|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer显示文摘AIM: To investigate the expression of PTEN/MMAC1/TEP1 and vascular endothelial growth factor (VEGF), their roles in biologic behavior and angiogenesis and their association in gastric cancer.METHODS: Immunohistochemical staining was used to evaluate the expression of PTEN, VEGF and microvascular density (MVD) on paraffin-embedded sections in 70 patients with primary gastric cancer and 24 patients with chronic superficial gastritis (CSG). Expression of PTEN, VEGF and MVD were compared with clinicopathological features of gastric cancer. The relationship between expression of PTEN, VEGF and MVD as well as the relationship between PTEN and VEGF expression in caner cells were investigated. RESULTS: PTEN expression significantly decreased (t= 3.98, P<0.01) whereas both VEGF expression and MVD significant increased (t = 4.29 and 4.41, respectively, both P<0.01) in gastric cancer group compared with CSG group. PTEN expression was significantly down-regulated (t=1.95, P<0.05) whereas VEGF expression (t = 2.37, P<0.05) and MVD (t= 3.28, P<0.01) was significantly up-regulated in advanced gastric cancer compared with early-stage gastric cancer. PTEN expression in gastric cancer showed a negative association with lymph node metastasis (t= 3.91, P<0.01), invasion depth (t= 1.95, P<0.05) and age (t= 4.69, P<0.01). MVD in PTEN-negative gastric cancer was significantly higher than that in PTEN-positive gastric cancer (t=3.69, P<0.01), and there was a negative correlation betweenPTEN expression and MVD (γ=-0.363, P<0.05). VEGF expression was positively associated with invasion depth (especially with serosa invasion, t = 4.69, P<0.01), lymph node metastasis (t= 2.31, P<0.05) and TNM stage (t= 3.04, P<0.01). MVD in VEGF-positive gaslyic cancer was significantly higher than that in VEGF-negative gastric cancer (t=4.62, P<0.01), and there was a positive correlation between VEGF expression of and MVD (y = 0.512, P<0.05). VEGF expression in PTEN-negative gaslyic cancer was significantly stronger than that in PTEN-positive gastric cancer (t=2.61, P<0.05), and there was a significantly negative correlation between the expression of VEGF and PTEN (γ=-0.403, P<0.05).CONCLUSION: Our results imply that inactivation of PTEN gene and over-expression of VEGF contribute to the neovascularization and progression of gastric cancer. PTEN-related angiogenesis might be attributed to its up-regulation of VEGF expression. PTEN and VEGF could be used as the markers reflecting the biologic behaviors of tumor and viable targets in therapeutic approaches to inhibit angiogenesis of gastric cancers. | Ye-JiangZhou Yu-XiaXiong Xiao-TingWu DeShi WeiFan TongZhou Yue-ChunLi XiongHuang | 2004 | World Journal of Gastroenterology2004，10，21： | 31 |
| 2 | Role of adhesion molecules and dendritic cells in rat hepatic/renal ischemia-reperfusion injury and anti-adhesive intervention with anti-P-selectin lectin-EGF domain monoclonal antibody显示文摘AIM: To investigate the role of P-selectin, intercellular adhesion molecule-1 (ICAM-1) and dendritic cells (DCs)in liver/kidney of rats with hepatic/renal ischemiareperfusion injury and the preventive effect of anti-Pselectin lectin-EGF domain monoclonal antibody (anti-PsLEGFmAb) on the injury.METHODS: Rat models of hepatic and renal ischemiareperfusion were established. The rats were then divided into two groups, one group treated with anti-PsL-EGFmAb(n = 20) and control treated with saline (n = 20). Both groups were subdivided into four groups according to reperfusion time (1, 3, 6 and 24 h). The sham-operated group (n = 5) served as a control group. DCs were observed by the microscopic image method, while P-selectin and ICAM-1 were analyzed by immunohistochemistry.RESULTS: P-selectin increased significantly in hepatic sinusoidal endothelial cells and renal tubular epithelial cells 1 h after ischemia-reperfusion, and the expression of ICAM-1 was up-regulated in hepatic sinusoid and renal vessels after 6 h. CD1a+CD80+DCs gradually increased in hepatic sinusoidal endothelium and renal tubules and interstitium 1 h after ischemia-reperfusion, and there was the most number of DCs in 24-h group. The localization of DCs was associated with rat hepatic/renal function.These changes became less significant in rats treated with anti-PsL-EGFmAb.CONCLUSION: DCs play an important role in immune pathogenesis of hepatic/renal ischemia-reperfusion injury.Anti-PsL-EGFmAb may regulate and inhibit local DC immigration and accumulation in liver/kidney. | TongZhou Gui-ZhiSun Ming-JunZhang Jin-LianChen Dong-QingZhang Qing-ShenHu Yu-YingChen NanChen | 2005 | World Journal of Gastroenterology2005，11，7： | 16 |
| 3 | Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats显示文摘AIM: To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats. METHODS: Hepatic/renal funclJon, histopathotogical changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models. RESULTS: Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group. CONCLUSION: P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion iniury throuclh inhibition of P-selectin. | Jin-LianChen TongZhou Wei-XiongChen Jin-ShuiZhu Ni-WeiChen Ming-JunZhang Yun-LinWu | 2003 | World Journal of Gastroenterology2003，9，7： | 14 |
| 4 | Effect of P-selectin monoclonal antibody on metastasis of gastric cancer and immune function显示文摘AIM: To investigate the effect of cell adhesion molecule Pselectin monoclonal antibody (Mab) on metastasis and immune function of mice orthototopically implanted with human gastric cancer tissue.METHODS: SCID mice were implanted orthotopically with SGC-7901 human gastric carcinoma tissue. Starting from day 3 after operation, animals were given intravenously PBS or P-selectin Mab (100 μg/injection) (for both normal mice and tumor-implanted mice with tumors), twice weekly for 3weeks. Two animals in each group were sacrificed randomly at the 1st, 2nd, 4th week and 6th week. While T cell and B cell transformation indices were determined with the 3H TdR infiltration method, the NK cell activity was detected by the LDH release method.RESULTS: The metastatic rate in the P-selectin Mab treated group was lower than that in the PBS treated group (with tumors). The NK activity of normal mice increased over time.The immune functions (T, B cell function, NK activity) of the tumor group in the 6th week were significantly lower than those in the 4th week, but the change was attenuated by Pselectin Mab.CONCLUSION: P-selectin Mab could suppress the metastasis of gastric cancer with no adverse effect on host immune function. | Jin-Lian Wei-xiongChen Jin-ShuiZhu Ni-WeiChen TongZhou Yun-LinWu MingYao Dong-QingZhang | 2003 | World Journal of Gastroenterology2003，9，7： | 12 |
| 5 | Ni_(2)P/NiMoP heterostructure as a bifunctional electrocatalyst for energy-saving hydrogen production显示文摘Electrochemical water splitting is a sustainable and feasible strategy for hydrogen production but is hampered by the sluggish anodic oxygen evolution reaction(OER).Herein,an effective approach is introduced to significantly decrease the cell voltage by replacing the anodic OER with a urea oxidation reaction(UOR).A Ni_(2)P/NiMoP nanosheet catalyst with a hierarchical architecture is uniformly grown on a nickel foam(NF)substrate through a simple hydrothermal and phosphorization method.The Ni_(2)P/NiMoP achieves impressive HER activity,with a low overpotential of only 22 mV at 10 mA cm^(-2)and a low Tafel slope of 34.5 mV dec^(−1).In addition,the oxidation voltage is significantly reduced from 1.49 V to 1.33 V after the introduction of 0.33 M urea.Notably,a two-electrode electrolyzer employing Ni_(2)P/NiMoP as a bifunctional catalyst exhibits a current density of 10 mA cm^(-2)at a cell voltage of 1.35 V and excellent long-term durability after 80 h. | Tongzhou Wang Xuejie Cao Lifang Jiao | 2021 | eScience2021，1，1： | 10 |
| 6 | Historical retrospect and future prospect of research on effective teaching in China——Knowledge mapping analysis based on the research over the past three decades (1986-2016)显示文摘This paper takes China National Knowledge Infrastructure (CNKI) as its literature data sources, and uses Bicomb and SPSS software to draw knowledge mapping for the hot spots of 290 papers about effective teaching in China from 1986 to 2016, so as to visually show the hot issues and development trend of effective teaching over the past three decades in China. The research shows that hot issues in effective teaching research over the past 30 years mainly fall into the following three categories: First, effective teaching studies on classroom teaching activities (from the perspective of teachers);Second, effective teaching studies under the background of new curriculum reform (perspective of curriculum reform);Third, effective teaching studies on students' self-learning (from the perspective of students). Effective teaching research in China in the future should grasp the following trends: Firstly, expansion of concept from static definition to dynamic understanding. Secondly, change of research perspective from focusing on teachers' teaching behavior to students' learning process and learning situation. Thirdly, deepening of research content from macro expound based on new curriculum reform to medium and micro research that combines core competence development of the students, the discipline core quality formation, and the implementation of specific curriculum standards. Fourthly, concordance of research methods from theoretical speculation and qualitative analysis to comprehensive study blending multiple research methods. | Chen Xiaoduan Sun Yuan He Tongzhou | 2018 | Advances in Higher Education2018，2，2： | 2 |
| 7 | Power Fluctuation Damping of Thermostatically Controlled Loads Based on State Estimation显示文摘As a kind of important demand side resource,the thermostatically controlled loads(TCLs)play an important role in the peak load shifting and load balancing programs.This paper establishes a state-queuing(SQ)model for the large-scale TCLs,and estimates the system states based on the Kalman-filtering.Based on state estimation,the control strategy,whose parameters are optimized by the genetic algorithm(GA),is designed to damp the power fluctuation of the TCLs.Finally,the effectiveness of the proposed method is verified. | Yuqing Bao Xueting Zhou Tongzhou Ji Jinlong Zhang Xiaobo Tang Yang Wu | 2020 | CSEE Journal of Power and Energy Systems2020，6，4： | 2 |
| 8 | PEM water electrolysis for hydrogen production:fundamentals,advances,and prospects显示文摘Hydrogen,as a clean energy carrier,is of great potential to be an alternative fuel in the future.Proton exchange membrane(PEM)water electrolysis is hailed as the most desired technology for high purity hydrogen production and self-consistent with volatility of renewable energies,has ignited much attention in the past decades based on the high current density,greater energy efficiency,small mass-volume characteristic,easy handling and maintenance.To date,substantial efforts have been devoted to the development of advanced electrocatalysts to improve electrolytic efficiency and reduce the cost of PEM electrolyser.In this review,we firstly compare the alkaline water electrolysis(AWE),solid oxide electrolysis(SOE),and PEM water electrolysis and highlight the advantages of PEM water electrolysis.Furthermore,we summarize the recent progress in PEM water electrolysis including hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)electrocatalysts in the acidic electrolyte.We also introduce other PEM cell components(including membrane electrode assembly,current collector,and bipolar plate).Finally,the current challenges and an outlook for the future development of PEM water electrolysis technology for application in future hydrogen production are provided. | Tongzhou Wang Xuejie Cao Lifang Jiao | 2022 | Carbon Neutrality2022，1，1： | 2 |
| 9 | Crystalline-amorphous interfaces of NiO-CrO_(x)electrocatalysts for boosting the urea oxidation reaction显示文摘The overall energy efficiency of electrochemical systems is severely hindered by the traditional anodic oxygen evolution reaction(OER).Utilizing urea oxidation reaction(UOR)with lower thermodynamic potential to replace OER provides a promising strategy to enhance the energy efficiency.Amorphous and heterojunctions electrocatalysts have been aroused extensive studies owing to their unique physicochemical properties and outperformed activity.Herein,we report a simple method to construct a novel crystalline-amorphous NiO-CrO_(x)heterojunction grown on Ni foam for UOR electrocatalyst.The NiO-CrO_(x)electrocatalyst displays excellent UOR performance with an ultralow working potential of 1.32 V at 10 mA·cm^(−2)and ultra-long stability about 5 days even at 100 mA·cm^(−2).In-situ Raman analysis and temperature-programmed desorption(TPD)measurement verify that the presence of the amorphous CrO_(x)phase can boost the reconstruction from NiO to active NiOOH species and enhance adsorption ability of urea molecule.Besides,the unique crystalline-amorphous interfaces are also benefit to improving the UOR performance. | Xuejie Cao Tongzhou Wang Hongye Qin Guangliang Lin Lihua Zhao Lifang Jiao | 2023 | Nano Research2023，16，3： | 1 |
| 10 | Effects of humic acid on arsenic(V) removal by zero-valent iron from groundwater with special references to corrosion products analyses显示文摘 | Pinhua Rao Mark S.H. Mak Tongzhou Liu Keith C.K. Lai Irene M.C. Lo | 2009 | Chemosphere2009，，2： | 1 |
| 11 | Environ Sci Technol显示文摘 | Tongzhou Liu Daniel C W Tsang Irene M C L O | 2008 | 42(6):2092-20982008，42，6： | 1 |
| 12 | Status quo of ewaste management in mainland China显示文摘 | LI Jinhui TIAN Baoguo LIU Tongzhou | 2006 | Mater Cycles Waste Management2006，，8： | 1 |
| 13 | Status quo of E-waste management in mainland China显示文摘 | LI Jinhui TIAN Baoguo LIU Tongzhou | 2006 | Journal of Material Cycles and Waste Management2006，8，1： | 1 |
| 14 | Enhanced synergistic denitrification and chemical precipitation in a modified BAF process by using Fe2+ 显示文摘 | Wang Hongjie Dong Weiyi Li Ting Liu Tongzhou | 2014 | Bioresource Technology2014，151，： | 1 |
| 15 | Effects on inorganic nitrogen compounds release of contaminated sediment treatment with in situ calcium nitrate injection显示文摘 | Liu Tongzhou Yuan Jiajia Dong Wenyi | 2015 | Environ Sci Pollut Res2015，22，： | 1 |
| 16 | Influences of humic acid, bicarbonate and calcium on Cr (Ⅵ) reductive removal by zero- valent iron显示文摘 | LIU Tongzhou RAO Pinhua LO I M C | 2009 | Science of the Total Environment2009，407，10： | 1 |
| 17 | Removal of co-present chromate and arsenate by zero-valent iron in groundwater with humic acid and bicarbonate 显示文摘 | Liu Tongzhou Rao Pinhua Mak M S H | 2009 | Water Research2009，43，9： | 1 |
| 18 | Chromium ( VI ) reduction kinetics by zero-valent iron in moderately hard water with humic acid :iron dis- solution and humic acid adsorption 显示文摘 | Liu Tongzhou Tsang D Lo I | 2008 | Environmental Science and Technology2008，42，6： | 1 |
| 19 | Automatic visual/IR image regis- tration 显示文摘 | HUI Henryli YI Tongzhou | 1996 | Society of Photo - optical Instrumentation Engi- neers1996，35，2： | 1 |
| 20 | Influences of humic acid,bi- carbonate and calcium on Cr( VI ) reductive removal by zero-valent iron 显示文摘 | Liu Tongzhou Rao Pinhua Lo I M C | 2009 | Science of the Total Environment2009，407，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员