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| 1 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 2 | Modified Koyanagi's procedure for proximal hypospadias: our experience 显示文摘 | NERLI R SANTHOSHI P GUNTAKA A | 2010 | Int J Urol2010，17，3： | 1 |
| 3 | Prepubertal testiculartumors: our 10 years experience显示文摘 | Nerli RB A jay G Shivangouda P | 2010 | Indian J Cancer2010，47，3： | 1 |
| 4 | Flexible ureteroscopy for upper ureteral calculi in children显示文摘 | Nerli RB Patil SM Guntaka AK | | 0，，04： | 1 |
| 5 | Flexible ureteros- copy for upper ureteral calculi in children显示文摘 | Nerli RB Patil SM Guntaka AK | 2011 | J Endourol2011，25，4： | 1 |
| 6 | Laparoscopic adrenalectomy for large pheochromocytoma显示文摘 | Indupur RR Nerli RB Reddy MN | 2007 | BJU Int2007，100，5： | 1 |
| 7 | Flexible ureteroscopy for upper ureteral calculi in children显示文摘 | Nerli RB Patil SM Guntaka AK | 2011 | J Endourol2011，25，4： | 1 |
| 8 | Transvesicoscopic repair of vesicovaginal fistula显示文摘 | Nerli R Reddy M | 2010 | Diagn Ther Endosc2010，1155，1： | 1 |
| 9 | Cystoscopy- assisted laparoscopic partial cystectomy显示文摘 | Nerli R B Reddy M Koura A C | 2008 | J Endou- rol2008，22，1： | 1 |
| 10 | Flexible ureteroscopy for upper ureteral calculi in children显示文摘 | Nerli RB Patil SM Guntaka AK | 2011 | J Endourol2011，25，4： | 1 |
| 11 | Extraction of Trypsin from BovinePancreas by Applying Polyethleneglycol/ Sodium Citrate Aqueous Two-Phase Systems显示文摘 | Tubio G PicdG A Nerli B B | 2009 | Journal of Chromatography B2009，877，3： | 1 |
| 12 | The effects of alfentanil or remifentanil pretreatment on propofol injection pain显示文摘 | Iyilikci L Balkan B K Gkel E Günerli A Ellidokuz H | 2004 | J Clin Anesth2004，16，： | 1 |
| 13 | Protein-flexible chain polymer interactions to explain protein partition in aqueous two-phase systems and the protein–polyelectrolyte complex formation显示文摘 | Valeria Boeris Beatriz Farruggia Bibiana Nerli Diana Romanini Guillermo Picó | 2007 | International Journal of Biological Macromolecules2007，，3： | 1 |
| 14 | Flexible Ureteroseopy for Upper Ureteral Calculi in Children 显示文摘 | Nerli Rajendra B Patil Shivagouda M Guntaka Ajay Kumar | 2011 | Journal of Endourology2011，25，4： | 1 |
| 15 | Prepubertal testicular tumors:our 10 years experience显示文摘 | Nerli RB Ajay G Shivangouda P | 2010 | Indian J Cancer2010，47，3： | 1 |
| 16 | Percutaneous nephrolithotomy in patients on chronic anticoagulant/antiplatelet therapy显示文摘 | Nerli RB Reddy MN Devaraju S | 2012 | Chonnam Med J2012，48，2： | 1 |
| 17 | Partitioning features of bovine trypsin and - chymotrypsin in polyethyleneglycol - sodium citrate aqueous two - phase systems 显示文摘 | Tub' io G Nerli B Pic' o G | 2007 | Journal of Chromatography B2007，852，12： | 1 |
| 18 | Flexible ureteroscopy for upper ureteral calculi in children显示文摘 | Nerli RB Patil SM Guntaka AK | 2011 | J Endourol2011，25，12： | 1 |
| 19 | Partitioning features of bovine trypsin and-chymotrypsin in polyethyleneglycol-sodium citrate aqueoustwo-phase systems 显示文摘 | Tub io G Nerli B Pic o G | 2007 | Journal of Chromatography B2007，852，12： | 1 |
| 20 | Protein-flexible chain polymer interactions to explain protein partition in aqueous two-phase systems and the protein-polyelectrolyte complex formation显示文摘 | Boeris V Farruggia B Nerli B | 2007 | International Journal of Biological Macromolecules2007，41，： | 1 |
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