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| 1 | Regulation of sympathatic activity inchildrenwith vanous congenital heart diseaess 显示文摘 | Omar G Omar G | 1995 | Pediatr Res1995,38,1: | 1 |
| 2 | Impact of stepping stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa:cluster ran- domised controlled trial 显示文摘 | Jewkes R Nduna M Levin J | 2008 | British Medical Journal2008,337,: | 1 |
| 3 | Intimate partner violence, relationship power inequity, and incidence of HIV infection in young women in South Africa: a cohort study 显示文摘 | Jewkes RK Dunkle K Nduna M | 2010 | Lancet2010,376,9734: | 1 |
| 4 | A study of the role of GATA2 gene polymorphism in coronary artery disease risk traits显示文摘 | Nzioka P. Muiya Salma Wakil Mohammed Al-Najai Asma I. Tahir Batoul Baz Editha Andres Olyan Al-Boudari Nada Al-Tassan Maie Al-Shahid Brian F. Meyer Nduna Dzimiri | 2014 | Gene2014,,2: | 1 |
| 5 | Experience and lessons from health impact assessment guiding prevention and control of HIV/AIDS in a copper mine project,northwestern Zambia显示文摘Background:To avoid or mitigate potential project-related adverse health effects,the Trident copper project in Kalumbila,northwestern Zambia,commissioned a health impact assessment.HIV was identified a priority health issue based on the local vulnerability to HIV transmission and experience from other mining projects in Africa.Hence,an HIV/AIDS management plan was developed,including community and workplace interventions,with HIV testing and counselling(HTC)being one of the key components.We present trends in HTC data over a 4-year period.Methods:In 13 communities affected by the Trident project,HTC was implemented from 2012 onwards,using rapid diagnostic tests,accompanied by pre-and post-test counselling through trained personnel.In addition,HTC was initiated in the project workforce in 2013,coinciding with the launch of the mine development.HTC uptake and HIV positivity rates were assessed in the study population and linked to demographic factors using regression analysis.Results:In total,11,638 community members and 5564 workers have taken up HTC with an increase over time.The HIV positivity rate in the community was 3.0%in 2012 and 3.4%in 2015,while positivity rate in the workforce was 5.2%in 2013 and 4.3%in 2015.Females showed a significantly higher odds of having a positive test result than males(odds ratio(OR)=1.96,95%confidence interval(CI):1.55-2.50 among women in the community and OR=2.90,95%CI:1.74-4.84 among women in the workforce).HTC users in the 35-49 years age group were most affected by HIV,with an average positivity rate of 6.6%in the community sample and 7.9%in the workforce sample.These study groups had 4.50 and 4.95 higher odds of being positive,respectively,compared to their younger counterparts(15-24 years).Conclusions:While HTC uptake increased five-fold in the community and almost three-fold in the workplace,the HIV positivity rates were insignificantly higher in 2015 compared to 2012.Our data can be used alongside other surveillance data to track HIV transmission in this specific context.Guided by the health impact assessment,the HIV prevention and control programme was readily adapted to the current setting through the identification of socioeconomic and environmental determinants of health. | Astrid M.Knoblauch Mark J.Divall Milka Owuor Kennedy Nduna Harrison Ng’uni Gertrude Musunka Anna Pascall Jürg Utzinger Mirko S.Winkler | 2017 | Infectious Diseases of Poverty2017,6,1: | 1 |
| 6 | Masculinities and condom use patterns among young rural South Africa men: a cross--sec- tional baseline survey显示文摘 | Shai NJ Jewkes R Nduna M | 2012 | BMC Public Health2012,12,: | 1 |
| 7 | Characterization of lymphocyte 132-adrenoeeptor signaling in patients with ventrieular volume overload disease显示文摘 | Nduna D Chona B Azadali M | 2002 | Clin Exp Pharmacol2002,29,: | 1 |
| 8 | Integrated Genomic and Network-Based Analyses of Complex Diseases and Human Disease Network显示文摘A disease phenotype generally reflects various pathobiological processes that interact in a complex network. The highly interconnected nature of the human protein interaction network(interactome) indicates that, at the molecular level, it is difficult to consider diseases as being independent of one another. Recently, genome-wide molecular measurements, data mining and bioinformatics approaches have provided the means to explore human diseases from a molecular basis. The exploration of diseases and a system of disease relationships based on the integration of genome-wide molecular data with the human interactome could offer a powerful perspective for understanding the molecular architecture of diseases. Recently, subnetwork markers have proven to be more robust and reliable than individual biomarker genes selected based on gene expression profiles alone, and achieve higher accuracy in disease classification. We have applied one of these methodologies to idiopathic dilated cardiomyopathy(IDCM) data that we have generated using a microarray and identified significant subnetworks associated with the disease. In this paper, we review the recent endeavours in this direction, and summarize the existing methodologies and computational tools for network-based analysis of complex diseases and molecular relationships among apparently different disorders and human disease network. We also discuss the future research trends and topics of this promising field. | Olfat Al-Harazi Sadiq Al Insaif Monirah A.Al-Ajlan Namik Kaya Nduna Dzimiri Dilek Colak | 2016 | Journal of Genetics and Genomics2016,43,6: | 0 |