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| 1 | Role of adhesion molecules and dendritic cells in rat hepatic/renal ischemia-reperfusion injury and anti-adhesive intervention with anti-P-selectin lectin-EGF domain monoclonal antibody显示文摘AIM: To investigate the role of P-selectin, intercellular adhesion molecule-1 (ICAM-1) and dendritic cells (DCs)in liver/kidney of rats with hepatic/renal ischemiareperfusion injury and the preventive effect of anti-Pselectin lectin-EGF domain monoclonal antibody (anti-PsLEGFmAb) on the injury.METHODS: Rat models of hepatic and renal ischemiareperfusion were established. The rats were then divided into two groups, one group treated with anti-PsL-EGFmAb(n = 20) and control treated with saline (n = 20). Both groups were subdivided into four groups according to reperfusion time (1, 3, 6 and 24 h). The sham-operated group (n = 5) served as a control group. DCs were observed by the microscopic image method, while P-selectin and ICAM-1 were analyzed by immunohistochemistry.RESULTS: P-selectin increased significantly in hepatic sinusoidal endothelial cells and renal tubular epithelial cells 1 h after ischemia-reperfusion, and the expression of ICAM-1 was up-regulated in hepatic sinusoid and renal vessels after 6 h. CD1a+CD80+DCs gradually increased in hepatic sinusoidal endothelium and renal tubules and interstitium 1 h after ischemia-reperfusion, and there was the most number of DCs in 24-h group. The localization of DCs was associated with rat hepatic/renal function.These changes became less significant in rats treated with anti-PsL-EGFmAb.CONCLUSION: DCs play an important role in immune pathogenesis of hepatic/renal ischemia-reperfusion injury.Anti-PsL-EGFmAb may regulate and inhibit local DC immigration and accumulation in liver/kidney. | TongZhou Gui-ZhiSun Ming-JunZhang Jin-LianChen Dong-QingZhang Qing-ShenHu Yu-YingChen NanChen | 2005 | World Journal of Gastroenterology2005，11，7： | 16 |
| 2 | Cardiovascular risk estimation and eligibility for statins in primary prevention comparing different strategies显示文摘 | Nanchen D Chiolero A Cornuz J | 2009 | Am J Cardiol2009，103，8： | 1 |
| 3 | Resting heartrate and the risk of heart failure in healthy adults: theRotterdam Study显示文摘 | Nanchen D* Leening MJ Locatelli I | 2013 | Circ Heart Fail2013，6，3： | 1 |
| 4 | Subclinical thyroid dysfunction and the risk of heart failure in older people at high cardiovascular risk 显示文摘 | Nanchen D Gussekloo J Westendorp R G | 2012 | J Clin Endocrinol Metab2012，，： | 1 |
| 5 | Subclinical thyroid dys function and the risk of heart failure in older persons at high cardiovas- cular risk显示文摘 | Nanchen D Gussekloo J Westendorp R G | 2012 | J Clin Endocrinol Metab2012，97，3： | 1 |
| 6 | PROSPER Group: Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk 显示文摘 | Nanchen D Gussekloo J Westendorp RG | 2012 | J Clin Endoerinol Metab2012，97，3： | 1 |
| 7 | Improvement procedures for the undirected rural postman problem显示文摘 | Hertz A Laporte G Nanchen -Hugo P | 1999 | INFORMS Journal on Computing1999，11，1： | 1 |
| 8 | Expected impact of applying new 2013 AHA/ACC cholesterol guidelines criteria on the recommended lipid target achievement after acute coronary syndromes显示文摘 | Gencer B Auer 1L Nanchen D | 2014 | Atheroselerosis2014，239，1： | 1 |
| 9 | New sel&curable, aqueous-based polyurethane system by an isophorone diisocyanate/uretedione aziridinyl derivative process 显示文摘 | Jian Zeilai Hao Janling Jen Tautyeh Kan Nanchen | 2004 | Journal of Applied Polymer Science2004，94，3： | 1 |
| 10 | Single component self-curable aqueous-based PU system with new aziridinyl curing agent 显示文摘 | Jian Zeilai Hao Janling Jen Tautyeh Kan Nanchen | 2004 | Journal of Applied Polymer Science2004，91，3： | 1 |
| 11 | A cross self-curing system for an aqueous-based PU hybrid显示文摘 | Jian Zeilai Pao Janchen Jen Tautyeh Kan Nanchen | 2005 | Journal of Applied Polymer Science2005，97，2： | 1 |
| 12 | Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk 显示文摘 | Nanchen D Gusseldoo J Westendorp R G J | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，97，3： | 1 |
| 13 | Compatible and crystallization properties of poly(lactic acid)/poly(butylene adipate‐co‐terephthalate) blends显示文摘 | Jen‐TautYeh Chi‐HuiTsou Chi‐YuanHuang Kan‐NanChen Chin‐SanWu Wan‐LanChai | 2009 | J Appl Polym Sci2009，，2： | 1 |
| 14 | Alcohol drinking, the metabolic syndrome and diabetes in a population with high mean alcohol consumption显示文摘 | CLERC O NANCHEN D CORNUZ J | 2010 | Diabet Med2010，27，11： | 1 |
| 15 | The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase显示文摘 | NanChen OliverRinner DominikaCzernik Katarzyna JNytko DanZheng Daniel PStiehl NicolaZamboni MatthiasGstaiger ChristianFrei | 2011 | Cell Research2011，21，6： | 1 |
| 16 | Alcohol drinking, the metabolic syndrome and diabetes in a population with high mean alcohol consumption显示文摘 | Clerc Nanchen | 2010 | Diabet Med2010，27，11： | 1 |
| 17 | Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk显示文摘 | Nanchen D Gussekloo J Westendorp RG | | 0，，： | 1 |
| 18 | Improvement procedures for the undirected rural postman problem显示文摘 | Hertz A Laporte G Nanchen H P | 1999 | Informs Journal of Computing1999，11，1： | 1 |
| 19 | Subclinical thy- roid dysfunction and the risk of heart failure in older persons at high cardiovascular risk 显示文摘 | Nanchen D Gussekloo J Westendorp RG | 2012 | J Clin Endocrinol Metab2012，97，3： | 1 |
| 20 | Oxidation of explosives by Fenton and photo-Fenton processes显示文摘 | Ming Jerliou Ming Chunlu Jong Nanchen | 2003 | Water Research2003，37，： | 1 |
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