrine tumor (NET) G1: Report of a case显示文摘 | Takaaki Tsushimi Hirohito Mori Takasuke Harada Takashi Nagase Yoshitaka Iked Hiromo Ohnishi | 2014 | International Journal of Surgery Case Reports2014，，12： | 3 |
| 7 | Whole-breast radiotherapy with shorter fractionation schedules following breast-conserving surgery: short-term morbidity and preliminary outcomes显示文摘 | Osamu Fujii Jyunichi Hiratsuka Naomi Nagase Ryuji Tokiya Eisaku Yoden Hiroshi Sonoo Nobutaka Murashima Shigemichi Iha Yoshinari Imajyo | 2008 | Breast Cancer2008，，1： | 2 |
| 8 | Effectiveness of therapeutic barium enema for diverticular hemorrhage显示文摘AIM:To evaluate the effectiveness of barium impaction therapy for patients with colonic diverticular bleeding.METHODS:We reviewed the clinical charts of patients in whom therapeutic barium enema was performed for the control of diverticular bleeding between August2010 and March 2012 at Yokohama Rosai Hospital.Twenty patients were included in the review,consisting of 14 men and 6 women.The median age of the patients was 73.5 years.The duration of the followup period ranged from 1 to 19 mo(median:9.8 mo).Among the 20 patients were 11 patients who required the procedure for re-bleeding during hospitalization,6patients who required it for re-bleeding that developed after the patient left the hospital,and 3 patients who required the procedure for the prevention of rebleeding.Barium(concentration:150 w%/v%)was administered per the rectum,and the leading edge of the contrast medium was followed up to the cecum by fluoroscopy.After confirmation that the ascending colon and cecum were filled with barium,the enema tube was withdrawn,and the patient’s position was changed every 20 min for 3 h.RESULTS:Twelve patients remained free of rebleeding during the follow-up period(range:1-19mo)after the therapeutic barium enema,including 9men and 3 women with a median age of 72.0 years.Re-bleeding occurred in 8 patients including 5 men and 3 women with a median age of 68.5 years:4developed early re-bleeding,defined as re-bleeding that occurs within one week after the procedure,and the remaining 4 developed late re-bleeding.The DFI(disease-free interval)decreased 0.4 for 12 mo.Only one patient developed a complication from therapeutic barium enema(colonic perforation).CONCLUSION:Therapeutic barium enema is effective for the control of diverticular hemorrhage in cases where the active bleeding site cannot be identified by colonoscopy. | Mizue Matsuura Masahiko Inamori Atsushi Nakajima Yasuhiko Komiya Yumi Inoh Keigo Kawasima Mai Naitoh Yuji Fujita Akiko Eduka Noriyoshi Kanazawa Shiori Uchiyama Rie Tani Kennichi Kawana Setsuya Ohtani Hajime Nagase | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 9 | The relationship between percentage of organic matter in substrate and plant growth in extensive green roofs显示文摘 | Ayako Nagase Nigel Dunnett | 2011 | Landscape and Urban Planning2011，，2： | 2 |
| 10 | Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA显示文摘 | Takeru Hayashi Miki Senda Hiroko Morohashi Hideaki Higashi Masafumi Horio Yui Kashiba Lisa Nagase Daisuke Sasaya Tomohiro Shimizu Nagarajan Venugopalan Hiroyuki Kumeta Nobuo N. Noda Fuyuhiko Inagaki Toshiya Senda Masanori Hatakeyama | 2012 | Cell Host & Microbe2012，，1： | 2 |
| 11 | Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: A 3‐year prospective randomized open trial显示文摘 | Koji Yoshida Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Yoko Yokoyama Masaki Iimuro Naohisa Takeda Kyoichi Kato Risa Kikuyama Kazuko Nagase Kazutoshi Hori Shiro Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Inflamm Bowel Dis2011，，9： | 2 |
| 12 | Diabetes enhances lectin-like oxidized LDL receptor-1(LOX-1)expression in the vascular endothelium:possible role of LOX-1 ligand and AGE显示文摘 | Chen M Nagase M Fujita T | 2001 | Biochem Biophys Res Commun2001，287，4： | 2 |
| 13 | Malignant Transformation Arising From Mature Cystic Teratoma of the Ovary: A Retrospective Study of 20 Cases显示文摘 | Michiko Sakuma Takeo Otsuki Kosuke Yoshinaga Hiroki Utsunomiya Satoru Nagase Tadao Takano Hitoshi Niikura Kiyoshi Ito Keiko Otomo Toru Tase Yoh Watanabe Nobuo Yaegashi | 2010 | International Journal of Gynecological Cancer2010，，5： | 2 |
| 14 | 左心房结构和功能改变可早期预测无症状高血压患者左心室功能不全显示文摘该研究旨在探索无症状高血压患者左心房结构和功能改变与左心室功能不全之间的关系。入选左心室射血分数(1eft ventricular ejection fraction,LVEF)≥60%的无症状高血压患者126例。应用常规脉冲组织多普勒及二维斑点追踪超声心动图(two-dimensional speckle—tracking echocardiography,2DSTE)检测和分析左心房结构与功能改变的独立影响因素。 | Miyoshi H Oishi Y Mizuguchi Y Iuchi A Nagase N Ara N Oki T 刘莉 叶鹏 | 2013 | 中华高血压杂志2013，21，5： | 2 |
| 15 | Tissue inhibitors of metalloproteinases : evolution, structure and function 显示文摘 | Keith Brew Deendayal Dinakarpandian Hideaki Nagase | 2000 | Biochimica et B iophysica Acta2000，1477，： | 1 |
| 16 | Matrix metalloproteinase and tissue inhibitors of metalloproteinase: structure, function, and biochemistry 显示文摘 | Visse R Nagase H | 2003 | Circ Res2003，92，8： | 1 |
| 17 | Matrix metalloproteinases显示文摘 | Nagase H Woessner JF | 1999 | J Biol Chem1999，274，21： | 1 |
| 18 | Regulation of matrix metalloproteinases (MMP 2, 3, -9, and 13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption显示文摘 | Kusano K Miyaura C Inada M Tamura T ho A Nagase H | 1998 | Endocrinology1998，139，： | 1 |
| 19 | Progress in matrix metalloproteinase research显示文摘 | Murphy G Nagase H | 2008 | Mol Aspects Med2008，29，5： | 1 |
| 20 | Fabrication technique for Si single-electron transistor operating at room temperature 显示文摘 | TAKAHASHI Y NAGASE M NAMATSU H | 1995 | Electron Lett1995，31，2： | 1 |
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